Dysfunction in emotion processing underlies functional (psychogenic) dystonia
Open accessAbstract
Objective: We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common functional movement disorders. Methods: Motor and emotion circuits were examined in 12 participants with functional dystonia, 12 with primary organic dystonia, and 25 healthy controls using functional magnetic resonance imaging at 4T and a finger‐tapping task (motor task), a basic emotion‐recognition task (emotional faces task), and an intense‐emotion stimuli task. Results: There were no differences in motor task activation between groups. In the faces task, when compared with the other groups, functional dystonia patients showed areas of decreased activation in the right middle temporal gyrus and bilateral precuneus and increased activation in the right inferior frontal gyrus, bilateral occipital cortex and fusiform gyrus, and bilateral cerebellum. In the intense‐emotion task, when compared with the other groups, functional dystonia patients showed decreased activation in the left insular and left motor cortices (compared to organic dystonia, they showed an additional decrease in activation in the right opercular cortex and right motor cortex) and increased activation in the left fusiform gyrus. Conclusions: Functional dystonia patients exhibited stimulus‐dependent altered activation in networks involved in motor preparation and execution, spatial cognition, and attentional control. These results support the presence of network dysfunction in functional dystonia. © 2017 International Parkinson and Movement Disorder Society
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Between-group differences in default mode, salience and sensorimotor network areas have been identified in a range of FND populations compared to controls.
“While findings have not been entirely consistent across studies and FND sub-populations, between-group differences in default mode, salience and sensorimotor network areas have been identified in a range FND populations compared to controls.45,207,[209][210][211][212]”
From A new science of emotion: implications for functional neurological disorder (2022) · cites this paper as [211]
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- Authors
- Espay, A. J., Maloney, T., Vannest, J., Norris, M. M., Eliassen, J. C., Neefus, E., Allendorfer, J. B., Chen, R., & Szaflarski, J. P.
- Affiliations
- University of Cincinnati (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Alabama at Birmingham (US)
- University Health Network (CA)
- Corresponding author
- Espay, Alberto J.
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2017-11-10
- Volume
- 33
- Issue
- 1
- Pages
- 136-145
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC5767134
- OpenAlex
- W2767961405
- Cited by
- 69
- References
- 53
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 7
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS065701, 1K23MH092735, K23 NS052468, K01 DA020485)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- functional dystonia, psychogenic movement disorders, emotional processing, emotion recognition, emotional facial expressions, brain network dysfunction, fusiform gyrus, insula, middle temporal gyrus, precuneus, inferior frontal gyrus, cerebellum, motor cortex, attentional control, spatial cognition
- MeSH terms
- Adult, Aged, Brain Mapping, Face, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Psychiatric Status Rating Scales, Psychomotor Performance, Severity of Illness Index, Mood Disorders, Dystonic Disorders, Young Adult
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