Transdiagnostic and Transcultural: Pilot Study of Unified Protocol for Depressive and Anxiety Disorders in Japan
Abstract
Unified protocol (UP) is a transdiagnostic cognitive behavior therapy for emotional disorders. It remains unknown whether UP is applicable for use in non-Western countries and for depressive disorders. We therefore examined its feasibility for a Japanese clinical population using this clinical trial design, which is multicentered, open-labeled, and single-armed (Clinical registry: UMIN000008322). The primary outcome was severity of anxiety symptoms, as assessed using Structured Interview Guide for the Hamilton Anxiety Rating Scale. Secondary outcomes were depressive symptoms, clinical global impression, functioning, quality of life, affectivity, emotion regulation, and adverse events. Of the 28 prospective participants, 17 were eligible and enrolled (depressive disorders=9, anxiety disorders=8). Severity of anxiety symptoms, which decreased significantly after the intervention, remained low for 3months (Hedges' g=1.29, 95% CI=0.56-2.06). Similar tendencies were observed for secondary outcome measures. No severe adverse event occurred. Two participants dropped out of the intervention. High treatment adherence and interrater reliability were confirmed. Results suggest the feasibility of UP in the Japanese context sufficient to warrant a larger clinical trial.
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Some studies testing transdiagnostic interventions in improving positive affect measures are uncontrolled trials.
“or they are uncontrolled trials [50-52].”
From Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial (2021) · cites this paper as [50]
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- Authors
- Ito, M., Horikoshi, M., Kato, N., Oe, Y., Fujisato, H., Nakajima, S., Kanie, A., Miyamae, M., Takebayashi, Y., Horita, R., Usuki, M., Nakagawa, A., & Ono, Y.
- Affiliations
- National Center for Cognitive Behavior Therapy and Research (JP)
- Kanto Junior College (JP)
- Tokyo Medical University (JP)
- National Center of Neurology and Psychiatry (JP)
- The Institute of Statistical Mathematics (JP)
- Gifu University (JP)
- National Disaster Medical Center (JP)
- Keio University (JP)
- Corresponding author
- Ito, Masaya
- ORCID
- Venue
- Behavior Therapy
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 47
- Issue
- 3
- Pages
- 416-430
- ISSN
- 0005-7894 (ISSN-L)
- OpenAlex
- W2283624713
- Cited by
- 39
- References
- 58
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavior Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25705018)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- Unified Protocol, depressive disorders, anxiety disorders, Japanese patients, cross-cultural adaptation, treatment feasibility, anxiety symptom severity, emotion regulation, quality of life, medication adherence, inter-rater reliability
- MeSH terms
- Adult, Anxiety Disorders, Cross-Cultural Comparison, Depressive Disorder, Feasibility Studies, Female, Humans, Japan, Male, Pilot Projects, Cognitive Behavioral Therapy
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