The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Multiple Functions of BCL-2 Family Proteins
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several studies have pointed out that release of cytochrome c in the cytosol requires an ROS-mediated destabilized mitochondrial membrane.72−75”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Autophagy in immunity and inflammation
Levine, B., Mizushima, N., & Virgin, H. W. (2011) · Nature · doi:10.1038/nature09782 · Cited by 3,289
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108 · cited 1×
“2009), and others (Chipuk et al. 2004).”
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252 · cited 1×
“The term apoptosis (Gk: falling off, like a tree leaf ) had been coined some years earlier to refer to deliberate cell death, and thus was applied to the type of cell death blocked by BCL-2 (Kerr et al. 1972; Hockenbery et al. 1991).”
BackgroundCassidy-Stone, A., Chipuk, J. E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M. J., Shaw, J. T., Hinshaw, J. E., Green, D. R., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.019 · Cited by 1,200
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C.-Y., Krauss, S., Ranger, A. M., Robert Datta, S., Greenberg, M. E., Licklider, L. J., Lowell, B. B., et al. (2003) · Nature · doi:10.1038/nature01825 · Cited by 705
Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A. (2001) · Science · doi:10.1126/science.1062257 · Cited by 656
Role of Bax and Bak in mitochondrial morphogenesis
Karbowski, M., Norris, K. L., Cleland, M. M., Jeong, S.-Y., & Youle, R. J. (2006) · Nature · doi:10.1038/nature05111 · Cited by 625
Research works printed but not linked: 194
- Abdelwahid E Rolland S Teng X Conradt B Hardwick JM White K 2010 Mitochondrial involvement in cell death of non-mammalian eukaryotes Biochim Biophys Acta 1813 597 607 20950655 PMC3033473
- Alavian KN Li H Collis L Bonanni L Zeng L Sacchetti S Lazrove E Nabili P Flaherty B Graham M 2011 Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1F0 ATP synthase Nat Cell Biol 13 1224 1233 21926988 PMC3186867
- Altmann M Hammerschmidt W 2005 Epstein–Barr virus provides a new paradigm: A requirement for the immediate inhibition of apoptosis PLoS Biol 3 e404 16277553 PMC1283332
- Aoyagi M Zhai D Jin C Aleshin AE Stec B Reed JC Liddington RC 2007 Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein Protein Sci 16 118 124 17123957 PMC2222835
- Baffy G Miyashita T Williamson JR Reed JC 1993 Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production J Biol Chem 268 6511 6519 8454620
- Banadyga L Gerig J Stewart T Barry M 2007 Fowlpox virus encodes a Bcl-2 homologue that protects cells from apoptotic death through interaction with the pro-apoptotic protein Bak J Virol 81 11032 11045 17686864 PMC2045560
- Banadyga L Veugelers K Campbell S Barry M 2009 The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis J Virol 83 7085 7098 19439472 PMC2704773
- Basanez G Hardwick JM 2008 Unravelling the bcl-2 apoptosis code with a simple model system PLoS Biol 6 e154 18563968 PMC2429952
- Bassik MC Scorrano L Oakes SA Pozzan T Korsmeyer SJ 2004 Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis EMBO J 23 1207 1216 15010700 PMC380968
- Bellows DS Chau BN Lee P Lazebnik Y Burns WH Hardwick JM 2000 Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins J Virol 74 5024 5031 10799576 PMC110854
- Bellows DS Howell M Pearson C Hazlewood SA Hardwick JM 2002 Epstein–Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins J Virol 76 2469 2479 11836425 PMC153809
- Bender CE Fitzgerald P Tait SW Llambi F McStay GP Tupper DO Pellettieri J Alvarado AS Salvesen GS Green DR 2012 Mitochondrial pathway of apoptosis is ancestral in metazoans Proc Natl Acad Sci 109 4904 4909 22416118 PMC3324028
- Berman SB Pineda FJ Hardwick JM 2008 Mitochondrial fission and fusion dynamics: The long and short of it Cell Death Differ 15 1147 1152 18437161 PMC2614113
- Berman SB Chen YB Qi B McCaffery JM Rucker EB 3rd Goebbels S Nave KA Arnold BA Jonas EA Pineda FJ 2009 Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons J Cell Biol 184 707 719 19255249 PMC2686401
- Billen LP Kokoski CL Lovell JF Leber B Andrews DW 2008 Bcl-xL inhibits membrane permeabilization by competing with Bax PLoS Biol 6 e147 18547146 PMC2422857
- Blaineau SV Aouacheria A 2009 BCL2DB: Moving “helix-bundled” BCL-2 family members to their database Apoptosis 14 923 925 19543976
- Boya P Pauleau AL Poncet D Gonzalez-Polo RA Zamzami N Kroemer G 2004 Viral proteins targeting mitochondria: Controlling cell death Biochim Biophys Acta 1659 178 189 15576050
- Breckenridge DG Kang BH Xue D 2009 Bcl-2 Proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans Curr Biol 19 768 773 19327994 PMC2739285
- Chami M Prandini A Campanella M Pinton P Szabadkai G Reed JC Rizzuto R 2004 Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region J Biol Chem 279 54581 54589 15485871
- Chang NC Nguyen M Germain M Shore GC 2010 Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 EMBO J 29 606 618 20010695 PMC2830692
- Chau BN Cheng EH Kerr DA Hardwick JM 2000 Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1 Mol Cell 6 31 40 10949025
- Chen YB Aon MA Hsu YT Soane L Teng X McCaffery JM Cheng WC Qi B Li H Alavian KN 2011 Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential J Cell Biol 195 263 276 21987637 PMC3198165
- Cheng EH Levine B Boise LH Thompson CB Hard-wick JM 1996 Bax-independent inhibition of apoptosis by Bcl-xL Nature 379 554 556 8596636
- Cheng EH Kirsch DG Clem RJ Ravi R Kastan MB Bedi A Ueno K Hardwick JM 1997a Conversion of Bcl-2 to a Bax-like death effector by caspases Science 278 1966 1968 9395403
- Cheng EH Nicholas J Bellows DS Hayward GS Guo HG Reitz MS Hardwick JM 1997b A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak Proc Natl Acad Sci 94 690 694 9012846 PMC19575
- Cheng EH Wei MC Weiler S Flavell RA Mak TW Lindsten T Korsmeyer SJ 2001 BCL-2, BCL-xL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis Mol Cell 8 705 711 11583631
- Cheng EH Sheiko TV Fisher JK Craigen WJ Korsmeyer SJ 2003 VDAC2 inhibits BAK activation and mitochondrial apoptosis Science 301 513 517 12881569
- Cheng WC Berman SB Ivanovska I Jonas EA Lee SJ Chen Y Kaczmarek LK Pineda F Hardwick JM 2006 Mitochondrial factors with dual roles in death and survival Oncogene 25 4697 4705 16892083
- Chou JJ Li H Salvesen GS Yuan J Wagner G 1999 Solution structure of BID, an intracellular amplifier of apoptotic signaling Cell 96 615 624 10089877
- Clem RJ Cheng EH Karp CL Kirsch DG Ueno K Takahashi A Kastan MB Griffin DE Earnshaw WC Veliuona MA 1998 Modulation of cell death by Bcl-xL through caspase interaction Proc Natl Acad Sci 95 554 559 9435230 PMC18458
- Condorelli F Salomoni P Cotteret S Cesi V Srinivasula SM Alnemri ES Calabretta B 2001 Caspase cleavage enhances the apoptosis-inducing effects of BAD Mol Cell Biol 21 3025 3036 11287608 PMC86931
- Cooray S Bahar MW Abrescia NG McVey CE Bartlett NW Chen RA Stuart DI Grimes JM Smith GL 2007 Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein J Gen Virol 88 1656 1666 17485524 PMC2885619
- Cosulich SC Worrall V Hedge PJ Green S Clarke PR 1997 Regulation of apoptosis by BH3 domains in a cell-free system Curr Biol 7 913 920 9382837
- Cuconati A White E 2002 Viral homologs of BCL-2: Role of apoptosis in the regulation of virus infection Genes Dev 16 2465 2478 12368257
- Danial NN Gimenez-Cassina A Tondera D 2010 Homeostatic functions of BCL-2 proteins beyond apoptosis Adv Exp Med Biol 687 1 32 20919635
- Datta SR Dudek H Tao X Masters S Fu H Gotoh Y Greenberg ME 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 231 241 9346240
- Deckwerth TL Elliott JL Knudson CM Johnson EM Jr Snider WD Korsmeyer SJ 1996 BAX is required for neuronal death after trophic factor deprivation and during development Neuron 17 401 411 8816704
- Degenhardt K Perez D White E 2000 Pathways used by adenovirus E1B 19K to inhibit apoptosis Symp Soc Exp Biol 52 241 251 12090012
- Delivani P Adrain C Taylor RC Duriez PJ Martin SJ 2006 Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics Mol Cell 21 761 773 16543146
- Deng J Carlson N Takeyama K Dal Cin P Shipp M Letai A 2007 BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents Cancer Cell 12 171 185 17692808
- Diwan A Koesters AG Capella D Geiger H Kalfa TA Dorn GW II 2008 Targeting erythroblast-specific apoptosis in experimental anemia Apoptosis 13 1022 1030 18584327 PMC2556039
- Douglas AE Corbett KD Berger JM McFadden G Handel TM 2007 Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2 Protein Sci 16 695 703 17384234 PMC2203349
- Dremina ES Sharov VS Kumar K Zaidi A Michaelis EK Schoneich C 2004 Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) Biochem J 383 361 370 15245329 PMC1134078
- EX Hwang S Oh S Lee JS Jeong JH Gwack Y Kowalik TF Sun R Jung JU Liang C 2009 Viral Bcl-2-mediated evasion of autophagy aids chronic infection of γherpesvirus 68 PLoS Pathog 5 e1000609 19816569 PMC2752191
- Eckenrode EF Yang J Velmurugan GV Foskett JK White C 2010 Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling J Biol Chem 285 13678 13684 20189983 PMC2859530
- Eliseev RA Malecki J Lester T Zhang Y Humphrey J Gunter TE 2009 Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect J Biol Chem 284 9692 9699 19228691 PMC2665090
- Erlich S Mizrachy L Segev O Lindenboim L Zmira O Adi-Harel S Hirsch JA Stein R Pinkas-Kramarski R 2007 Differential interactions between Beclin 1 and Bcl-2 family members Autophagy 3 561 568 17643073
- Fannjiang Y Kim CH Huganir RL Zou S Lindsten T Thompson CB Mito T Traystman RJ Larsen T Griffin DE 2003 BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development Dev Cell 4 575 585 12689595
- Frank S 2006 Dysregulation of mitochondrial fusion and fission: An emerging concept in neurodegeneration Acta Neuropathol 111 93 100 16468021
- Frank S Gaume B Bergmann-Leitner ES Leitner WW Robert EG Catez F Smith CL Youle RJ 2001 The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis Dev Cell 1 515 525 11703942
- Galindo KA Lu WJ Park JH Abrams JM 2009 The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death Development (Cambridge, England) 136 275 283 PMC2685970 19088092
- Garcia I Crowther AJ Gama V Ryan Miller C Deshmukh M Gershon TR 2012 Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation Oncogene 10.1038/onc.2012.248 PMC3449008 22710714 · DOI
- Germain M Slack RS 2011 MCL-1 regulates the balance between autophagy and apoptosis Autophagy 7 549 551 21412051
- Gimenez-Cassina A Martinez-Francois JR Fisher JK Szlyk B Polak K Wiwczar J Tanner GR Lutas A Yellen G Danial NN 2012 BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures Neuron 74 719 730 22632729 PMC3361694
- Glebova NO Ginty DD 2004 Heterogeneous requirement of NGF for sympathetic target innervation in vivo J Neurosci 24 743 751 14736860 PMC6729267
- Gocnikova H Russ G 2007 Influenza a virus PB1-F2 protein Acta Virol 51 101 108 17900216
- Gonzalez JM Esteban M 2010 A poxvirus Bcl-2-like gene family involved in regulation of host immune response: Sequence similarity and evolutionary history Virol J 7 59 20230632 PMC2907574
- Gonzalez-Estevez C Salo E 2010 Autophagy and apoptosis in planarians Apoptosis 15 279 292 20069458
- Gotow T Shibata M Kanamori S Tokuno O Ohsawa Y Sato N Isahara K Yayoi Y Watanabe T Leterrier JF 2000 Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells Cell Death Differ 7 666 674 10889511
- Graham SC Bahar MW Cooray S Chen RA Whalen DM Abrescia NG Alderton D Owens RJ Stuart DI Smith GL 2008 Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-κB rather than apoptosis PLoS Pathog 4 e1000128 18704168 PMC2494871
- Gross A Yin XM Wang K Wei MC Jockel J Milliman C Erdjument-Bromage H Tempst P Korsmeyer SJ 1999 Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-xL prevents this release but not tumor necrosis factor-R1/Fas death J Biol Chem 274 1156 1163 9873064
- Guo JY Yamada A Kajino T Wu JQ Tang W Freel CD Feng J Chau BN Wang MZ Margolis SS 2008 Aven-dependent activation of ATM following DNA damage Curr Biol 18 933 942 18571408 PMC2691717
- Hardwick JM Chen YB Jonas EA 2012 Multipolar functions of BCL-2 proteins link energetics to apoptosis Trends Cell Biol 22 318 328 22560661 PMC3499971
- He C Levine B 2010 The Beclin 1 interactome Curr Opin Cell Biol 22 140 149 20097051 PMC2854269
- Henderson S Huen D Rowe M Dawson C Johnson G Rickinson A 1993 Epstein–Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death Proc Natl Acad Sci 90 8479 8483 8397406 PMC47380
- Hengartner MO Horvitz HR 1994a Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2 Nature 369 318 320 7910376
- Hengartner MO Horvitz HR 1994b C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 Cell 76 665 676 7907274
- Hengartner MO Ellis RE Horvitz HR 1992 Caenorhabditis elegans gene ced-9 protects cells from programmed cell death Nature 356 494 499 1560823
- Hickman JA Hardwick JM Kaczmarek LK Jonas EA 2008a Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission J Neurophysiol 99 1515 1522 18160428 PMC2836590
- Hickman JA Hardwick JM Kaczmarek LK Jonas EA 2008b Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission J Neurophysiol 99 1515 1522 18160428 PMC2836590
- Hinds MG Smits C Fredericks-Short R Risk JM Bailey M Huang DC Day CL 2007 Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets Cell Death Differ 14 128 136 16645638
- Hoppins S Edlich F Cleland MM Banerjee S Mc-Caffery JM Youle RJ Nunnari J 2011 The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes Mol Cell 41 150 160 21255726 PMC3072068
- Horvitz HR Sternberg PW Greenwald IS Fixsen W Ellis HM 1983 Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans Cold Spring Harb Symp Quant Biol 48 453 463 6586368
- Huang DC Strasser A 2000 BH3-Only proteins-essential initiators of apoptotic cell death Cell 103 839 842 11136969
- Huang CR Yang-Yen HF 2010 The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity FEBS Lett 584 3323 3330 20627101
- Irusta PM Chen YB Hardwick JM 2003 Viral modulators of cell death provide new links to old pathways Curr Opin Cell Biol 15 700 705 14644194
- Jagasia R Grote P Westermann B Conradt B 2005 DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans Nature 433 754 760 15716954
- Jiao S Li Z 2011 Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission Neuron 70 758 772 21609830 PMC3102234
- Jonas EA Hoit D Hickman JA Brandt TA Polster BM Fannjiang Y McCarthy E Montanez MK Hardwick JM Kaczmarek LK 2003 Modulation of synaptic transmission by the BCL-2 family protein BCL-xL J Neurosci 23 8423 8431 12968005 PMC6740692
- Jonas EA Hickman JA Chachar M Polster BM Brandt TA Fannjiang Y Ivanovska I Basanez G Kinnally KW Zimmerberg J 2004 Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals Proc Natl Acad Sci 101 13590 13595 15342906 PMC518799
- Jonas EA Hardwick JM Kaczmarek LK 2005a Actions of BAX on mitochondrial channel activity and on synaptic transmission Antioxid Redox Signal 7 1092 1100 16115013
- Jonas EA Hickman JA Hardwick JM Kaczmarek LK 2005b Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse J Biol Chem 280 4491 4497 15561723
- Jurgensmeier JM Xie Z Deveraux Q Ellerby L Bredesen D Reed JC 1998 Bax directly induces release of cytochrome c from isolated mitochondria Proc Natl Acad Sci 95 4997 5002 9560217 PMC20202
- Kalverda AP Thompson GS Vogel A Schroder M Bowie AG Khan AR Homans SW 2009 Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD box RNA helicase DDX3 J Mol Biol 385 843 853 18845156
- Kang R Zeh HJ Lotze MT Tang D 2011 The Beclin 1 network regulates autophagy and apoptosis Cell Death Differ 18 571 580 21311563 PMC3131912
- Karbowski M Lee YJ Gaume B Jeong SY Frank S Nechushtan A Santel A Fuller M Smith CL Youle RJ 2002 Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis J Cell Biol 159 931 938 12499352 PMC2173996
- Kelekar A Chang BS Harlan JE Fesik SW Thompson CB 1997 Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-xL Mol Cell Biol 17 7040 7046 9372935 PMC232560
- Kerr JF Wyllie AH Currie AR 1972 Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26 239 257 4561027 PMC2008650
- Kim CN Wang X Huang Y Ibrado AM Liu L Fang G Bhalla K 1997 Overexpression of Bcl-xL inhibits Ara- C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis Cancer Res 57 3115 3120 9242435
- Kim BC Mamura M Choi KS Calabretta B Kim SJ 2002 Transforming growth factor β1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells Mol Cell Biol 22 1369 1378 11839804 PMC134700
- Kluck RM Esposti MD Perkins G Renken C Kuwana T Bossy-Wetzel E Goldberg M Allen T Barber MJ Green DR 1999 The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol J Cell Biol 147 809 822 10562282 PMC2156156
- Knott AB Perkins G Schwarzenbacher R Bossy-Wetzel E 2008 Mitochondrial fragmentation in neurodegeneration Nat Rev Neurosci 9 505 518 18568013 PMC2711514
- Korsmeyer SJ Shutter JR Veis DJ Merry DE Oltvai ZN 1993 Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death Semin Cancer Biol 4 327 332 8142617
- Ku B Woo JS Liang C Lee KH Hong HSEX Kim KS Jung JU Oh BH 2008 Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine γ-herpesvirus 68 PLoS Pathog 4 e25 18248095 PMC2222952
- Kuida K Zheng TS Na S Kuan C Yang D Karasuyama H Rakic P Flavell RA 1996 Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice Nature 384 368 372 8934524
- Kuida K Haydar TF Kuan CY Gu Y Taya C Karasuyama H Su MS Rakic P Flavell RA 1998 Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9 Cell 94 325 337 9708735
- Kuwana T Mackey MR Perkins G Ellisman MH Latterich M Schneiter R Green DR Newmeyer DD 2002 Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane Cell 111 331 342 12419244
- Kvansakul M Yang H Fairlie WD Czabotar PE Fischer SF Perugini MA Huang DC Colman PM 2008 Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands Cell Death Differ 15 1564 1571 18551131
- Labrousse AM Zappaterra MD Rube DA van der Bliek AM 1999 C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane Mol Cell 4 815 826 10619028
- Landes T Martinou JC 2011 Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission Biochim Biophys Acta 1813 540 545 21277336
- Levi-Montalcini R Angeletti PU 1968 Nerve growth factor Phys Rev 48 534 569 4875350
- Levine B Sinha S Kroemer G 2008 Bcl-2 family members: Dual regulators of apoptosis and autophagy Autophagy 4 600 606 18497563 PMC2749577
- Lewis J Oyler GA Ueno K Fannjiang YR Chau BN Vornov J Korsmeyer SJ Zou S Hardwick JM 1999 Inhibition of virus-induced neuronal apoptosis by Bax Nat Med 5 832 835 10395331
- Li Z Sheng M 2012 Caspases in synaptic plasticity Mol Brain 5 15 22583788 PMC3366905
- Li H Zhu H Xu CJ Yuan J 1998 Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 491 501 9727492
- Li H Chen Y Jones AF Sanger RH Collis LP Flannery R McNay EC Yu T Schwarzenbacher R Bossy B 2008 Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons Proc Natl Acad Sci 105 2169 2174 18250306 PMC2542873
- Lindsten T Ross AJ King A Zong WX Rathmell JC Shiels HA Ulrich E Waymire KG Mahar P Frauwirth K 2000 The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues Mol Cell 6 1389 1399 11163212 PMC3057227
- Liu Y Vaithiyalingam S Shi Q Chazin WJ Zinkel SS 2011 BID binds to replication protein A and stimulates ATR function following replicative stress Mol Cell Biol 31 4298 4309 21859891 PMC3209332
- Lovell JF Billen LP Bindner S Shamas-Din A Fradin C Leber B Andrews DW 2008 Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax Cell 135 1074 1084 19062087
- Lowman XH McDonnell MA Kosloske A Odumade OA Jenness C Karim CB Jemmerson R Kelekar A 2010 The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose Mol Cell 40 823 833 21145489
- Luo X Budihardjo I Zou H Slaughter C Wang X 1998 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cell 94 481 490 9727491
- Luo X He Q Huang Y Sheikh MS 2005 Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation Cell Death Differ 12 1310 1318 15905879
- Maiuri MC Criollo A Tasdemir E Vicencio JM Tajeddine N Hickman JA Geneste O Kroemer G 2007a BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-xL Autophagy 3 374 376 17438366
- Maiuri MC Le Toumelin G Criollo A Rain JC Gautier F Juin P Tasdemir E Pierron G Troulinaki K Tavernarakis N 2007b Functional and physical interaction between Bcl-xL and a BH3-like domain in Beclin-1 EMBO J 26 2527 2539 17446862 PMC1868901
- Malik SA Shen S Marino G Benyounes A Maiuri MC Kroemer G 2011 BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades Autophagy 7 21508685
- Marty A Llano I 2005 Excitatory effects of GABA in established brain networks Trend Neurosci 28 284 289 15927683
- Mathai JP Germain M Shore GC 2005 BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death J Biol Chem 280 23829 23836 15809295
- McDonnell JM Fushman D Milliman CL Korsmeyer SJ Cowburn D 1999 Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists Cell 96 625 634 10089878
- Meeusen SL Nunnari J 2007 Mitochondrial fusion in vitro Methods Mol Biol 372 461 466 18314745
- Minn AJ Velez P Schendel SL Liang H Muchmore SW Fesik SW Fill M Thompson CB 1997 Bcl-xL forms an ion channel in synthetic lipid membranes Nature 385 353 357 9002522
- Minn AJ Kettlun CS Liang H Kelekar A Vander Heiden MG Chang BS Fesik SW Fill M Thompson CB 1999 Bcl-xL regulates apoptosis by heterodimerization- dependent and -independent mechanisms EMBO J 18 632 643 9927423 PMC1171156
- Montessuit S Somasekharan SP Terrones O Lucken-Ardjomande S Herzig S Schwarzenbacher R Manstein DJ Bossy-Wetzel E Basanez G Meda P 2010 Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization Cell 142 889 901 20850011 PMC4115189
- Moretti L Attia A Kim KW Lu B 2007 Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy Autophagy 3 142 144 17204849
- Muchmore SW Sattler M Liang H Meadows RP Harlan JE Yoon HS Nettesheim D Chang BS Thompson CB Wong SL 1996 X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death Nature 381 335 341 8692274
- Nava VE Cheng EH Veliuona M Zou S Clem RJ Mayer ML Hardwick JM 1997 Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene J Virol 71 4118 4122 9094693 PMC191568
- Nunez G Seto M Seremetis S Ferrero D Grignani F Korsmeyer SJ Dalla-Favera R 1989 Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells Proc Natl Acad Sci 86 4589 4593 2543982 PMC287316
- Oakes SA Scorrano L Opferman JT Bassik MC Nishino M Pozzan T Korsmeyer SJ 2005 Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum Proc Natl Acad Sci 102 105 110 15613488 PMC544078
- Oakes SA Lin SS Bassik MC 2006 The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins Curr Mol Med 6 99 109 16472117
- Oberst A Bender C Green DR 2008 Living with death: The evolution of the mitochondrial pathway of apoptosis in animals Cell Death Differ 15 1139 1146 18451868 PMC2612587
- Oberstein A Jeffrey PD Shi Y 2007 Crystal structure of the Bcl-xL-Beclin 1 peptide complex: Beclin 1 is a novel BH3- only protein J Biol Chem 282 13123 13132 17337444
- Ofengeim D Chen YB Miyawaki T Li H Sacchetti S Flannery RJ Alavian KN Pontarelli F Roelofs BA Hickman JA 2012 N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death Nat Neurosci 15 574 580 22366758 PMC3862259
- Oltersdorf T Elmore SW Shoemaker AR Armstrong RC Augeri DJ Belli BA Bruncko M Deckwerth TL Dinges J Hajduk PJ 2005 An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 677 681 15902208
- Oltvai ZN Milliman CL Korsmeyer SJ 1993 Bcl-2 hetero-dimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 609 619 8358790
- Palmer AE Jin C Reed JC Tsien RY 2004 Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor Proc Natl Acad Sci 101 17404 17409 15585581 PMC535104
- Parone PA James DI Da Cruz S Mattenberger Y Donze O Barja F Martinou JC 2006 Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis Mol Cell Biol 26 7397 7408 17015472 PMC1636857
- Pattingre S Tassa A Qu X Garuti R Liang XH Mizushima N Packer M Schneider MD Levine B 2005 Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy Cell 122 927 939 16179260
- Perciavalle RM Stewart DP Koss B Lynch J Milasta S Bathina M Temirov J Cleland MM Pelletier S Schuetz JD 2012 Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration Nat Cell Biol 14 575 583 22544066 PMC3401947
- Perez D White E 2000 TNF-α signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K Mol Cell 6 53 63 10949027
- Peter ME 2011 Programmed cell death: Apoptosis meets necrosis Nature 471 310 312 21412328
- Peterson JS Bass BP Jue D Rodriguez A Abrams JM McCall K 2007 Noncanonical cell death pathways act during Drosophila oogenesis Genesis 45 396 404 17506088
- Petros AM Nettesheim DG Wang Y Olejniczak ET Meadows RP Mack J Swift K Matayoshi ED Zhang H Thompson CB 2000 Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies Protein Sci 9 2528 2534 11206074 PMC2144516
- Pinton P Rizzuto R 2006 Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum Cell Death Differ 13 1409 1418 16729032
- Popgeorgiev N Bonneau B Ferri KF Prudent J Thibaut J Gillet G 2011 The apoptotic regulator Nrz controls cytoskeletal dynamics via the regulation of Ca2+ trafficking in the zebrafish blastula Dev Cell 20 663 676 21571223
- Rao L Debbas M Sabbatini P Hockenbery D Korsmeyer S White E 1992 The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins Proc Natl Acad Sci 89 7742 7746 1457005 PMC49787
- Ren D Tu HC Kim H Wang GX Bean GR Takeuchi O Jeffers JR Zambetti GP Hsieh JJ Cheng EH 2010 BID, BIM, and PUMA are essential for activation of the BAX-and BAK-dependent cell death program Science 330 1390 1393 21127253 PMC3163443
- Roelofs BA Hardwick JM 2011 Flying to a halt: Drosophila Aven arrests the cell cycle Cell cycle 10 1351 1352 21487234 PMC3356827
- Rolland SG Lu Y David CN Conradt B 2009 The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion J Cell Biol 186 525 540 19704021 PMC2733758
- Rong YP Aromolaran AS Bultynck G Zhong F Li X McColl K Matsuyama S Herlitze S Roderick HL Bootman MD 2008 Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2’s inhibition of apoptotic calcium signals Mol Cell 31 255 265 18657507 PMC3660092
- Rong YP Barr P Yee VC Distelhorst CW 2009 Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor Biochim Biophys Acta 1793 971 978 19056433 PMC3674874
- Rosse T Olivier R Monney L Rager M Conus S Fellay I Jansen B Borner C 1998 Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c Nature 391 496 499 9461218
- Roy SS Madesh M Davies E Antonsson B Danial N Hajnoczky G 2009 Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death Mol Cell 33 377 388 19217411 PMC2662194
- Samara NL Datta AB Berndsen CE Zhang X Yao T Cohen RE Wolberger C 2010 Structural insights into the assembly and function of the SAGA deubiquitinating module Science 328 1025 1029 20395473 PMC4220450
- Scorrano L Ashiya M Buttle K Weiler S Oakes SA Mannella CA Korsmeyer SJ 2002 A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis Dev Cell 2 55 67 11782314
- Scorrano L Oakes SA Opferman JT Cheng EH Sorcinelli MD Pozzan T Korsmeyer SJ 2003 BAX and BAK regulation of endoplasmic reticulum Ca2+: A control point for apoptosis Science 300 135 139 12624178
- Seo SY Chen YB Ivanovska I Ranger AM Hong SJ Dawson VL Korsmeyer SJ Bellows DS Fannjiang Y Hardwick JM 2004 BAD is a pro-survival factor prior to activation of its pro-apoptotic function J Biol Chem 279 42240 42249 15231831 PMC4591964
- Seto E Moosmann A Gromminger S Walz N Grundhoff A Hammerschmidt W 2010 Micro RNAs of Epstein–Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells PLoS Pathog 6 PMC2924374 20808852
- Shamas-Din A Brahmbhatt H Leber B Andrews DW 2011 BH3-only proteins: Orchestrators of apoptosis Biochim Biophysica Acta 1813 508 520 21146563
- Shaw JM Nunnari J 2002 Mitochondrial dynamics and division in budding yeast Trend Cell Biol 12 178 184 PMC3785940 11978537
- Shimazu T Degenhardt K Nur EKA Zhang J Yoshida T Zhang Y Mathew R White E Inouye M 2007 NBK/BIK antagonizes MCL-1 and BCL-xL and activates BAK-mediated apoptosis in response to protein synthesis inhibition Genes Dev 21 929 941 17403773 PMC1847711
- Sinha S Colbert CL Becker N Wei Y Levine B 2008 Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11 Autophagy 4 989 997 18797192 PMC2755179
- Stack J Haga IR Schroder M Bartlett NW Maloney G Reading PC Fitzgerald KA Smith GL Bowie AG 2005 Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence J Exp Med 201 1007 1018 15767367 PMC2213104
- Strappazzon F Vietri-Rudan M Campello S Nazio F Florenzano F Fimia GM Piacentini M Levine B Cecconi F 2011 Mitochondrial BCL-2 inhibits AM-BRA1-induced autophagy EMBO J 30 1195 1208 21358617 PMC3094111
- Strasser A 2005 The role of BH3-only proteins in the immune system Nat Rev 5 189 200 15719025
- Strasser A Puthalakath H Bouillet P Huang DC O’Connor L O’Reilly LA Cullen L Cory S Adams JM 2000 The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control Ann NY Acad Sci 917 541 548 11268382
- Su J Wang G Barrett JW Irvine TS Gao X McFadden G 2006 Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria J Virol 80 1140 1151 16414991 PMC1346952
- Sun W Winseck A Vinsant S Park OH Kim H Oppenheim RW 2004 Programmed cell death of adult-generated hippocampal neurons is mediated by the pro-apoptotic gene Bax J Neurosci 24 11205 11213 15590937 PMC6730275
- Tan FJ Husain M Manlandro CM Koppenol M Fire AZ Hill RB 2008 CED-9 and mitochondrial homeostasis in C. elegans muscle J Cell Sci 121 3373 3382 18827010 PMC2785848
- Tanner EA Blute TA Brachmann CB McCall K 2011 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary Development 138 327 338 21177345 PMC3005606
- Taylor JM Quilty D Banadyga L Barry M 2006 The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax J Biol Chem 281 39728 39739 17074758
- Tse C Shoemaker AR Adickes J Anderson MG Chen J Jin S Johnson EF Marsh KC Mitten MJ Nimmer P 2008 ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor Cancer Res 68 3421 3428 18451170
- Tsujimoto Y 1989 Overexpression of the human BCL-2 gene product results in growth enhancement of Ep-stein–Barr virus-immortalized B cells Proc Natl Acad Sci 86 1958 1962 2538824 PMC286824
- Tsujimoto Y Finger LR Yunis J Nowell PC Croce CM 1984 Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation Science 226 1097 1099 6093263
- Tsujimoto Y Cossman J Jaffe E Croce CM 1985 Involvement of the bcl-2 gene in human follicular lymphoma Science 228 1440 1443 3874430
- Vanden Abeele F Skryma R Shuba Y Van Coppenolle F Slomianny C Roudbaraki M Mauroy B Wuytack F Prevarskaya N 2002 Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells Cancer Cell 1 169 179 12086875
- Vander Heiden MG Li XX Gottleib E Hill RB Thompson CB Colombini M 2001 Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane J Biol Chem 276 19414 19419 11259441
- Vaseva AV Marchenko ND Ji K Tsirka SE Holzmann S Moll UM 2012 p53 Opens the mitochondrial permeability transition pore to trigger necrosis Cell 149 1536 1548 22726440 PMC3383624
- Vaux DL Cory S Adams JM 1988 Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells Nature 335 440 442 3262202
- Vento MT Zazzu V Loffreda A Cross JR Downward J Stoppelli MP Iaccarino I 2010 Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells PLoS ONE 5 e15636 21203533 PMC3006391
- Wang K Yin XM Chao DT Milliman CL Korsmeyer SJ 1996 BID: A novel BH3 domain-only death agonist Genes Dev 10 2859 2869 8918887
- Warr MR Mills JR Nguyen M Lemaire-Ewing S Baardsnes J Sun KL Malina A Young JC Jeyaraju DV O’Connor-McCourt M 2011 Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site J Biol Chem 286 25098 25107 21613222 PMC3137083
- Wasilenko ST Stewart TL Meyers AF Barry M 2003 Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis Proc Natl Acad Sci 100 14345 14350 14610284 PMC283594
- Westphal D Ledgerwood EC Hibma MH Fleming SB Whelan EM Mercer AA 2007 A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus J Virol 81 7178 7188 17475653 PMC1933275
- Whelan RS Konstantinidis K Wei AC Chen Y Reyna DE Jha S Yang Y Calvert JW Lindsten T Thompson CB 2012 Bax regulates primary necrosis through mitochondrial dynamics Proc Natl Acad Sci 109 6566 6571 22493254 PMC3340068
- White C Li C Yang J Petrenko NB Madesh M Thompson CB Foskett JK 2005 The endoplasmic reticulum gateway to apoptosis by Bcl-xL modulation of the InsP3R Nat Cell Biol 7 1021 1028 16179951 PMC2893337
- Whitmore AV Lindsten T Raff MC Thompson CB 2003 The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration Cell Death Differ 10 260 261 12700655
- Yecies D Carlson NE Deng J Letai A 2010 Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1 Blood 115 3304 3313 20197552 PMC2858493
- Yee KS Wilkinson S James J Ryan KM Vousden KH 2009 PUMA- and Bax-induced autophagy contributes to apoptosis Cell Death Differ 16 1135 1145 19300452 PMC2711052
- Yeretssian G Correa RG Doiron K Fitzgerald P Dillon CP Green DR Reed JC Saleh M 2011 Non-apoptotic role of BID in inflammation and innate immunity Nature 474 96 99 21552281
- Yoshida H Kong YY Yoshida R Elia AJ Hakem A Hakem R Penninger JM Mak TW 1998 Apaf1 is required for mitochondrial pathways of apoptosis and brain development Cell 94 739 750 9753321
- Yuan JY Horvitz HR 1990 The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death Dev Biol 138 33 41 2307287
- Yuan J Shaham S Ledoux S Ellis HM Horvitz HR 1993 The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme Cell 75 641 652 8242740
- Zheng TS Hunot S Kuida K Momoi T Srinivasan A Nicholson DW Lazebnik Y Flavell RA 2000 Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation Nat Med 6 1241 1247 11062535
- Zinkel SS Hurov KE Ong C Abtahi FM Gross A Korsmeyer SJ 2005 A role for proapoptotic BID in the DNA-damage response Cell 122 579 591 16122425
- Zou S Chang J LaFever L Tang W Johnson EL Hu J Wilk R Krause HM Drummond-Barbosa D Irusta PM 2011 Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven Cell Cycle 10 989 998 21368576 PMC3100878
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationMechanisms of Action of Bcl-2 Family Proteins
Shamas-Din, A., Kale, J., Leber, B., & Andrews, D. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008714 · Cited by 705
Emran, T. B., Shahriar, A., Mahmud, A. R., Rahman, T., Abir, M. H., Siddiquee, M. F. R., Ahmed, H., Rahman, N., Nainu, F., Wahyudin, E., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891652 · Cited by 606
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451
Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation
Birkinshaw, R. W., & Czabotar, P. E. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.04.001 · Cited by 229
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
Charan, R. A., Johnson, B. N., Zaganelli, S., Nardozzi, J. D., & LaVoie, M. J. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.278 · Cited by 67
Mishra, S., das, K., Chatterjee, S., Sahoo, P., Kundu, S., Pal, M., Bhaumik, A., & Ghosh, C. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c04964 · Cited by 65
Lucantoni, F., Dussmann, H., & Prehn, J. H. M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00113 · Cited by 47
“However, it is now becoming increasingly evident, that BCL-2 family proteins also regulate mitochondrial fusion and fission dynamics and may regulate mitochondrial respiratory chain activity (Chen and Pervaiz, 2007; Alavian et al., 2011; Hardwick and Soane, 2013; Gross, 2016; Williams et al., 2016).”
BackgroundOu, H., Chou, W., Chu, P., Hsieh, P., Hung, C., & Tsai, K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801353 · Cited by 41
The Incomplete Puzzle of the BCL2 Proteins
Flores-Romero, H., & García-Sáez, A. J. (2019) · Cells · doi:10.3390/cells8101176 · Cited by 38
An OX-Tra’Ordinary tale: the role of OX40 and OX40L in atopic dermatitis
Sadrolashrafi, K., Guo, L., Kikuchi, R., Hao, A., Yamamoto, R. K., Tolson, H. C., Bilimoria, S. N., Yee, D. K., & Armstrong, A. W. (2024) · Cells · doi:10.3390/cells13070587 · Cited by 28
Qiu, F., He, S., Zhang, Z., Dai, S., Wang, J., Liu, N., Li, Z., Hu, X., Xiang, S., & Wei, C. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113888 · Cited by 16
Metadata
- Authors
- Hardwick, J. M., & Soane, L.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 5
- Issue
- 2
- Pages
- a008722-a008722
- ISSN
- 1943-0264
- PMC
- PMC3552500
- Cited by
- 564
- References
- 13
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review