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Cited by 313

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

Open access
Nistico, P., Bissell, M. J., Radisky, D. C.·2012·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a011908
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Abstract

Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells acquire the motile and invasive characteristics of mesenchymal cells. Although EMT in embryonic development is a coordinated, organized process involving interaction between many different cells and tissue types, aspects of the EMT program can be inappropriately activated in response to microenvironmental alterations and aberrant stimuli, and this can contribute to disease conditions including tissue fibrosis and cancer progression. Here we will outline how EMT functions in normal development, how it could be activated in pathologic conditions-especially by matrix metalloproteinases-and how it may be targeted for therapeutic benefit.

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Metadata

Authors
Nistico, P., Bissell, M. J., & Radisky, D. C.
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2012-02-01
Volume
4
Issue
2
Pages
a011908-a011908
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a011908
OpenAlex
W2139241071
Cited by
313
References
103
Type
posted content
Language
en
Open access
bronze

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