Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

The Role of Chromatin during Transcription

Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503

The ENCODE (ENCyclopedia Of DNA Elements) Project

(2004) · Science · doi:10.1126/science.1105136 · Cited by 2,390

Position-independent, high-level expression of the human β-globin gene in transgenic mice

Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908

The UCSC Genome Browser Database

Karolchik, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg129 · Cited by 1,890

A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T., Luo, B., Grenier, J. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.040 · Cited by 1,804

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., & de Laat, W. (2006) · Nature Genetics · doi:10.1038/ng1896 · Cited by 1,386

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919

From head to toes: the multiple facets of Sox proteins

Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Xu, K., Wu, Z. J., Groner, A. C., He, H. H., Cai, C., Lis, R. T., Wu, X., Stack, E. C., Loda, M. F., Liu, T., et al. (2012) · Science · doi:10.1126/science.1227604 · Cited by 901

Defining functional DNA elements in the human genome

Kellis, M., Wold, B. J., Snyder, M. P., Bernstein, B., Kundaje, A. B., Marinov, G. K., Ward, L. D., Birney, E., Crawford, G. E., Dekker, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318948111 · Cited by 724

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science · doi:10.1126/science.1242088 · Cited by 653

Genetics of Human Cardiovascular Disease

Kathiresan, S., & Srivastava, D. (2012) · Cell · doi:10.1016/j.cell.2012.03.001 · Cited by 513

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.016 · Cited by 478

Reactivation of developmentally silenced globin genes by forced chromatin looping

Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.050 · Cited by 443

Primitive and definitive erythropoiesis in mammals

Palis, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00003 · Cited by 442

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

Ni, M., Chen, Y., Lim, E., Wimberly, H., Bailey, S. T., Imai, Y., Rimm, D. L., Liu, X. S., & Brown, M. A. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.026 · Cited by 401

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science · doi:10.1126/science.aad3312 · Cited by 373

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

Zhou, D., Liu, K., Sun, C.-W., Pawlik, K. M., & Townes, T. M. (2010) · Nature Genetics · doi:10.1038/ng.637 · Cited by 367

The switch from fetal to adult hemoglobin.

Sankaran, V. G., & Orkin, S. H. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011643 · Cited by 333

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science · doi:10.1126/science.1211053 · Cited by 326

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Xie, H., Xu, J., Hsu, J. H.-R., Nguyen, M., Fujiwara, Y., Peng, C., & Orkin, S. H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.001 · Cited by 334

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Martyn, G. E., Wienert, B., Yang, L., Shah, M., Norton, L. J., Burdach, J., Kurita, R., Nakamura, Y., Pearson, R. C. M., Funnell, A. P. W., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0085-0 · Cited by 300

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

Sun, X., Wang, S. C., Wei, Y., Luo, X., Jia, Y., Li, L., Gopal, P., Zhu, M., Nassour, I., Chuang, J.-C., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.007 · Cited by 260

Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A

Mimura, I., Nangaku, M., Kanki, Y., Tsutsumi, S., Inoue, T., Kohro, T., Yamamoto, S., Fujita, T., Shimamura, T., Suehiro, J.-I., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06643-11 · Cited by 251

Transcription factor networks in erythroid cell and megakaryocyte development

Doré, L. C., & Crispino, J. D. (2011) · Blood · doi:10.1182/blood-2011-04-285981 · Cited by 251

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303976110 · Cited by 233

Bcl11a is essential for lymphoid development and negatively regulates p53

Yu, Y., Wang, J., Khaled, W. T., Burke, S., Li, P., Chen, X., Yang, W., Jenkins, N. A., Copeland, N. G., Zhang, S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121846 · Cited by 223

CD4 Helper and CD8 Cytotoxic T Cell Differentiation

Taniuchi, I. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053411 · Cited by 249

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

Wilber, A. C., Nienhuis, A. W., & Persons, D. A. (2011) · Blood · doi:10.1182/blood-2010-11-316893 · Cited by 226

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

Lessard, S., Beaudoin, M., Benkirane, K., & Lettre, G. (2015) · Genome Medicine · doi:10.1186/s13073-014-0122-2 · Cited by 218

Molecular basis of β thalassemia and potential therapeutic targets

Thein, S. L. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.06.001 · Cited by 219

A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data

Lu, Q., Hu, Y., Sun, J., Cheng, Y., Cheung, K., & Zhao, H. (2015) · Scientific Reports · doi:10.1038/srep10576 · Cited by 197

Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis

Xu, J., Shao, Z., Glass, K., Bauer, D. E., Pinello, L., Handel, B. V., Hou, S., Stamatoyannopoulos, J. A., Mikkola, H. K. A., Yuan, G., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.003 · Cited by 207

The nucleosome remodeling and deacetylase complex in development and disease

Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191

A Functional Element Necessary for Fetal Hemoglobin Silencing

Sankaran, V. G., Xu, J., Byron, R., Greisman, H. A., Fisher, C. A., Weatherall, D. J., Sabath, D. E., Groudine, M. T., Orkin, S. H., Premawardhena, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103070 · Cited by 184

Predicting enhancer‐promoter interaction from genomic sequence with deep neural networks

Singh, S. K., Yang, Y., Póczos, B., & Ma, J. (2019) · Quantitative Biology · doi:10.1007/s40484-019-0154-0 · Cited by 176

The GATA factor revolution in hematology

Katsumura, K. R., Bresnick, E. H., & the GATA Factor Mechanisms Group (2017) · Blood · doi:10.1182/blood-2016-09-687871 · Cited by 184

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

Bauer, D. E., Kamran, S. C., & Orkin, S. H. (2012) · Blood · doi:10.1182/blood-2012-06-292078 · Cited by 177

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87885 · Cited by 167

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

Giardine, B. M., Borg, J., Higgs, D. R., Peterson, K. R., Philipsen, S., Maglott, D. R., Singleton, B. K., Anstee, D. J., Başak, A. N., Clark, B. E., et al. (2011) · Nature Genetics · doi:10.1038/ng.785 · Cited by 161

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells

Chang, K.-H., Smith, S. E., Sullivan, T., Chen, K., Zhou, Q., West, J. A., Liu, M., Liu, Y., Vieira, B. F., Sun, C., et al. (2017) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2016.12.009 · Cited by 155

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Grevet, J. D., Lan, X., Hamagami, N., Edwards, C. R., Sankaranarayanan, L., Ji, X., Bhardwaj, S. K., Face, C. J., Posocco, D. F., Abdulmalik, O. Y., et al. (2018) · Science · doi:10.1126/science.aao0932 · Cited by 151

Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

Xu, J., Shao, Z., Li, D., Xie, H., Kim, W., Huang, J., Taylor, J. E., Pinello, L., Glass, K., Jaffe, J. D., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.009 · Cited by 157

Molecular Basis and Genetic Modifiers of Thalassemia

Mettananda, S., & Higgs, D. R. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.11.003 · Cited by 130

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo

McGrath, K. E., Frame, J. M., Fromm, G. J., Koniski, A. D., Kingsley, P. D., Little, J. A., Bulger, M., & Palis, J. (2011) · Blood · doi:10.1182/blood-2010-12-325357 · Cited by 144

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.08.001 · Cited by 143

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

Huang, P., Keller, C. A., Giardine, B., Grevet, J. D., Davies, J. O. J., Hughes, J. R., Kurita, R., Nakamura, Y., Hardison, R. C., & Blobel, G. A. (2017) · Genes & Development · doi:10.1101/gad.303461.117 · Cited by 127

Dendritic cell fate is determined by BCL11A

Ippolito, G. C., Dekker, J. D., Wang, Y., Lee, B., Shaffer, A. L., Lin, J. X., Wall, J. K., Lee, B.-S., Staudt, L. M., Liu, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319228111 · Cited by 133

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin

Wienert, B., Funnell, A. P. W., Norton, L. J., Pearson, R. C. M., Wilkinson‐White, L. E., Lester, K. L., Vadolas, J., Porteus, M. H., Matthews, J. M., Quinlan, K. G. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms8085 · Cited by 125

Gene Therapy for β-Hemoglobinopathies

Cavazzana, M., Antoniani, C., & Miccio, A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.024 · Cited by 132

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction

Guda, S., Brendel, C., Renella, R., Du, P., Bauer, D. E., Canver, M. C., Grenier, J. K., Grimson, A., Kamran, S. C., Thornton, J. E., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.113 · Cited by 124

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype

Luc, S., Huang, J., McEldoon, J. L., Somuncular, E., Li, D., Rhodes, C., Mamoor, S., Hou, S., Xu, J., & Orkin, S. H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.064 · Cited by 126

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and numberPreprint

Sankaran, V. G., Ludwig, L. S., Sicińska, E., Xu, J., Bauer, D. E., Eng, J. C., Patterson, H. C., Metcalf, R. A., Natkunam, Y., Orkin, S. H., et al. (2012) · Genes & Development · doi:10.1101/gad.197020.112 · Cited by 126

MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

Lulli, V., Romania, P., Morsilli, O., Cianciulli, P., Gabbianelli, M., Testa, U., Giuliani, A., & Marziali, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060436 · Cited by 128

Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies

Wienert, B., Martyn, G. E., Funnell, A. P. W., Quinlan, K. G. R., & Crossley, M. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.09.004 · Cited by 115

Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells

Cui, S., Kolodziej, K. E., Obara, N., Amaral-Psarris, A., Demmers, J., Shi, L., Engel, J. D., Grosveld, F. G., Strouboulis, J., & Tanabe, O. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05310-11 · Cited by 112

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Basak, A., Munschauer, M., Lareau, C. A., Montbleau, K. E., Ulirsch, J. C., Hartigan, C. R., Schenone, M., Lian, J., Wang, Y., Huang, Y., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0568-7 · Cited by 105

Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

Sher, F., Hossain, M. A., Seruggia, D., Schoonenberg, V. A. C., Yao, Q., Cifani, P., Dassama, L. M. K., Cole, M. A., Ren, C., Vinjamur, D. S., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0453-4 · Cited by 113

Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies

Lettre, G., & Bauer, D. E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01341-0 · Cited by 104

Update on fetal hemoglobin gene regulation in hemoglobinopathies

Bauer, D. E., & Orkin, S. H. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283420fd0 · Cited by 111

Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Dulmovits, B. M., Appiah‐Kubi, A., Papoin, J., Hale, J., He, M., Al‐Abed, Y., Didier, S., Gould, M., Husain-Krautter, S., Singh, S. A., et al. (2015) · Blood · doi:10.1182/blood-2015-09-667923 · Cited by 102

Thalassemia Syndromes

Chapin, J. C., & Giardina, P. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00040-8 · Cited by 101

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer

Wilber, A. C., Hargrove, P. W., Kim, Y., Riberdy, J. M., Sankaran, V. G., Papanikolaou, E., Georgomanoli, M., Anagnou, N. P., Orkin, S. H., Nienhuis, A. W., et al. (2010) · Blood · doi:10.1182/blood-2010-08-300723 · Cited by 98

Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemiaPreprint

Ryba, T., Battaglia, D., Chang, B. H., Shirley, J. W., Buckley, Q., Pope, B. D., Devidas, M., Druker, B. J., & Gilbert, D. M. (2012) · Genome Research · doi:10.1101/gr.138511.112 · Cited by 99

Targeted Therapeutic Strategies for Fetal Hemoglobin Induction

Sankaran, V. G. (2011) · Hematology · doi:10.1182/asheducation-2011.1.459 · Cited by 102

Epigenetic regulation of fetal globin gene expression in adult erythroid cells

Ginder, G. D. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.002 · Cited by 97

A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease

Pule, G. D., Mowla, S., Novitzky, N., Wiysonge, C. S., & Wonkam, A. (2015) · Expert Review of Hematology · doi:10.1586/17474086.2015.1078235 · Cited by 103

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome

Magor, G. W., Tallack, M. R., Gillinder, K. R., Bell, C. C., McCallum, N., Williams, B., & Perkins, A. C. (2015) · Blood · doi:10.1182/blood-2014-08-590968 · Cited by 92

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells

Amaya, M., Desai, M., Gnanapragasam, M. N., Wang, S. Z., Zu Zhu, S., Williams, D. C., & Ginder, G. D. (2013) · Blood · doi:10.1182/blood-2012-11-466227 · Cited by 102

Sox6, jack of all trades: A versatile regulatory protein in vertebrate development

Hagiwara, N. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22639 · Cited by 88

Amplitude modulation of androgen signaling by c-MYCPreprint

Ni, M., Chen, Y., Fei, T., Li, D., Lim, E., Liu, X. S., & Brown, M. A. (2013) · Genes & Development · doi:10.1101/gad.209569.112 · Cited by 88

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

Liu, N., Xu, S., Yao, Q., Zhu, Q., Yan, K., Hsu, J. Y., Sakon, P., Pinello, L., Yuan, G., Bauer, D. E., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00798-y · Cited by 86

The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions

Lee, J., Krivega, I. V., Dale, R., & Dean, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.072 · Cited by 83

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis

Pimentel, H., Parra, M., Gee, S. L., Ghanem, D., An, X., Li, J., Mohandas, N., Pachter, L. S., & Conboy, J. G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1388 · Cited by 88

Genetic association studies in β-hemoglobinopathies

Thein, S. L. (2013) · Hematology · doi:10.1182/asheducation-2013.1.354 · Cited by 82

Analysis of chromatin-state plasticity identifies cell-type–specific regulators of H3K27me3 patterns

Pinello, L., Xu, J., Orkin, S. H., & Yuan, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322570111 · Cited by 76

BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases

Yin, J., Xie, X., Ye, Y., Wang, L., & Che, F. (2019) · Bioscience Reports · doi:10.1042/bsr20190604 · Cited by 73

SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities

Andrades, Á., Peinado, P., Álvarez-Pérez, J. C., Sanjuán‐Hidalgo, J., García, D. J., Arenas, A. M., Matia‐González, A. M., & Medina, P. P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01736-8 · Cited by 81

Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease

Khosravi, M. A., Abbasalipour, M., Concordet, J., Berg, J. V., Zeinali, S., Arashkia, A., Azadmanesh, K., Buch, T., & Karimipoor, M. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.04.042 · Cited by 71

Induction of adult levels of -globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

Trakarnsanga, K., Wilson, M. C., Lau, W. W. Y., Singleton, B. K., Parsons, S. F., Sakuntanaga, P., Kurita, R., Nakamura, Y., Anstee, D. J., & Frayne, J. (2014) · Haematologica · doi:10.3324/haematol.2014.110155 · Cited by 69

Three fingers on the switch

Tallack, M. R., & Perkins, A. C. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32835f59ba · Cited by 69

The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a

Cánovas, J., Berndt, F. A., Sepúlveda, H., Aguilar, R., Veloso, F. A., Montecino, M., Oliva, C., Maass, J. C., Sierralta, J., & Kukuljan, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0169-15.2015 · Cited by 63

Bcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo

Wu, X., Satpathy, A. T., Wumesh, K. C., Liu, P., Murphy, T. L., & MURPHY, K. M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064800 · Cited by 66

Sox6 enhances erythroid differentiation in human erythroid progenitors

Cantù, C., Ierardi, R., Alborelli, I., Fugazza, C., Cassinelli, L., Piconese, S., Bosè, F., Ottolenghi, S., Ferrari, G., & Ronchi, A. E. (2011) · Blood · doi:10.1182/blood-2010-04-282350 · Cited by 65

Fetal Globin Gene Repressors as Drug Targets for Molecular Therapies To Treat the β-Globinopathies

Suzuki, M., Yamamoto, M. P., & Engel, J. D. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00714-14 · Cited by 65

Regulation of the fetal hemoglobin silencing factor BCL11A

Basak, A., & Sankaran, V. G. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13024 · Cited by 68

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and diseasePreprint

Alendar, A., & Berns, A. J. M. (2021) · Genes & Development · doi:10.1101/gad.348897.121 · Cited by 69

Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells

Kiefer, C. M., Lee, J., Hou, C., Dale, R. K., Lee, Y. T., Meier, E. R., Miller, J. L., & Dean, A. (2011) · Blood · doi:10.1182/blood-2011-06-363101 · Cited by 59

Transcription regulation by distal enhancers

Stadhouders, R., van den Heuvel, A., Kolovos, P., Jorna, R., Leslie, K. D., Grosveld, F. G., & Soler, É. (2012) · Transcription · doi:10.4161/trns.20720 · Cited by 60

Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS

Trakarnsanga, K., Wilson, M. C., Griffiths, R. E., Toye, A. M., Carpenter, L., Heesom, K. J., Parsons, S. F., Anstee, D. J., & Frayne, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100874 · Cited by 56

Hydroxyurea down‐regulates BCL11A, KLF ‐ 1 and MYB through miRNA‐mediated actions to induce γ‐globin expression: implications for new therapeutic approaches of sickle cell disease

Pule, G. D., Mowla, S., Novitzky, N., & Wonkam, A. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0092-7 · Cited by 59

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases

Flores, C., Mojadidi, M., Phillips, J., Kuo, C. Y., Lai, S. Y., Lill, G. R., Cooper, A. R., Kaufman, M. L., Urbinati, F., Wang, X., et al. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.52 · Cited by 53

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease

Thein, S. L. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-7299-9_2 · Cited by 60

Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif

Jehle, K., Cato, L., Neeb, A., Muhle-Goll, C., Jung, N., Smith, E. W., Buzon, V., Carbó, L. R., Estébanez-Perpiñá, E., Schmitz, K., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534859 · Cited by 53

Thalassemias: from gene to therapy

Simone, G. D., Quattrocchi, A., Mancini, B., di Masi, A., Nervi, C., & Ascenzi, P. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101028 · Cited by 59

Reactivation of a developmentally silenced embryonic globin gene

King, A. J., Songdej, D., Downes, D. J., Beagrie, R. A., Liu, S., Buckley, M., Peng, H., Suciu, M., Oudelaar, A. M., Hanssen, L. L. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24402-3 · Cited by 57

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model

Rivers, A. E., Vaitkus, K., Ruiz, M. A., Ibañez, V., Jagadeeswaran, R., Kouznetsova, T., DeSimone, J., & Lavelle, D. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.04.005 · Cited by 52

Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6

An, C.-I., Dong, Y., & Hagiwara, N. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-59 · Cited by 60

A NuRD for all seasons

Reid, X. J., Low, J. K. K., & Mackay, J. P. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.06.002 · Cited by 57

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

Esteghamat, F., Gillemans, N., Bilić, I., van den Akker, E., Cantú, I., van Gent, T., Klingmüller, U., van Lom, K., Lindern, M. V., Grosveld, F. G., et al. (2013) · Blood · doi:10.1182/blood-2012-06-434530 · Cited by 52

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

Takase, S., Hiroyama, T., Shirai, F., Maemoto, Y., Nakata, A., Arata, M., Matsuoka, S., Sonoda, T., Niwa, H., Sato, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35404-0 · Cited by 50

A Feedback Loop Consisting of MicroRNA 23a/27a and the β-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression

Ma, Y., Wang, B., Jiang, F., Wang, D., Liu, H., Yan, Y., Dong, H., Wang, F., Gong, B., Zhu, Y., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00623-13 · Cited by 50

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, Y., Zhu, X., Ward, C. M., Starlard‐Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C. E., Kutlar, A., et al. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.11.002 · Cited by 51

CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease

Demirci, S., Leonard, A. K., Essawi, K., & Tisdale, J. F. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.09.010 · Cited by 56

Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system

Shariati, L., Khanahmad, H., Salehi, M., Hejazi, Z., Rahimmanesh, I., Tabatabaiefar, M. A., & Modarressi, M. H. (2016) · The Journal of Gene Medicine · doi:10.1002/jgm.2928 · Cited by 48

Strict in vivo specificity of the Bcl11a erythroid enhancer

Smith, E. C., Luc, S., Croney, D. M., Woodworth, M. B., Greig, L. C., Fujiwara, Y., Nguyen, M., Sher, F., Macklis, J. D., Bauer, D. E., et al. (2016) · Blood · doi:10.1182/blood-2016-08-736249 · Cited by 50

NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene

Zhu, X., Wang, Y., Pi, W., Liu, H., Wickrema, A., & Tuan, D. Y. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047175 · Cited by 47

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Funnell, A. P. W., Mak, K. S., Twine, N. A., Pelka, G. J., Norton, L. J., Radziewic, T., Power, M., Wilkins, M. R., Bell-Anderson, K. S., Fraser, S. T., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00074-13 · Cited by 47

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303976110 · Cited by 233

Transcriptional silencing of fetal hemoglobin by BCL11A

Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05574.x · Cited by 68

The roles of the transcription factor B-cell CLL/Lymphoma 11A (BCL11A) in erythroid cells

Yang, L. (2022) · UNSWorks (University of New South Wales, Sydney, Australia) · doi:10.26190/unsworks/3412

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

Huang, P., Peslak, S. A., Ren, R., Khandros, E., Qin, K., Keller, C. A., Giardine, B. M., Bell, H. W., Lan, X., Sharma, M., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01152-6 · Cited by 56

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.016 · Cited by 478