Cited by 361Hemoglobinopathies and Related DisordersGenomics and Chromatin DynamicsHemoglobin structure and function

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Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

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Xu, Jian, Sankaran, Vijay G., Ni, Min, Menne, Tobias F., Puram, Rishi V., Kim, Woojin, Orkin, Stuart H.·2010·Genes & Development

DOI 10.1101/gad.1897310PMC PMC2854393

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Abstract

The developmental switch from human fetal (γ) to adult (β) hemoglobin represents a clinically important example of developmental gene regulation. The transcription factor BCL11A is a central mediator of γ-globin silencing and hemoglobin switching. Here we determine chromatin occupancy of BCL11A at the human β-globin locus and other genomic regions in vivo by high-resolution chromatin immunoprecipitation (ChIP)–chip analysis. BCL11A binds the upstream locus control region (LCR), ɛ-globin, and the intergenic regions between γ-globin and δ-globin genes. A chromosome conformation capture (3C) assay shows that BCL11A reconfigures the β-globin cluster by modulating chromosomal loop formation. We also show that BCL11A and the HMG-box-containing transcription factor SOX6 interact physically and functionally during erythroid maturation. BCL11A and SOX6 co-occupy the human β-globin cluster along with GATA1, and cooperate in silencing γ-globin transcription in adult human erythroid progenitors. These findings collectively demonstrate that transcriptional silencing of γ-globin genes by BCL11A involves long-range interactions and cooperation with SOX6. Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the β-globin locus.

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The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
The ENCODE (ENCyclopedia Of DNA Elements) Project
(2004) · Science · doi:10.1126/science.1105136 · Cited by 2,390
Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908
The UCSC Genome Browser Database
Karolchik, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg129 · Cited by 1,890
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T., Luo, B., Grenier, J. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.040 · Cited by 1,804
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)
Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., & de Laat, W. (2006) · Nature Genetics · doi:10.1038/ng1896 · Cited by 1,386
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344
FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983
Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919
Self-citation
From head to toes: the multiple facets of Sox proteins
Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890
Gene regulation by proteins acting nearby and at a distance
Ptashne, M. (1986) · Nature · doi:10.1038/322697a0 · Cited by 860
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
Grosschedl, R., Giese, K., & Pagel, J. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90232-1 · Cited by 814
A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
Lefebvre, V., Li, P., & de Crombrugghe, B. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5718 · Cited by 811
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N. F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J. A., Umlauf, D., Dimitrova, D. S., et al. (2009) · Nature Genetics · doi:10.1038/ng.496 · Cited by 735
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711566105 · Cited by 672
Self-citation
The "beta-like-globin" gene domain in human erythroid cells.
Tuan, D., Solomon, W., Li, Q., & London, I. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6384 · Cited by 601
DNA polymorphisms at the BCL11A , HBS1L-MYB , and β- globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
Lettre, G., Sankaran, V. G., Bezerra, M., Araujo, A. S., Uda, M., Sanna, S., Cao, A., Schlessinger, D., Costa, F. F., Hirschhorn, J. N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804799105 · Cited by 577
Self-citation
The β-globin nuclear compartment in development and erythroid differentiation
Palstra, R.-J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F., & de Laat, W. (2003) · Nature Genetics · doi:10.1038/ng1244 · Cited by 559
Twenty Pairs of Sox
Schepers, G., Teasdale, R. D., & Koopman, P. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00223-x · Cited by 556
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2108 · Cited by 529
The UCSC Genome Browser Database: 2008 update
Karolchik, D., Kuhn, R. M., Baertsch, R., Barber, G. P., Clawson, H., Diekhans, M., Giardine, B. M., Harte, R., Hinrichs, A. S., Hsu, F., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm966 · Cited by 525
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490
Globin gene regulation and switching: Circa 1990
Orkin, S. H. (1990) · Cell · doi:10.1016/0092-8674(90)90133-y · Cited by 462
Self-citation
CEAS: cis-regulatory element annotation system
Shin, H., Liu, T., Manrai, A. K., & Liu, X. S. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp479 · Cited by 461
SRY, like HMG1, recognizes sharp angles in DNA.
Ferrari, S., Harley, V. R., Pontiggia, A., Goodfellow, P. N., Lovell-Badge, R. H., & Bianchi, M. E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05551.x · Cited by 440
Model-based analysis of tiling-arrays for ChIP-chip
Johnson, W. E., Li, W., Meyer, C. A., Gottardo, R., Carroll, J. S., Brown, M. A., & Liu, X. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601180103 · Cited by 428
Control of globin gene expression during development and erythroid differentiation
Stamatoyannopoulos, G. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.11.007 · Cited by 393
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system
Zhang, J., Socolovsky, M., Gross, A. W., & Lodish, H. F. (2003) · Blood · doi:10.1182/blood-2003-05-1479 · Cited by 386
Developmental and species-divergent globin switching are driven by BCL11A
Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature · doi:10.1038/nature08243 · Cited by 379
Self-citation
A developmentally stable chromatin structure in the human beta-globin gene cluster.
Forrester, W. C., Thompson, C. B., Elder, J. T., & Groudine, M. T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1359 · Cited by 376
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
Thein, S. L., Menzel, S., Xu, P., Best, S., Jiang, J., Close, J. P., Silver, N., Gerovassili, A., Chen, P., Yamaguchi, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611393104 · Cited by 313
Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis
Yu, M., Riva, L., Xie, H., Schindler, Y. L., Moran, T. B., Cheng, Y., Yu, D., Hardison, R. C., Weiss, M. J., Orkin, S. H., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.002 · Cited by 308
Self-citation
HMG1 and 2: architectural DNA-binding proteins
Thomas, J. O. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290395 · Cited by 257
Control of fetal hemoglobin: new insights emerging from genomics and clinical implications
Thein, S. L., Menzel, S., Lathrop, M., & Garner, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp401 · Cited by 250
Advances in the understanding of haemoglobin switching
Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08105.x · Cited by 225
Self-citation
β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region
Bender, M. A., Bulger, M., Close, J., & Groudine, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80433-5 · Cited by 224
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression
Cheng, Y., Wu, W., Ashok Kumar, S., Yu, D., Deng, W., Tripic, T., King, D. C., Chen, K.-B., Zhang, Y., Drautz, D., et al. (2009) · Genome Research · doi:10.1101/gr.098921.109 · Cited by 223
Regulation of human fetal hemoglobin: new players, new complexities
Bank, A. (2005) · Blood · doi:10.1182/blood-2005-05-2113 · Cited by 213
Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.Preprint
Strouboulis, J., Dillon, N., & Grosveld, F. G. (1992) · Genes & Development · doi:10.1101/gad.6.10.1857 · Cited by 210
CEAS: cis-regulatory element annotation system
Ji, X., Li, W., Song, J. S., Wei, L., & Liu, X. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl322 · Cited by 207
Discovering the genetics underlying foetal haemoglobin production in adults
Thein, S. L., & Menzel, S. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07650.x · Cited by 206
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cellsPreprint
Xu, J., Watts, J. A., Pope, S. D., Gadue, P. J., Kamps, M. P., Plath, K., Zaret, K. S., & Smale, S. T. (2009) · Genes & Development · doi:10.1101/gad.1861209 · Cited by 182
Self-citation
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter
Cismasiu, V. B., Adamo, K., Gecewicz, J., Duque, J., Lin, Q., & Avram, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208904 · Cited by 175
BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies
Sedgewick, A. E., Timofeev, N., Sebastiani, P., So, J. C. C., Ma, E. S. K., Chan, L. C., Fucharoen, G., Fucharoen, S., Barbosa, C. G., Vardarajan, B. N., et al. (2008) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2008.06.007 · Cited by 172
DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5
Connor, F., Cary, P. D., Read, C. M., Preston, N. S., Driscoll, P. C., Denny, P., Crane‐Robinson, C., & Ashworth, A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.16.3339 · Cited by 145
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins
Cantor, A. B., & Orkin, S. H. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.10.006 · Cited by 142
Self-citation
Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.
Gaensler, K. M. L., Kitamura, M., & Kan, Y. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11381 · Cited by 134
Chapter 4 β‐Globin Regulation and Long‐Range Interactions
Palstra, R., de Laat, W., & Grosveld, F. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00004-1 · Cited by 131
In Vitro Mass Production of Human Erythroid Cells from the Blood of Normal Donors and of Thalassemic Patients
Migliaccio, G., Pietro, R. D., di Giacomo, V., Baldassarre, A. D., Migliaccio, A. R., Maccioni, L., Galanello, R., & Papayannopoulou, T. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0502 · Cited by 126
Sox6 Directly Silences Epsilon Globin Expression in Definitive Erythropoiesis
Yi, Z., Cohen‐Barak, O., Hagiwara, N., Kingsley, P. D., Fuchs, D. A., Erickson, D. T., Epner, E. M., Palis, J., & Brilliant, M. H. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020014 · Cited by 119
Generation of mice harboring a Sox4 conditional null allele
Penzo‐Méndez, A., Dy, P., Bhattaram, P., & Lefèbvre, V. (2007) · genesis · doi:10.1002/dvg.20358 · Cited by 104
Mapping Chromatin Interactions by Chromosome Conformation Capture
Miele, A., Gheldof, N., Tabuchi, T. M., Dostie, J., & Dekker, J. (2006) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2111s74 · Cited by 99
Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells
Liu, H., Ippolito, G. C., Wall, J. K., Niu, T., Probst, L., Lee, B.-S., Pulford, K. A. F., Banham, A. H., Stockwin, L. H., Shaffer, A. L., et al. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-18 · Cited by 89
Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion
Navas, P. A., Peterson, K. R., Li, Q., Skarpidi, E., Rohde, A. D., Shaw, S. E., Clegg, C. H., Asano, H., & Stamatoyannopoulos, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4188 · Cited by 88
The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice
Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C. J., Chang, J., & Gaensler, K. M. L. (1997) · Blood · doi:10.1182/blood.v90.11.4602 · Cited by 79
SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter
Murakami, A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.16.3347 · Cited by 79
The N Termini of Friend of GATA (FOG) Proteins Define a Novel Transcriptional Repression Motif and a Superfamily of Transcriptional Repressors*
Lin, A.-C., Roche, A. E., Wilk, J., & Svensson, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411240200 · Cited by 75
Identification of ZBP-89 as a Novel GATA-1-Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development
Woo, A. J., Moran, T. B., Schindler, Y. L., Choe, S., Langer, N. B., Sullivan, M. R., Fujiwara, Y., Paw, B. H., & Cantor, A. B. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01945-07 · Cited by 64
GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol–linked proteins (paroxysmal nocturnal hemoglobinuria type II cells)
Jasinski, M., Keller, P., Fujiwara, Y., Orkin, S. H., & Bessler, M. (2001) · Blood · doi:10.1182/blood.v98.7.2248 · Cited by 59
Self-citation
Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming
Sripichai, O., Kiefer, C. M., Bhanu, N. V., Tanno, T., Noh, S.-J., Goh, S., Russell, J., Rognerud, C. L., Ou, C., Oneal, P. A., et al. (2009) · Blood · doi:10.1182/blood-2009-05-219386 · Cited by 59
HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology
Bagga, R., Michalowski, S. M., Sabnis, R. W., Griffith, J. D., & Emerson, B. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2541 · Cited by 50
The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carriers of β-thalassaemia
So, C.-C., Song, Y.-Q., Tsang, S. T. Y., Tang, L.-F., Chan, A. Y. Y., Ma, E. S., & Chan, L.-C. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.060335 · Cited by 45
LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs
Peterson, K. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.13.2079 · Cited by 36
Generation of mice harboring a Sox6 conditional null allele
Dumitriu, B., Dy, P., Smits, P. J., & Lefebvre, V. (2006) · genesis · doi:10.1002/dvg.20210 · Cited by 35
The HMG Domain Protein SSRP1/PREIIBF Is Involved in Activation of the Human Embryonic β-Like Globin Gene
Dyer, M. A., Hayes, P. J., & Baron, M. H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2617 · Cited by 32
Synergistic and Additive Properties of the Beta-Globin Locus Control Region (LCR) Revealed by 5′HS3 Deletion Mutations: Implication for LCR Chromatin Architecture
Fang, X., Sun, J., Xiang, P., Yu, M., Navas, P. A., Peterson, K. R., Stamatoyannopoulos, G., & Li, Q. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7033-7041.2005 · Cited by 27
Stem cell transplantation demonstrates that Sox6 represses εy globin expression in definitive erythropoiesis of adult mice
Cohen‐Barak, O., Erickson, D. T., Badowski, M., Fuchs, D. A., Klassen, C. L., Harris, D. T., & Brilliant, M. H. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2006.11.009 · Cited by 22
A DNA-Bending Protein Interacts with an Essential Upstream Regulatory Element of the Human Embryonic β-Like Globin Gene
Dyer, M. A., Naidoo, R., Hayes, P. J., Larson, C. J., Verdine, G. L., & Baron, M. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.829 · Cited by 11
The role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression
Drew, L. R. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.14.2823 · Cited by 9
Transgenic mice containing a 248-kilobase human beta locus yeast artificial chromosome display proper developmental control of human globin genes.
Peterson, K. R., Clegg, C. H., Huxley, C. M., Josephson, B. M., Haugen, H. S., Furukawa, T., & Stamatoyannopoulos, G. (1993) · PubMed · Cited by 3

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Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science · doi:10.1126/science.1242088 · Cited by 653
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Authors: Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H.
Affiliations: Boston Children's Hospital (US)
Harvard University (US)
Harvard–MIT Division of Health Sciences and Technology (US)
ORCID: Xu, Jian
Sankaran, Vijay G.
Ni, Min
Menne, Tobias F.
Kim, Woojin
Orkin, Stuart H.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2010-04-15
Volume: 24
Issue: 8
Pages: 783-798
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1897310
PMC: PMC2854393
OpenAlex: W2134881764
Semantic Scholar: 097ee5589990708503598c372d66d87bf5262280
Cited by: 361
References: 71
Citations by year: 2026: 12 · 2025: 19 · 2024: 19 · 2023: 15 · 2022: 23 · 2021: 21 · 2020: 20 · 2019: 17 · 2018: 21 · 2017: 31 · 2016: 30 · 2015: 25 · 2014: 26 · 2013: 23 · 2012: 22
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Kay Kendall Leukaemia Fund
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL032259, T32HL116324)
National Cancer Institute (K12CA087723)
National Institute of General Medical Sciences (T32GM007753)
National Institute of Diabetes and Digestive and Kidney Diseases
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: BCL11A, SOX6, beta-globin locus, hemoglobin switching, long-range chromatin interactions, chromatin looping, locus control region, erythroid maturation, GATA-1, erythroid progenitor cells, developmental gene regulation, chromatin occupancy
MeSH terms: Adult, Animals, Carrier Proteins, Cell Line, Erythropoiesis, Histones, Humans, Nuclear Proteins, Protein Binding, Repressor Proteins, Gene Expression Regulation, Developmental, Gene Silencing, Protein Transport, Erythroid Cells, GATA1 Transcription Factor, Mice, gamma-Globins, SOXD Transcription Factors

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Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

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