The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.
Open accessAbstract
The muE3 motif within the immunoglobulin heavy-chain enhancer is required for full enhancer activity and is known to bind one, or perhaps a family, of related ubiquitous nuclear proteins. Here, we present the isolation of a cDNA that encodes an apparently novel microE3-binding protein designated TFE3. The major open reading frame of the cDNA predicts a protein of 59 kD, with a leucine zipper situated adjacent to an myc-related motif that has been proposed to assume a helix-loop-helix structure. Both of these motifs have been shown (for other proteins) to facilitate protein-protein interactions and DNA binding. Expression of the cDNA in 3T3 cells stimulates transcription from an artificial promoter consisting of four muE3 sites linked to a TATA box and also augments transcription of a reporter gene when it is linked to multiple copies of a particular heavy-chain enhancer subfragment but not when it is linked to the intact enhancer. Using GAL4 fusion proteins, we mapped a strong transcription activation domain within TFE3 that is distinct from the leucine zipper and helix-loop-helix motifs and includes a potential negative amphipathic helix. Like the other muE3-binding proteins detected in nuclear extracts, in vitro-synthesized TFE3 also binds to the USF/MLTF site found in the adenovirus major late promoter.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a001 · Cited by 2,172
Cited by
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
Compilation of vertebrate-encoded transcription factors
Faisst, S., & Meyer, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.3 · Cited by 914
Regulation of metallothionein gene expression by oxidative stress and metal ions
Andrews, G. K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00301-9 · Cited by 834
Melanocytes and the Microphthalmia Transcription Factor Network
Steingrímsson, E., Copeland, N. G., & Jenkins, N. A. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092717 · Cited by 771
Hemesath, T. J., Steingrímsson, E., McGill, G., Hansen, M. J., Vaught, J., Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., Jenkins, N. A., & Fisher, D. E. (1994) · Genes & Development · doi:10.1101/gad.8.22.2770 · Cited by 673
Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region
Prendergast, G. C., & Ziff, E. B. (1991) · Science · doi:10.1126/science.1987636 · Cited by 579
Oncogenic activity of the c-Myc protein requires dimerization with Max
Amati, B., Brooks, M. W., Levy, N., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · Cell · doi:10.1016/0092-8674(93)90663-b · Cited by 560
Prendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558
Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif
Henthorn, P., Kiledjian, M., & Kadesch, T. (1990) · Science · doi:10.1126/science.2105528 · Cited by 462
Self-citationLiao, X., & Butow, R. A. (1993) · Cell · doi:10.1016/0092-8674(93)90050-z · Cited by 419
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
Facchini, L. M., & Penn, L. Z. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.633 · Cited by 377
Seipel, K., Georgiev, O., & Schaffner, W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05603.x · Cited by 349
Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein that Interacts with c-Fos
Blanar, M. A., & Rutter, W. J. (1992) · Science · doi:10.1126/science.1589769 · Cited by 334
Kim, J. B., Spotts, G. D., Halvorsen, Y.-D., Shih, H.-M., Ellenberger, T., Towle, H. C., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2582 · Cited by 324
Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells
Sirito, M., Lin, Q., Maity, T., & Sawadogo, M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.3.427 · Cited by 320
Sartorelli, V, Webster, K. A., & Kedes, L. (1990) · Genes & Development · doi:10.1101/gad.4.10.1811 · Cited by 314
c-Myc target gene specificity is determined by a post-DNAbinding mechanism
Boyd, K. E., Wells, J., Gutman, J., Bartley, S. M., & Farnham, P. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13887 · Cited by 276
Transcriptional Regulation of Autophagy: Mechanisms and Diseases
Di Malta, C., Cinque, L., & Settembre, C. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00114 · Cited by 255
Lee, Y.-N., Nechushtan, H., Figov, N., & Razin, E. (2004) · Immunity · doi:10.1016/s1074-7613(04)00020-2 · Cited by 184
Factors and forces controlling V(D) J recombination
Hesslein, D. G. T., & Schatz, D. G. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)78004-2 · Cited by 183
Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. C., & Hume, D. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1559 · Cited by 116
Feinman, R., Qiu, W. Q., Pearse, R. N., Nikolajczyk, B. S., Sen, R., Sheffery, M., & Ravetch, J. V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06696.x · Cited by 88
Himmelmann, A., Riva, A., Wilson, G. L., Lucas, B. P., Thevenin, C., & Kehrl, J. H. (1997) · Blood · doi:10.1182/blood.v90.10.3984 · Cited by 68
Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec
Lister, J. A., Lane, B. M., Nguyen, A., & Lunney, K. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22743 · Cited by 61
Eisenbeis, C. F., Singh, H., & Storb, U. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6452-6461.1993 · Cited by 38
Metadata
- Authors
- Beckmann, H., Su, L. K., & Kadesch, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-02
- Volume
- 4
- Issue
- 2
- Pages
- 167-179
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2053879589
- Cited by
- 457
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
