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The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes

Himmelmann, Andreas, Riva, Agostino, Wilson, Gaye Lynn, Lucas, Brian P., Thevenin, Claire, Kehrl, John H.·1997·Blood
DOI 10.1182/blood.v90.10.3984
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Abstract

CD20 is a B-lineage–specific gene expressed at the pre–B-cell stage of B-cell development that disappears on differentiation to plasma cells. As such, it serves as an excellent paradigm for the study of lineage and developmental stage-specific gene expression. Using in vivo footprinting we identified two sites in the promoter at −45 and −160 that were occupied only in CD20+ B cells. The −45 site is an E box that binds basic helix-loop-helix-zipper proteins whereas the −160 site is a composite PU.1 and Pip binding site. Transfection studies with reporter constructs and various expression vectors verified the importance of these sites. The composite PU.1 and Pip site likely accounts for both lineage and stage-specific expression of CD20 whereas the CD20 E box binding proteins enhance overall promoter activity and may link the promoter to a distant enhancer.

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Research works printed but not linked: 36

  1. Blackwell, 1989, Mechanism and developmental program of immunoglobulin gene rearrangement in mammals., Annu Rev Genet, 23, 605, 10.1146/annurev.ge.23.120189.003133 · DOI
  2. Kehrl, 1994, Molecular mechanisms regulating CD19, CD20 and CD22 gene expression., Immunol Today, 15, 432, 10.1016/0167-5699(94)90273-9 · DOI
  3. Hagman, 1994, Regulation of gene expression at early stages of B cell differentiation., Curr Opin Immunol, 6, 222, 10.1016/0952-7915(94)90095-7 · DOI
  4. Singh, 1994, Genetic analysis of transcription factors implicated in B lymphocyte development., Immunol Res, 13, 280, 10.1007/BF02935619 · DOI
  5. Ernst, 1995, Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain enhancer., Immunity, 2, 427, 10.1016/1074-7613(95)90024-1 · DOI
  6. Urbanek, 1994, Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP., Cell, 79, 901, 10.1016/0092-8674(94)90079-5 · DOI · Paper page
  7. Lin, 1995, Failure of B-cell differentiation in mice lacking the transcription factor EBF., Nature, 376, 263, 10.1038/376263a0 · DOI · Paper page
  8. Zhuang, 1994, The helix-loop-helix gene E2A is required for B cell formation., Cell, 79, 875, 10.1016/0092-8674(94)90076-0 · DOI · Paper page
  9. Scott, 1994, Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages., Science, 265, 1573, 10.1126/science.8079170 · DOI · Paper page
  10. Georgopoulos, 1994, The Ikaros gene is required for the development of all lymphoid lineages., Cell, 79, 143, 10.1016/0092-8674(94)90407-3 · DOI · Paper page
  11. Nadler, 1984, B cell origin of non-T cell acute lymphoblastic leukemia., J Clin Invest, 74, 332, 10.1172/JCI111428 · DOI
  12. Tedder, 1994, CD20: A regulator of cell-cycle progression of B lymphocytes., Immunol Today, 15, 450, 10.1016/0167-5699(94)90276-3 · DOI
  13. Rickmann, 1991, Analysis of Cis-acting elements present in the CD20/B1 antigen promoter., J Immunol, 147, 3994, 10.4049/jimmunol.147.11.3994 · DOI
  14. Tedder, 1989, Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)., J Immunol, 142, 2560, 10.4049/jimmunol.142.7.2560 · DOI
  15. Thevenin, 1993, Cell type- and stage-specific expression of the CD2/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter., J Biol Chem, 268, 5949, 10.1016/S0021-9258(18)53411-6 · DOI
  16. Corcoran, 1993, Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival., Genes Dev, 7, 570, 10.1101/gad.7.4.570 · DOI
  17. Dignam, 1983, Eukaryotic gene transcription with purified components., Method Enzymol, 101, 582, 10.1016/0076-6879(83)01039-3 · DOI
  18. Kadesch, 1992, Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription., Immunol Today, 13, 31, 10.1016/0167-5699(92)90201-H · DOI
  19. Petterson, 1987, A purine-rich DNA sequence motif present in SV 40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells., Genes Dev, 1, 962, 10.1101/gad.1.9.962 · DOI
  20. Klemsz, 1990, The macrophage and B cell-specific transcription factor PU.1 is related to the Ets oncogene., Cell, 61, 113, 10.1016/0092-8674(90)90219-5 · DOI · Paper page
  21. Nagulapalli, 1995, Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)., J Immunol, 155, 4330, 10.4049/jimmunol.155.9.4330 · DOI · Paper page
  22. Driggers, 1990, An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes., Proc Natl Acad Sci, 87, 3743, 10.1073/pnas.87.10.3743 · DOI · Paper page
  23. Pettersson, 1995, The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines., Blood, 86, 2747, 10.1182/blood.V86.7.2747.2747 · DOI
  24. Nelsen, 1993, Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins., Science, 261, 82, 10.1126/science.8316859 · DOI · Paper page
  25. Crepieux, 1994, The Ets family of proteins: Weak modulators of gene transcription in quest for transcriptional partners., Crit Rev Oncol, 5, 615
  26. Church, 1985, Cell-type-specific contacts to immunoglobulin enhancers in nuclei., Nature, 313, 798, 10.1038/313798a0 · DOI
  27. Ephrussi, 1985, B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo., Science, 227, 134, 10.1126/science.3917574 · DOI
  28. Beckmann, 1990, TFE3: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif., Genes Dev, 4, 167, 10.1101/gad.4.2.167 · DOI
  29. Roman, 1992, mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization., Mol Cell Biol, 12, 817, 10.1128/MCB.12.2.817 · DOI
  30. Lenardo, 1987, Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility., Science, 236, 1573, 10.1126/science.3109035 · DOI
  31. Gregor, 1990, The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer., Genes Dev, 4, 1730, 10.1101/gad.4.10.1730 · DOI
  32. Carr, 1990, A helix-loop-helix protein related to the immunoglobulin E box-binding proteins., Mol Cell Biol, 10, 4384, 10.1128/MCB.10.8.4384 · DOI
  33. Chodosh, 1987, The adenovirus major late transcription factor activates the rat-γ fibrinogoen promoter., Science, 238, 684, 10.1126/science.3672119 · DOI
  34. Cogswell, 1995, Upstream stimulatory factor regulates expression of the cell cycle-dependent cyclin B1 gene promoter., Mol Cell Biol, 15, 2782, 10.1128/MCB.15.5.2782 · DOI
  35. Reisman, 1993, The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene., Nucleic Acids Res, 21, 345, 10.1093/nar/21.2.345 · DOI
  36. Artandi, 1994, The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction., Mol Cell Biol, 14, 7704, 10.1128/MCB.14.12.7704 · DOI

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Metadata

Authors
Himmelmann, A., Riva, A., Wilson, G. L., Lucas, B. P., Thevenin, C., & Kehrl, J. H.
Venue
Blood
Publisher
American Society of Hematology
Published
1997-11-15
Volume
90
Issue
10
Pages
3984-3995
ISSN
  • 1528-0020
  • 0006-4971
DOI
10.1182/blood.v90.10.3984
Cited by
68
References
14
Language
en

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