PreprintCited by 213Memory and Neural MechanismsHistone Deacetylase Inhibitors ResearchNeuroscience and Neuropharmacology Research

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HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

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Haettig, Jakob, Stefanko, Daniel P., Multani, Monica L., Figueroa, Dario X., McQuown, Susan C., Wood, Marcelo A.·2011·Learning & Memory

DOI 10.1101/lm.1986911PMC PMC3032579

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Abstract

Transcription of genes required for long-term memory not only involves transcription factors, but also enzymatic protein complexes that modify chromatin structure. Chromatin-modifying enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory. Several studies have shown that CBP and histone acetylation are necessary for hippocampus-dependent long-term memory and hippocampal long-term potentiation (LTP). Importantly, every genetically modified Cbp mutant mouse exhibits long-term memory impairments in object recognition. However, the role of the hippocampus in object recognition is controversial. To better understand how chromatin-modifying enzymes modulate long-term memory for object recognition, we first examined the role of the hippocampus in retrieval of long-term memory for object recognition or object location. Muscimol inactivation of the dorsal hippocampus prior to retrieval had no effect on long-term memory for object recognition, but completely blocked long-term memory for object location. This was consistent with experiments showing that muscimol inactivation of the hippocampus had no effect on long-term memory for the object itself, supporting the idea that the hippocampus encodes spatial information about an object (such as location or context), whereas cortical areas (such as the perirhinal or insular cortex) encode information about the object itself. Using location-dependent object recognition tasks that engage the hippocampus, we demonstrate that CBP is essential for the modulation of long-term memory via HDAC inhibition. Together, these results indicate that HDAC inhibition modulates memory in the hippocampus via CBP and that different brain regions utilize different chromatin-modifying enzymes to regulate learning and memory.

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Authors: Haettig, J., Stefanko, D. P., Multani, M. L., Figueroa, D. X., McQuown, S. C., & Wood, M. A.
Affiliations: University of California, Irvine (US)
ORCID: Stefanko, Daniel P.
Wood, Marcelo A.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2011-01-11
Volume: 18
Issue: 2
Pages: 71-79
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.1986911
PMC: PMC3032579
OpenAlex: W2159726740
Cited by: 211
References: 38
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 20 · 2018: 12 · 2017: 18 · 2016: 21 · 2015: 9 · 2014: 21 · 2013: 25 · 2012: 13
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Whitehall Foundation
National Institute of Mental Health (R01MH081004)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: histone deacetylase inhibition, CBP, CREB-binding protein, hippocampal-dependent memory, object location memory, object recognition memory, long-term memory, chromatin modification, histone acetylation, muscimol inactivation, spatial memory, memory retrieval, hippocampal long-term potentiation
MeSH terms: Animals, Hippocampus, Histone Deacetylases, Immunohistochemistry, Learning, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Muscimol, CREB-Binding Protein, Mice, Gene Knock-In Techniques, Histone Deacetylase Inhibitors, Memory, Long-Term, GABA-A Receptor Agonists

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HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

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