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Examining Object Location and Object Recognition Memory in Mice
Abstract
This unit is designed to provide sufficient instruction for the setup and execution of tests for object location and object recognition in adult mice. This task is ideally suited for the study of a variety of mouse models that examine disease mechanisms and novel therapeutic targets. By altering several key parameters, the experimenter can investigate short‐term or long‐term memory and look for either memory impairments or enhancements. Object location and object recognition memory tasks rely on a rodent's innate preference for novelty, and can be conducted sequentially in the same cohort of animals. These two tasks avoid the inherent stress induced with other common measures of rodent memory such as fear conditioning and the Morris water maze. This protocol covers detailed instructions on conducting both tasks, as well as key points concerning data collection, analysis, and interpretation. Curr. Protoc. Neurosci . 69:8.31.1‐8.31.17. © 2014 by John Wiley & Sons, Inc.
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Mice that accumulated less than 10 s of total exploration time across both objects during the training session were excluded from subsequent analyses.
“Mice that accumulated less than 10 s of total exploration time across both objects during the training session were excluded from subsequent analyses53.”
From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [53]
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Metadata
- Authors
- Vogel‐Ciernia, A., & Wood, M. A.
- Affiliations
- Department of Neurobiology and Behavior, University of California Irvine, Irvine California
- Venue
- Current Protocols in Neuroscience
- Publisher
- Wiley
- Published
- 2014-10
- Volume
- 69
- Issue
- 1
- ISSN
- 1934-8584
- 1934-8576
- PMC
- PMC4219523
- Cited by
- 342
- References
- 3
- Language
- en
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