Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

Moxon, K.A.; Leiser, S.; Gerhardt, G.A.; Barbee, K.A.; Chapin, J.K.

doi:10.1109/tbme.2003.821037

Cited by 129Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignNeural dynamics and brain function

Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

Moxon, K.A., Leiser, S., Gerhardt, G.A., Barbee, K.A., Chapin, J.K.·2004·IEEE Transactions on Biomedical Engineering

DOI 10.1109/tbme.2003.821037

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Abstract

A method is described for the manufacture of a microelectrode array for chronic, multichannel, single neuron recording. The ceramic-based, multisite electrode array has four recording sites patterned onto a ceramic shaft the size of a single typical microwire electrode. The sites and connecting wires are applied to the ceramic substrate using a reverse photolithographic procedure. Recording sites (22 x 80 microm) are separated by 200 microm along the shaft. A layer of alumina insulation is applied over the whole array (exclusive of recording sites) by ion-beam assisted deposition. These arrays were capable of recording single neuron activity from each of their recording sites for at least three weeks during chronic implantation in the somatosensory cortex of rats, and several sites had recordings that lasted for more than 8 weeks. The vertical arrangement of the recording sites on these electrodes is ideal for simultaneously recording across the different layers of brain areas such as the cerebral cortex and hippocampus in chronic preparations.

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2D neural probes are limited to recording signals from only planar brain regions.
“However, neural tissues are normally three-dimensional (3D) structures, and 2D neural probes are limited to recording signals from only planar brain regions4,5.”
From A flexible three-dimensional electrode mesh: An enabling technology for wireless brain–computer interface prostheses (2016) · cites this paper as [4]

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Authors: Moxon, K. A., Leiser, S., Gerhardt, G. A., Barbee, K. A., & Chapin, J. K.
Affiliations: Drexel University (US)
Hahnemann University Hospital (US)
University of Kentucky (US)
State University of New York (US)
ORCID: Moxon, K.A.
Leiser, S.
Gerhardt, G.A.
Venue: IEEE Transactions on Biomedical Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 2004-04
Volume: 51
Issue: 4
Pages: 647-656
ISSN: 0018-9294 (ISSN-L)
DOI: 10.1109/tbme.2003.821037
OpenAlex: W2121376289
Semantic Scholar: 68308b39d256517d8eed044c989c5a92e6218d05
Cited by: 129
References: 47
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 4
FWCI: 3.87
Type: journal article
Language: en
Open access: closed
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Transactions on Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01ns026722-13, 5r21da014944-02)
National Institute on Drug Abuse (DA14944)
National Institute of Neurological Disorders and Stroke (1-R01-NS26722)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: single-unit recording, chronic implantation, ion beam assisted deposition, somatosensory cortex, multichannel recording, neural recording electrodes
MeSH terms: Action Potentials, Animals, Ceramics, Electrodes, Implanted, Equipment Design, Male, Microelectrodes, Nerve Net, Neurons, Sensitivity and Specificity, Somatosensory Cortex, Reproducibility of Results, Monitoring, Ambulatory, Equipment Failure Analysis, Rats, Long-Evans, Rats

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Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

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