A system for neural recording and closed-loop intracortical microstimulation in awake rodents.
Abstract
There is growing interest in intracortical microstimulation as a means of providing sensory input in neuroprosthetic systems. We believe that precisely controlling the timing and parameters of stimulation in closed loop can significantly improve the efficacy of this technique. Here, we present a system for closed-loop microstimulation in awake rodents chronically implanted with multielectrode arrays. The system interfaces with existing commercial recording and stimulating hardware. Using custom-made hardware, we can stimulate and record from electrodes on the same implanted array and significantly reduce the stimulation artifact. Stimulation sequences can either be preprogrammed or triggered by neural or behavioral events. Specifically, this system can provide feedback stimulation in response to action potentials or features in the local field potential recorded on any of the electrodes within 15 ms. It can also trigger stimulation based on behavioral events, such as real-time tracking of rat whiskers captured with high-speed video. We believe that this system, which can be recreated easily, will help to significantly refine the technique of intracortical microstimulation and advance the field of neuroprostheses.
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The blanking technique and digital signal processing have been used to cancel the artifact.
“The blanking technique and digital signal processing (Erez et al., 2010) have been used to cancel the artifact (Olsson et al., 2005; Venkatraman et al., 2009; Kent and Grill, 2011; Myers et al., 2011; Zoladz et al., 2012; Wei-Ming et al., 2013; Yi et al., 2013; Bozorgzadeh et al., 2014; Elyahoodayan et al., 2019).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Venkatraman et al., 2009
Such a stimulation artifact can be observed in most closed-loop recording and stimulation circuits.
“Such a stimulation artifact can be observed in most of the closed-loop recording and stimulation circuits (Yoshida and Horch, 1996; Blum et al., 2007; Venkatraman et al., 2009; Mc Laughlin et al., 2012; Ng et al., 2012; Xu et al., 2012).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Venkatraman et al., 2009
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- Authors
- Venkatraman, S., Elkabany, K., Long, J. D., Yao, Y., & Carmena, J. M.
- Affiliations
- University of California, Berkeley (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2009-01
- Volume
- 56
- Issue
- 1
- Pages
- 15-22
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2109583917
- Cited by
- 96
- References
- 42
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 6
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California Berkeley
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- intracortical microstimulation, closed-loop stimulation, neural recording, microelectrode arrays, neuroprosthetics, stimulation artifacts, local field potentials, action potential
- MeSH terms
- Algorithms, Animals, Behavior, Animal, Electric Stimulation, Electrodes, Implanted, Feedback, Microelectrodes, Models, Neurological, Neurons, Prosthesis Design, Signal Processing, Computer-Assisted, Somatosensory Cortex, Vibrissae, Artifacts, Rats
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