Immunosenescence is associated with human cytomegalovirus and shortened telomeres in type I bipolar disorder
Abstract
OBJECTIVE: Bipolar disorder (BD) has been associated with persistent low-grade inflammation and premature cell senescence, as shown by reduced telomere length (TL). The human cytomegalovirus (CMV) has increasingly been implicated in accelerated immunosenescence in aging studies. Here, we compared CMV serology and its relationships with cell senescence markers, including TL and lymphocyte subsets, in patients with type I BD and healthy controls. METHODS: Twenty-two euthymic female patients with BD type I and 17 age-matched healthy controls were selected for the study. A sample of blood was collected and mononuclear cells and DNA were isolated and TL measured. CMV immunoglobulin M (IgM) and IgG titers were measured using chemiluminescent assays. Lymphocyte subsets [T, natural killer (NK) and NKT] were phenotyped by flow cytometry. RESULTS: Individuals with BD had shorter TLs but higher CMV IgG levels than controls (both p < 0.01). CMV IgG level was inversely correlated with TL. None of the subjects showed IgM reactivity for CMV, excluding acute viral infection. CMV IgG level was associated with expansion of senescent CD8+CD28- T cells and NK cells, which are involved in viral control. CONCLUSIONS: These data support the hypothesis of accelerated aging in BD, as shown by shortened telomeres, higher seropositivity for CMV, and expansion of senescent T cells.
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In Rizzo et al., IgG antibodies to cytomegalovirus were significantly elevated in the BD group and these levels were inversely correlated with LTL.
“In that study, IgG antibodies to cytomegalovirus (CMV) were significantly elevated in the BD group, and these levels were inversely correlated with LTL, suggesting that exposure to this virus might have played a role in immunosenescence and telomere shortening in the BD group.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Rizzo et al., 2013
In Rizzo et al., years of bipolar illness (corrected for age) were not significantly correlated with LTL.
“Years of bipolar illness (corrected for age) were not significantly correlated with LTL.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Rizzo et al., 2013
Rizzo et al. (2013) found significantly shorter PBMC TL in euthymic women with BD type I.
“Rizzo et al. (2013) found significantly shorter PBMC TL in euthymic women with BD type I (men were not studied).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Rizzo et al. (2013)
Cites
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Acuto, O., & Michel, F. (2003) · Nature Reviews Immunology · doi:10.1038/nri1248 · Cited by 775 · see citing works
Sustained attention deficit in bipolar disorder
Clark, L., Iversen, S. D., & Goodwin, G. M. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.4.313 · Cited by 539 · see citing works
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516 · see citing works
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works
Iwamoto, K., Bundo, M., & Kato, T. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi022 · Cited by 496 · see citing works
Allostatic load in bipolar disorder: Implications for pathophysiology and treatment
Kapczinski, F. P., Vieta, E., Andreazza, A. C., Frey, B. N., Gomes, F. A., Tramontina, J., Kauer‐Sant’Anna, M., Grassi‐Oliveira, R., & Post, R. M. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.005 · Cited by 479 · see citing works
Self-citationEffros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457 · see citing works
CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 432 · see citing works
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430 · see citing works
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Brietzke, E., Stertz, L., Fernandes, B. S., Kauer-Sant’Anna, M., Mascarenhas, M., Escosteguy Vargas, A., Chies, J. A., & Kapczinski, F. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.001 · Cited by 423 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402 · see citing works
Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler‐Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck‐Loebenstein, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3675-3683.2005 · Cited by 356 · see citing works
Tyrka, A. R., Price, L. H., Kao, H.-T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.014 · Cited by 342 · see citing works
Immune suppression and immune activation in depression
Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Are some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 327 · see citing works
Serum S100B and antioxidant enzymes in bipolar patients
Andreazza, A. C., Cassini, C., Rosa, A. R., Leite, M. C., de Almeida, L. M. V., Nardin, P., da Cunha, A. B., Ceresér, K. M. M., Santin, A. M. P., Gottfried, C., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.013 · Cited by 307 · see citing works
Depression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298 · see citing works
Wang, G. C., Kao, W. H. L., Murakami, P. N., Xue, Q., Chiou, R. B., Detrick, B., McDyer, J. F., Semba, R. D., Casolaro, V., Walston, J. D., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq062 · Cited by 266 · see citing works
Ouyang, Q., Wagner, W. M., Wikby, A., Walter, S., Aubert, G., Dodi, A. I., Travers, P. J., & Pawelec, G. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024580531705 · Cited by 239 · see citing works
Sun, X., Wang, J., Tseng, M., & Young, L. T. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0623 · Cited by 238 · see citing works
Eren, İ., Nazıroğlu, M., & Demirdaş, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9289-x · Cited by 234 · see citing works
Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication
Zhu, H., Cong, J.-P., Yu, D., Bresnahan, W. A., & Shenk, T. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052713799 · Cited by 228 · see citing works
Shao, L., Young, L. T., & Wang, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.052 · Cited by 218 · see citing works
Yurochko, A. D., Hwang, E. S., Rasmussen, L., Keay, S. K., Pereira, L., & Huang, E. S. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5051-5059.1997 · Cited by 207 · see citing works
Role of CMV in immune senescence.
Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201 · see citing works
CD28 Expression in T Cell Aging and Human Longevity
Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00132-0 · Cited by 194 · see citing works
Wikgren, M., Maripuu, M., Karlsson, T., Nordfjäll, K., Bergdahl, J., Hultdin, J., Del‐Favero, J., Roos, G., Nilsson, L., Adolfsson, R., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.015 · Cited by 173 · see citing works
The activation of monocyte and T cell networks in patients with bipolar disorder
Drexhage, R. C., Hoogenboezem, T., Versnel, M. A., Berghout, A., Nolen, W. A., & Drexhage, H. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.013 · Cited by 172 · see citing works
Hartmann, N., Boehner, M., Groenen, F., & Kalb, R. (2010) · Depression and Anxiety · doi:10.1002/da.20749 · Cited by 156 · see citing works
Breunis, M. N., Kupka, R., Nolen, W. A., Suppes, T. M., Denicoff, K. D., Leverich, G. S., Post, R. M., & Drexhage, H. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01452-x · Cited by 149 · see citing works
Effros, R. B., Cai, Z., & Linton, P. (2003) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v23.i12.30 · Cited by 143 · see citing works
Elvsåshagen, T., Vera, E., Bøen, E., Bratlie, J., Andreassen, O. A., Josefsen, D., Malt, U. F., Blasco, M. A., & Boye, B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.006 · Cited by 133 · see citing works
do Prado, C. H., Rizzo, L. B., Wieck, A., Lopes, R. P., Teixeira, A. L., Grassi‐Oliveira, R., & Bauer, M. E. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.005 · Cited by 127 · see citing works
Self-citationBarbosa, I. G., Rocha, N. P., Huguet, R. B., Ferreira, R. A., Salgado, J. V., de Carvalho, L. A., Pariante, C. M., & Teixeira, A. L. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.034 · Cited by 121 · see citing works
Self-citationTedla, Y., Shibre, T., Ali, O., Tadele, G., Woldeamanuel, Y., Asrat, D., Aseffa, A., Mihret, W., Abebe, M., Alem, A., et al. (2011) · PubMed · Cited by 97 · see citing works
López‐Botet, M., Angulo, A., & Gumá, M. (2004) · Tissue Antigens · doi:10.1111/j.1399-0039.2004.00210.x · Cited by 97 · see citing works
Immunological Differences in Women Compared with Men: Overview and Contributing Factors
Ghazeeri, G. S., Abdullah, L., & Abbas, O. M. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.01052.x · Cited by 92 · see citing works
Taylor, G. H. (2003) · PubMed · Cited by 87 · see citing works
Variation Rhythms of Lymphocyte Subsets during Healthy Aging
Faria, A. M. C., de Moraes, S. M., de Freitas, L. H. F., Speziali, E., Soares, T. F., Neves, S. P. F., Vitelli-Avelar, D. M., Martins, M. Â., Barbosa, K. V. B. D., Soares, E. B., et al. (2008) · NeuroImmunoModulation · doi:10.1159/000156478 · Cited by 59 · see citing works
Self-citationTelomere Length in Human Adults and High Level Natural Background Radiation
Das, B., Saini, D., & Seshadri, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008440 · Cited by 56 · see citing works
Cytomegalovirus seroprevalence and ‘cytomegalovirus-safe’ seropositive blood donors
Badami, K. G., McQUILKAN-BICKERSTAFFE, S., Wells, J. E., & PARATA, M. (2009) · Epidemiology and Infection · doi:10.1017/s0950268809990094 · Cited by 21 · see citing works
Pillat, M. M., Correa, B. L., da Rocha, C. F. K., Müller, G. C., Lopes, R. P., Lampert, S. S., Teixeira, A. L., Menna-Barreto, M., & Bauer, M. E. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.08.016 · Cited by 13 · see citing works
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Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Darrow, S. M., Verhoeven, J. E., Révész, D., Lindqvist, D., Penninx, B. W. J. H., Delucchi, K. L., Wolkowitz, O. M., & Mathews, C. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000356 · Cited by 229 · see citing works
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder
Fries, G. R., Bauer, I. E., Scaini, G., Wu, M., Kazimi, I. F., Valvassori, S. S., Zunta‐Soares, G. B., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0048-8 · Cited by 162 · see citing works
Medical comorbidity in bipolar disorder: The link with metabolic-inflammatory systems
SayuriYamagata, A., Brietzke, E. M., Rosenblat, J. D., Kakar, R., & McIntyre, R. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.059 · Cited by 153 · see citing works
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Teixeira, A. L., Gama, C. S., Rocha, N. P., & Teixeira, M. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00241 · Cited by 129 · see citing works
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Self-citationFries, G. R., Zamzow, M. J., Andrews, T., Pink, O., Scaini, G., & Quevedo, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.035 · Cited by 110 · see citing works
Avramopoulos, D., Pearce, B. D., McGrath, J. A., Wolyniec, P. S., Wang, R., Eckart, N., Hatzimanolis, A., Goes, F. S., Nestadt, G., Mulle, J. G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116696 · Cited by 111 · see citing works
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Xu, W., Wong, G. C. L., Hwang, Y. Y., & Larbi, A. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00824-x · Cited by 104 · see citing works
Huang, Y., Wang, L., Tseng, P., Hung, C., & Lin, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.035 · Cited by 73 · see citing works
Squassina, A., Pisanu, C., Congiu, D., Caria, P., Frau, D. V., Niola, P., Melis, C., Baggiani, G., López, J. P., Cruceanu, C., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.020 · Cited by 72 · see citing works
Panizzutti, B., Gubert, C., Schuh, A. L., Ferrari, P., Bristot, G., Fries, G. R., Massuda, R., Walz, J. C., Rocha, N. P., Berk, M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.010 · Cited by 66 · see citing works
Self-citationOkazaki, S., Numata, S., Otsuka, I., Horai, T., Kinoshita, M., Sora, I., Ohmori, T., & Hishimoto, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0813-y · Cited by 65 · see citing works
Analysis of telomere attrition in bipolar disorder
Lima, I. M. M., Barros, A. G. A., Rosa, D. V., Albuquerque, M. R., Malloy‐Diniz, L. F., Neves, F. S., Romano‐Silva, M. A., & de Miranda, D. M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.043 · Cited by 61 · see citing works
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Barbé‐Tuana, F. M., Parisi, M. M., Panizzutti, B., Fries, G. R., Grün, L. K., Guma, F. T. C. R., Kapczinski, F. P., Berk, M., Gama, C. S., & Rosa, A. R. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-1910 · Cited by 59 · see citing works
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Frye, M. A., Coombes, B. J., McElroy, S. L., Jones-Brando, L., Bond, D. J., Veldić, M., Romo‐Nava, F., Bobo, W. V., Singh, B., Colby, C. L., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.2499 · Cited by 57 · see citing works
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Otsuka, I., Izumi, T., Boku, S., Kimura, A., Zhang, Y., Mouri, K., Okazaki, S., Shiroiwa, K., Takahashi, M., Ueno, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03599-8 · Cited by 62 · see citing works
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Squassina, A., Pisanu, C., & Vanni, R. (2019) · Cells · doi:10.3390/cells8010052 · Cited by 54 · see citing works
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Colpo, G. D., Leffa, D. D., Köhler, C. A., Kapczinski, F. P., Quevedo, J., & Carvalho, A. F. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.034 · Cited by 53 · see citing works
Magioncalda, P., Martino, M., Tardito, S., Sterlini, B., Conio, B., Marozzi, V., Adavastro, G., Capobianco, L., Russo, D., Parodi, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.017 · Cited by 46 · see citing works
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Monroy‐Jaramillo, N., Dyukova, E., & Walss‐Bass, C. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1273550 · Cited by 37 · see citing works
Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders
Sheffield, J. M., Rogers, B. P., Blackford, J. U., Heckers, S., & Woodward, N. D. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.016 · Cited by 35 · see citing works
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Pisanu, C., Congiu, D., Manchia, M., Caria, P., Cocco, C., Dettori, T., Frau, D. V., Manca, E., Meloni, A., Nieddu, M., et al. (2020) · Pharmacogenomics · doi:10.2217/pgs-2020-0028 · Cited by 35 · see citing works
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Yamagata, A. S., Mansur, R. B., Rizzo, L. B., Rosenstock, T. R., McIntyre, R. S., & Brietzke, E. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.010 · Cited by 29 · see citing works
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Self-citationLundberg, M., Biernacka, J. M., Lavebratt, C., Druliner, B. R., Ryu, E., Geske, J. R., Colby, C. L., Boardman, L., Frye, M. A., & Schalling, M. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112865 · Cited by 24 · see citing works
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Soeiro‐de‐Souza, M. G., Teixeira, A. L., Mateo, E. C. C., Zanetti, M. V., Rodrigues, F. G., de Paula, V. D. J. R., Bezerra, J. F., Moreno, R. A., Gattaz, W. F., & Machado‐Vieira, R. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.005 · Cited by 23 · see citing works
Self-citationZheng, H., & Savitz, J. B. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_361 · Cited by 18 · see citing works
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Jones, G. H., Rong, C., Shariq, A. S., Mishra, A. P., & Machado‐Vieira, R. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_157 · Cited by 18 · see citing works
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Snijders, G. J. L., van Mierlo, H. C., Boks, M. P., Begemann, M., Sutterland, A. L., Litjens, M., Ophoff, R. A., Kahn, R. S., & de Witte, L. D. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0636-x · Cited by 17 · see citing works
Therapeutic Implications of the Microbial Hypothesis of Mental Illness
Savitz, J. B., & Yolken, R. H. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_368 · Cited by 16 · see citing works
Simões, L. R., Abreu, R. R. E. S., Generoso, J. S., Goularte, J. A., Collodel, A., Giridharan, V. V., Arumanayagam, A. C. S., Valvassori, S. S., Quevedo, J., & Barichello, T. (2017) · Mediators of Inflammation · doi:10.1155/2017/6490652 · Cited by 14 · see citing works
Ferensztajn‐Rochowiak, E., Kurczewska, E., Rubiś, B., Lulkiewicz, M., Hołysz, H., Rybakowski, F., & RYBAKOWSKI, J. K. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.20 · Cited by 13 · see citing works
Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health
Ford, B. N., & Savitz, J. B. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_376 · Cited by 12 · see citing works
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Teixeira, A. L., Scholl, J. N., & Bauer, M. E. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4200-9_4 · Cited by 9 · see citing works
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Martínez, D., Lavebratt, C., Millischer, V., de Paula, V. D. J. R., Pires, T. D. O., Michelon, L., Camilo, C., Esteban, N., Pereira, A. C., Schalling, M., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275999 · Cited by 11 · see citing works
Yamagata, A. S., Rizzo, L. B., Cerqueira, R. O., Scott, J. L., Cordeiro, Q., McIntyre, R. S., Mansur, R. B., & Brietzke, E. M. (2017) · Complex Psychiatry · doi:10.1159/000486396 · Cited by 9 · see citing works
Self-citationShmeleva, E. V., Boag, S. E., Murali, S., Bennaceur, K., Das, R., Egred, M., Purcell, I. F., Edwards, R., Todryk, S. M., & Spyridopoulos, I. (2015) · Immunity Inflammation and Disease · doi:10.1002/iid3.49 · Cited by 8 · see citing works
Solh, T., & Cevher, Ş. C. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115528 · Cited by 7 · see citing works
Epigenetic aging in Williams syndrome
Okazaki, S., Kimura, R., Otsuka, I., Tomiwa, K., Funabiki, Y., Hagiwara, M., Murai, T., & Hishimoto, A. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13613 · Cited by 7 · see citing works
Ozbek, S. U., Akyol, K., & Bora, E. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.07.007 · Cited by 5 · see citing works
The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention
Müller, L., & Pawelec, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00016-0 · Cited by 5 · see citing works
Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?
Ioannou, M., Simon, M. S., Borkent, J., Wijkhuijs, A. J. M., Berghmans, R., Haarman, B. C. M., & Drexhage, H. A. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100764 · Cited by 4 · see citing works
The conundrum of the connection between severe psychiatric disorders and dementia
Teixeira, A. L., de Erausquin, G. A., & Olvera, R. L. (2025) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2024-0223 · Cited by 4 · see citing works
Self-citationMachado‐Vieira, R. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.083 · Cited by 4 · see citing works
Ormerod, M. B. E. G., Ueland, T., Aas, M., Hjell, G., Rødevand, L. N., Sæther, L. S., Lunding, S. H., Johansen, I. T., Mlakar, V., Andreou, D., et al. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.62 · Cited by 5 · see citing works
Interventions Addressing the Telomere-Telomerase System
Muneer, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_26 · Cited by 3 · see citing works
Müller, L., & Pawelec, G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00015-0 · Cited by 3 · see citing works
Viewing Psychiatric Disorders Through Viruses: Simple Architecture, Burgeoning Implications
Kong, L., Zhu, B., Zhuang, Y., Lai, J., & Hu, S. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01443-y · Cited by 2 · see citing works
Guo, X., Chen, Y., Huang, H., Liu, Y., Kong, L., Chen, L., Lyu, H., Gao, T., Lai, J., Zhang, D., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.06.014 · Cited by 2 · see citing works
Is Depression Associated With Accelerated Aging? Mechanisms and Implications
Lindqvist, D., Simon, N. M., & Wolkowitz, O. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00019-6 · Cited by 2 · see citing works
Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis
Lu, L., Zeng, H., Wan, B., & Sun, M. (2023) · PeerJ · doi:10.7717/peerj.15129 · Cited by 2 · see citing works
A multi-omics analysis of gut bacteriome, virome, and serum metabolome in bipolar depression
Kong, L., Zhuang, Y., Zhu, B., Wang, H., Chen, Y., Shen, Y., Feng, X., Hu, S. S., & Lai, J. (2026) · npj Mental Health Research · doi:10.1038/s44184-026-00197-3 · Cited by 1 · see citing works
Valiati, F. E., Hizo, G. H., Pinto, J. V., & Kauer‐Sant’Anna, M. (2019) · Current Psychiatry Research and Reviews · doi:10.2174/1573400515666190719155906 · Cited by 1 · see citing works
Emerging Concepts in Chemical and Biological Sciences
Bose, A., Bhaduri, A., Gupta, S., Saha, A., Das, L., Palit, S., Dasgupta, D., Patra, M. D., Bakra, D., Sarkar, L., et al. (2020) · Lincoln Research and Publications Limited, Australia in Collaboration with Lincoln University College, Malaysia eBooks · doi:10.46977/book.2020.eccbs · Cited by 1 · see citing works
Neuroimmune pathways in bipolar disorder
Barbosa, I. G., Bauer, M. E., & Teixeira, A. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00003-5 · Cited by 1 · see citing works
Self-citationExploración de un modelo de estadiaje clínico aplicado al trastorno bipolar
Tatay, A. (2015) · Dialnet (Universidad de la Rioja)
Aw, T.-R., & Chapman, J. (2015) · Journal of Immunology and Infectious Diseases · doi:10.15744/2394-6512.1.205
Investigação do comprimento telomérico em famílias com vários afetados pelo transtorno bipolar
Martinez, D. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2018.tde-06042018-121637
Bipolar disorder and accelerated aging: Shared mechanisms and implications
Wieck, A., Bauer, M. E., & Teixeira, A. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00028-4
Self-citationRole of Regulatory Immune Cells in Psychiatric Disorders
Balcioglu, S. S. K., & Balcıoğlu, Y. H. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_5
Telomere length in bipolar disorder: An updated meta-analysis of observational studies
Hung, T.-H., Chen, I.-L., Huang, Y.-C., & Lin, P. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117092
- Authors
- Rizzo, L. B., Do Prado, C. H., Grassi-Oliveira, R., Wieck, A., Correa, B. L., Teixeira, A. L., & Bauer, M. E.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Laboratory of Immunosenescence; Institute of Biomedical Research; Pontifical Catholic University of the Rio Grande do Sul (PUCRS); Porto Alegre
- Translational Psychoneuroimmunology Group; UFMG; Belo Horizonte Brazil
- Corresponding author
- Bauer, Moisés Evandro
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2013-09-10
- Volume
- 15
- Issue
- 8
- Pages
- 832-838
- ISSN
- 1398-5647 (ISSN-L)
- OpenAlex
- W2035530166
- Cited by
- 73
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- immunosenescence, human cytomegalovirus, telomere length, accelerated aging, CD8+CD28- T cells, natural killer cells, NKT cells, CMV serology, low-grade inflammation
- MeSH terms
- Adult, Aging, Analysis of Variance, Bipolar Disorder, Cytomegalovirus, Female, Flow Cytometry, Humans, Immunoglobulins, Lymphocytes, Middle Aged, Antigens, CD, Case-Control Studies, Telomere, Lithium Chloride, Antimanic Agents, Statistics, Nonparametric
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