Appetite‐regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers
Abstract
Objective: Shift work is associated with circadian rhythm disorder, impaired sleep and behavioural changes, including eating habits, predisposing to obesity and metabolic dysfunctions. It involves a neuro‐hormonal dysregulation of appetite towards positive energy balance, including increased ghrelin and decreased leptin, but little is known about other hormones, such as xenin, derived from the upper gut (like ghrelin), and lower gut hormones. Our objective was to compare night workers with day workers in relation to appetite‐regulating hormones and other metabolic parameters. Design: Cross‐sectional, observational study. Participants: Twenty‐four overweight women, divided into night shift workers (n = 12) and day shift workers (n = 12). Measurements: BMI, waist circumference, fat mass percentage; diet composition; Pittsburgh Sleep Quality Index; lipids; adipokines; meal tolerance test curves of glucose, insulin, ghrelin, PYY 3‐36, oxyntomodulin, xenin, GLP‐1; insulin sensitivity (Stumvoll index). Results: Night workers, as compared with day workers, had greater body fat mass percentage and tendency to greater waist circumference despite similar BMI; greater energy intake; impaired sleep; lower insulin sensitivity; increased triglycerides and tendency to increased C‐reactive protein; similar levels of leptin and other adipokines. Night workers had a blunted post‐meal suppression of ghrelin (AUC i 0–60 min 19·4 ± 139·9 vs −141·9 ± 9·0 ng/ml·60 min, P < 0·01); blunted rise of xenin (AUC0–180 min 8690·9 ± 2988·2 vs 28 504·4 ± 20 308·3 pg/ml·180 min, P < 0·01) and similar curves of PYY 3‐36, oxyntomodulin and GPL‐1. Conclusion: Compared with day workers within the same BMI range, night workers presented a disrupted control of ghrelin and xenin, associated with behavioural changes in diet and sleep and increased adiposity and related metabolic alterations.
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- Authors
- Schiavo‐Cardozo, D., Lima, M. M. O., Pareja, J. C., & Geloneze, B.
- Affiliations
- Laboratory of Investigation in Metabolism and Diabetes (LIMED)/Gastrocentro State University of Campinas (UNICAMP) Campinas São Paulo Brazil
- Universidade Estadual de Campinas (UNICAMP) (BR)
- ORCID
- Geloneze, Bruno
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2013-04-05
- Volume
- 79
- Issue
- 6
- Pages
- 807-811
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2033456007
- Cited by
- 96
- References
- 21
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 4
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- shift work, night shift workers, ghrelin, xenin, appetite-regulating hormones, circadian rhythm disorders, sleep quality, insulin sensitivity, adiposity, fat mass, PYY3-36, oxyntomodulin, glucagon-like peptide-1, leptin, adipokines, triglycerides, C-reactive protein, energy intake, obesity
- MeSH terms
- Adult, Appetite Regulation, Energy Intake, Cross-Sectional Studies, Digestive System, Female, Gastrointestinal Hormones, Humans, Insulin Resistance, Neurotensin, Peptide Fragments, Work Schedule Tolerance, Peptide YY, Sleep Disorders, Circadian Rhythm, Adiposity, Overweight, Glucagon-Like Peptide 1, Oxyntomodulin, Ghrelin
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