Obesity and shift work: chronobiological aspects
Open accessAbstract
The present review has the objective of summarising chronobiological aspects of shift work and obesity. There was a systematic search in PubMed databases, using the following descriptors: shift work; obesity; biological clock. Shift work is extremely frequent in several services and industries, in order to systematise the needs for flexibility of the workforce, necessary to optimise productivity and business competitiveness. In developing countries, this population represents a considerable contingent workforce. Recently, studies showed that overweight and obesity are more prevalent in shift workers than day workers. In addition, the literature shows that shift workers seem to gain weight more often than those workers submitted to a usual work day. In conclusion, there is considerable epidemiological evidence that shift work is associated with increased risk for obesity, diabetes and CVD, perhaps as a result of physiological maladaptation to chronically sleeping and eating at abnormal circadian times. The impact of shift work on metabolism supports a possible pathway to the development of obesity and its co-morbities. The present review demonstrated the adverse cardiometabolic implications of circadian misalignment, as occurs chronically with shift workers.
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Long-term desynchronization of circadian rhythms is associated with adverse metabolic health effects, including weight gain, increased body fat, obesity, impaired glucose tolerance, insulin resistance, higher blood pressure, elevated cholesterol levels, and elevated risk for cardiovascular diseases, diabetes, and metabolic syndrome.
“Long-term desynchronization of circadian rhythms is associated with adverse metabolic health effects, including weight gain, increased body fat, obesity, impaired glucose tolerance, insulin resistance, higher blood pressure, and elevated cholesterol levels, as well as elevated risk for cardiovascular diseases, diabetes, and metabolic syndrome (18, 47–54).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [47]
The “Shift work v. metabolic disturbances” section links chronic sleep–wake reversal and desynchronisation to metabolic syndrome, and reports associations of shift work with weight gain, insulin resistance, diabetes and cardiovascular disease (page unavailable). It also reports higher cholesterol in some shift-worker studies, but says another study did not find that association. Crucially, it says the observed increase in blood pressure could reflect desynchronisation, overweight, or both, so the source does not establish every listed outcome as an association with long-term circadian desynchronisation itself. (LLM, conf=0.84)
Experimental — accuracy not yet measuredShift work is a risk factor for diabetes, obesity, and cardiovascular disease.
“Shift work is a risk factor for diabetes, obesity, and cardiovascular disease (63)(64)(65)(66).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [64]
The increased risk of type 2 diabetes associated with rotating night shift work is consistent with previously reported positive associations of rotating shift work with obesity and/or weight gain, metabolic syndrome, and cardiovascular disease.
“The increased risk of type 2 diabetes associated with rotating night shift work is also consistent with previously reported positive associations of rotating shift work with obesity and/or weight gain [2], metabolic syndrome [3],[4], and cardiovascular disease [16].”
From Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women (2011) · cites this paper as [2]
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- Authors
- Antunes, L. C., Levandovski, R., Dantas, G., Caumo, W., & Hidalgo, M. P.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Hidalgo, M. P.
- Venue
- Nutrition Research Reviews
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-02-02
- Volume
- 23
- Issue
- 1
- Pages
- 155-168
- ISSN
- 0954-4224 (ISSN-L)
- 1475-2700
- OpenAlex
- W2002226343
- Cited by
- 493
- References
- 97
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 33 · 2023: 35 · 2022: 40 · 2021: 30 · 2020: 37 · 2019: 41 · 2018: 34 · 2017: 41 · 2016: 39 · 2015: 33 · 2014: 33 · 2013: 26 · 2012: 22
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nutrition Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade Federal do Rio Grande do Sul
- Fundação Instituto de Pesquisas Econômicas
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- shift work, obesity, circadian misalignment, biological clock, circadian rhythm, cardiometabolic risk, diabetes mellitus, cardiovascular disease, metabolism, overweight
- MeSH terms
- Anthropometry, Blood Glucose, Cardiovascular Diseases, Chronobiology Phenomena, Circadian Rhythm, Eating, Humans, Hyperlipidemias, Insulin, Obesity, Risk Factors, Work Schedule Tolerance, Exercise, Randomized Controlled Trials as Topic, Metabolic Syndrome, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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