Gestational stress induces persistent depressive‐like behavior and structural modifications within the postpartum nucleus accumbens

Haim, Achikam; Sherer, Morgan; Leuner, Benedetta

doi:10.1111/ejn.12752

Cited by 76Maternal Mental Health During Pregnancy and PostpartumStress Responses and CortisolNeuroendocrine regulation and behavior

Gestational stress induces persistent depressive‐like behavior and structural modifications within the postpartum nucleus accumbens

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Haim, Achikam, Sherer, Morgan, Leuner, Benedetta·2014·European Journal of Neuroscience

DOI 10.1111/ejn.12752PMC PMC4488909

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Abstract

Postpartum depression (PPD) is a common complication following childbirth experienced by one in every five new mothers. Pregnancy stress enhances vulnerability to PPD and has also been shown to increase depressive‐like behavior in postpartum rats. Thus, gestational stress may be an important translational risk factor that can be used to investigate the neurobiological mechanisms underlying PPD. Here we examined the effects of gestational stress on depressive‐like behavior during the early/mid and late postpartum periods and evaluated whether this was accompanied by altered structural plasticity in the nucleus accumbens (NA c), a brain region that has been linked to PPD. We show that early/mid (postpartum day 8) postpartum female rats exhibited more depressive‐like behavior in the forced swim test as compared with late postpartum females (postpartum day 22). However, 2 weeks of restraint stress during pregnancy increased depressive‐like behavior regardless of postpartum timepoint. In addition, dendritic length, branching and spine density on medium spiny neurons in the NA c shell were diminished in postpartum rats that experienced gestational stress although stress‐induced reductions in spine density were evident only in early/mid postpartum females. In the NA c core, structural plasticity was not affected by gestational stress but late postpartum females exhibited lower spine density and reduced dendritic length. Overall, these data not only demonstrate structural changes in the NA c across the postpartum period, they also show that postpartum depressive‐like behavior following exposure to gestational stress is associated with compromised structural plasticity in the NA c and thus may provide insight into the neural changes that could contribute to PPD.

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NAc MSN spine density, dendritic length, and branch points are decreased after stress hormone corticosterone or gestational stress.
“NAc MSN spine density, dendritic length, and branch points are decreased after stress hormone corticosterone [149] or gestational stress [150].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [150]

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Authors: Haim, A., Sherer, M., & Leuner, B.
Affiliations: The Ohio State University Wexner Medical Center (US)
The Ohio State University (US)
Corresponding author: Leuner, Benedetta
ORCID: Sherer, Morgan
Leuner, Benedetta
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2014-10-31
Volume: 40
Issue: 12
Pages: 3766-3773
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/ejn.12752
PMC: PMC4488909
OpenAlex: W2030155128
Cited by: 76
References: 89
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 12 · 2015: 6
FWCI: 8.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Health (R0084148)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: postpartum depression, prenatal stress, restraint stress, nucleus accumbens, depression-like behavior, dendritic spine density, medium spiny neurons, structural plasticity, postpartum period, forced swim test, maternal mental health
MeSH terms: Animals, Dendrites, Disease Models, Animal, Female, Neuronal Plasticity, Nucleus Accumbens, Pregnancy, Pregnancy Complications, Random Allocation, Restraint, Physical, Stress, Psychological, Weight Gain, Rats, Sprague-Dawley, Depression, Postpartum

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Gestational stress induces persistent depressive‐like behavior and structural modifications within the postpartum nucleus accumbens

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