From stress to postpartum mood and anxiety disorders: How chronic peripartum stress can impair maternal adaptations
Open accessAbstract
The peripartum period, in all mammalian species, is characterised by numerous adaptations at neuroendocrine, molecular and behavioural levels that prepare the female for the challenges of motherhood. These changes have been well characterised and, while they are necessary to ensure the survival and nurturance of the offspring, there is growing belief that they are also required for maternal mental health. Thus, while increased calmness and attenuated stress responsivity are common characteristics of the peripartum period, it also represents a time of increased susceptibility to mood disorders. While a number of risk factors for these disorders are known, their underlying aetiology remains poorly understood, due at least in part to a lack of appropriate animal models. One translatable risk factor is stress exposure during the peripartum period. In the following review we first describe common peripartum adaptations and the impact postpartum mood disorders have on these. We then discuss the known consequences of peripartum stress exposure on such maternal adaptations that have been described in basic research.
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Mood changes could reflect potential dysfunctions of adaptation to the environment and might contribute to symptoms of mood disorders.
“it is postulated that mood changes could reflect the potential dysfunctions of the adaption to our environment and that it might contribute to the symptoms of mood disorders [12,20,21].”
From Acceptance Mindfulness-Trait as a Protective Factor for Post-Natal Depression: A Preliminary Research (2022) · cites this paper as [21]
The Conclusions (page unavailable) say that maternal adaptations help mothers respond to their changing situation and that chronic pregnancy stress can impair these adaptations alongside increased anxiety- and depression-related behaviour. The paper concerns pregnancy and postpartum, however; it does not make the broader claim about mood changes reflecting dysfunctions in adaptation to the environment generally or contributing to mood-disorder symptoms. (LLM, conf=0.84)
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Buss, C., Entringer, S., Moog, N. K., Toepfer, P., Fair, D. A., Simhan, H. N., Heim, C. M., & Wadhwa, P. D. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.03.001 · Cited by 250 · see citing works
The maternal brain: an organ with peripartal plasticity
Hillerer, K. M., Jacobs, V. R., Fischer, T., & Aigner, L. (2014) · Neural Plasticity · doi:10.1155/2014/574159 · Cited by 120 · see citing works
Self-citationHaim, A., Sherer, M., & Leuner, B. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12752 · Cited by 76 · see citing works
Chen, H., Lai, J. C., Hwang, S., Huang, N., Chou, Y., & Chien, L. (2017) · Birth · doi:10.1111/birt.12295 · Cited by 67 · see citing works
Tharwat, D., Trousselard, M., Fromage, D., Belrose, C., Balès, M., Sutter-Dallay, A.-L., Ezto, M.-L., Hurstel, F., Harvey, T., Martin, S., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031545 · Cited by 3 · see citing works
“Since mood could represent the overall momentum, and its biasing is considered to influence on the perception of our environment, it is postulated that mood changes could reflect the potential dysfunctions of the adaption to our environment and that it might contribute to the symptoms of mood disorders [12,20,21].”
Background
- Authors
- Hillerer, K. M., Neumann, I. D., & Slattery, D. A.
- Affiliations
- University of Regensburg (DE)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2011-10-26
- Volume
- 95
- Issue
- 1
- Pages
- 22-38
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1990450569
- Cited by
- 82
- References
- 223
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- postpartum mood disorders, postpartum anxiety, maternal mental health, maternal adaptation, stress responsivity, neuroendocrine adaptation, maternal behavior
- MeSH terms
- Adaptation, Psychological, Animals, Anxiety Disorders, Female, Humans, Hypothalamo-Hypophyseal System, Male, Maternal Welfare, Pituitary-Adrenal System, Pregnancy, Risk Factors, Stress, Psychological, Depression, Postpartum, Models, Animal, Rats, Peripartum Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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