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Cited by 386Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesFace Recognition and Perception

An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice

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Choleris, Elena, Gustafsson, Jan-Åke, Korach, Kenneth S., Muglia, Louis J., Pfaff, Donald W., Ogawa, Sonoko·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0631699100PMC PMC156348
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Abstract

Estrogens control many physiological and behavioral processes, some of which are connected to reproduction. These include sexual and other social behaviors. Here we implicate four gene products in a micronet required for mammalian social recognition, through which an individual learns to recognize other individuals. Female mice whose genes for the neuropeptide oxytocin (OT) or the estrogen receptor (ER)-β or ER-α had been selectively “knocked out” were deficient specifically in social recognition and social anxiety. There was a remarkable parallelism among results from three separate gene knockouts. The data strongly suggest the involvement in social recognition of the four genes coding for ER-α, ER-β, OT, and the OT receptor. We thus propose here a four-gene micronet, which links hypothalamic and limbic forebrain neurons in the estrogen control over the OT regulation of social recognition. In our model, estrogens act on the OT system at two levels: through ER-β, they regulate the production of OT in the hypothalamic paraventricular nucleus, and through ER-α, they drive the transcription of the OT receptor in the amygdala. The proper operation of a social recognition mechanism allows for the expression of appropriate social behaviors, aggressive or affiliative.

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  • Estrogens improve social recognition in mice through estrogen receptors.

    “estrogens are known to improve social recognition in mice through estrogen receptors [18, 19]”

    From Effects of sex and gonadectomy on social investigation and social recognition in mice (2015) · cites this paper as [18]

  • Estrogen receptor-alpha, and to some extent estrogen receptor-beta, are crucial for social memory in females.

    “A number of investigations have shown that estrogen receptor-alpha, and to some extent estrogen receptor-beta, are crucial for social memory in females [18, 29, 30].”

    From Effects of sex and gonadectomy on social investigation and social recognition in mice (2015) · cites this paper as [18]

  • ERβ is one component of a "four-gene micronet" regulating social recognition via the PVN, amygdala, and olfactory system.

    “ERβ has also been identified as one component of a “four-gene micronet” regulating social recognition (7, 131) via the PVN, amygdala, and olfactory system.”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [131]

  • By this model, estradiol simultaneously acts through ERβ in the PVN to increase OT, and ERα in the amygdala to increase OTR expression.

    “By this model, estradiol simultaneously acts through ERβ in the PVN to increase OT, and ERα in the amygdala to increase OTR expression.”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [131]

  • Pathways coordinating social recognition are regulated by estrogen, with both ERα and ERβ knockout mice showing social impairments, and ERβ knockout females failing to generate OT or AVP mRNA expression in response to exogenous estrogen.

    “Pathways coordinating social recognition are well known to be regulated by estrogen, with both ERα and ERβ knockout mice showing social impairments (130, 131), and ERβ knockout females failing to generate OT or AVP mRNA expression in response to exogenous estrogen administration (132, 133).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [131]

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Cited by

Sorted by citations

Authors
Choleris, E., Gustafsson, J.-Å., Korach, K. S., Muglia, L. J., Pfaff, D. W., & Ogawa, S.
Affiliations
  • Karolinska Institutet (SE)
  • Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021; Department of Medical Nutrition, Karolinska Institute, S-14186 Huddinge, Sweden; Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; and Department of Pediatrics, Washington University Pain Center, Washington University, St. Louis, MO 63110
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-05-02
Volume
100
Issue
10
Pages
6192-6197
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0631699100
PMC
PMC156348
OpenAlex
W2069519651
Cited by
386
References
2
Citations by year
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FWCI
28.72
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
social recognition, oxytocin, estrogen receptor alpha, estrogen receptor beta, oxytocin receptor, knockout mice, social anxiety, hypothalamic paraventricular nucleus, amygdala, female mice
MeSH terms
Animals, Female, Models, Neurological, Oxytocin, Pattern Recognition, Visual, Receptors, Estrogen, Social Behavior, Mice, Knockout, Estrogen Receptor alpha, Estrogen Receptor beta, Mice

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