Multifunctional intracellular matrix metalloproteinases: implications in disease

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Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

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Matrix Metalloproteinases as Modulators of Inflammation

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Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview

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Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury

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Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

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Tissue inhibitors of metalloproteinases

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Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

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Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure

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Matrix Metalloproteinase-2 Contributes to Ischemia-Reperfusion Injury in the Heart

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The surprising complexity of signal sequences

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Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

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Release of gelatinase A during platelet activation mediates aggregation

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Reactive Nitrogen Species: Molecular Mechanisms and Potential Significance in Health and Disease

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Regulation of Membrane Type-1 Matrix Metalloproteinase Activation by Proprotein Convertases

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The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts

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Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases

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Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2

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Intracellular Targets of Matrix Metalloproteinase-2 in Cardiac Disease: Rationale and Therapeutic Approaches

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Matrix Metalloproteinases in Myocardial Infarction and Heart Failure

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Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases: MMP, ADAM and ADAMTS in pathology

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Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis

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A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

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Degradation of Myosin Light Chain in Isolated Rat Hearts Subjected to Ischemia-Reperfusion Injury: A New Intracellular Target for Matrix Metalloproteinase-2

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Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

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Matrix metalloproteinase‐2 (MMP‐2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP‐ribose) polymerase (PARP) in vitro

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Cytoplasmic tail–dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity

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Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione

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Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

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The Low Density Lipoprotein Receptor-related Protein Modulates Levels of Matrix Metalloproteinase 9 (MMP-9) by Mediating Its Cellular Catabolism

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Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

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Titin is a Target of Matrix Metalloproteinase-2: Implications in Myocardial Ischemia/Reperfusion Injury

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Novel Transcription Factor-Like Function of Human Matrix Metalloproteinase 3 Regulating the CTGF/CCN2 Gene

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Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2

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Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction

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Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9

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Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

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Matrix Metalloproteinase 3 Is Present in the Cell Nucleus and Is Involved in Apoptosis

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New intracellular activities of matrix metalloproteinases shine in the moonlight

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Caveolae Are a Novel Pathway for Membrane-Type 1 Matrix Metalloproteinase Traffic in Human Endothelial Cells

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MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

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Macrophage elastase kills bacteria within murine macrophages

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Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases

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The history of matrix metalloproteinases: milestones, myths, and misperceptions

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Inhibition of MMP‐3 or ‐9 suppresses lipopolysaccharide‐induced expression of proinflammatory cytokines and iNOS in microglia

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Role of the hemopexin domain of matrix metalloproteinases in cell migration

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Matrix Metalloproteinase-7 Affects Connexin-43 Levels, Electrical Conduction, and Survival After Myocardial Infarction

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Nuclear localization of Matrix metalloproteinases

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Matrix metalloproteinase-2 degrades the cytoskeletal protein α-actinin in peroxynitrite mediated myocardial injury

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Regulation of matrix metalloproteinase‐2 (MMP‐2) activity by phosphorylation

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Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

Kowluru, R. A., Mohammad, G., dos Santos, J. M., & Zhong, Q. P. W. (2011) · Diabetes · doi:10.2337/db11-0816 · Cited by 153

Connective tissue growth factor (CTGF) and cancer progression

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Ischaemia–reperfusion injury activates matrix metalloproteinases in the human heart

Lalu, M. M., Pasini, E., Schulze, C. J., Ferrari-Vivaldi, M., Ferrari, G., Bachetti, T., & Schulz, R. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi007 · Cited by 141

Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction

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Differential vesicular distribution and trafficking of MMP‐2, MMP‐9, and their inhibitors in astrocytes

Sbai, O., Ould‐Yahoui, A., Ferhat, L., Gueye, Y., Bernard, A., Charrat, E., Mehanna, A., Risso, J., Chauvin, J., Fenouillet, E., et al. (2009) · Glia · doi:10.1002/glia.20927 · Cited by 138

Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms

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Altered Balance Between Matrix Gelatinases (MMP-2 and MMP-9) and Their Tissue Inhibitors in Human Dilated Cardiomyopathy: Potential Role of MMP-9 in Myosin-Heavy Chain Degradation

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Activation of Pro-gelatinase B by Endometase/Matrilysin-2 Promotes Invasion of Human Prostate Cancer Cells

Zhao, Y.-G., Xiao, A.-Z., Newcomer, R. G., Park, H. I., Kang, T., Chung, L. W. K., Swanson, M. G., Zhau, H. E., Kurhanewicz, J. V., & Sang, Q. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210975200 · Cited by 131

Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia

Yang, Y. R., Candelario‐Jalil, E., Thompson, J. F., Cuadrado, E., Estrada, E. Y., Rosell, A., Montaner, J., & Rosenberg, G. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06433.x · Cited by 129

A novel intracellular role of matrix metalloproteinase‐3 during apoptosis of dopaminergic cells

Choi, D. H., Kim, E., Son, H. J., JOH, T. H., Kim, Y. S., Kim, D., Beal, M. F., & Hwang, O. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05399.x · Cited by 125

Matrix Metalloproteinase-1 Associates with Intracellular Organelles and Confers Resistance to Lamin A/C Degradation during Apoptosis

Limb, G. A., Matter, K., Murphy, G., Cambrey, A. D., Bishop, P. N., Morris, G. E., & Khaw, P. T. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62371-1 · Cited by 123

MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesisPreprint

Kim, K., Punj, V., Kim, J., Lee, S., Ulmer, T. S., Lu, W., Rice, J. C., & An, W. (2016) · Genes & Development · doi:10.1101/gad.268714.115 · Cited by 120

Matrix Metalloproteinase–9 in Pneumococcal Meningitis: Activation via an Oxidative Pathway

Meli, D. N., Christen, S., & Leib, S. L. (2003) · The Journal of Infectious Diseases · doi:10.1086/374644 · Cited by 115

Low Density Lipoprotein Receptor-related Protein Mediates Endocytic Clearance of Pro-MMP-2·TIMP-2 Complex through a Thrombospondin-independent Mechanism

Emonard, H., Bellon, G., Troeberg, L., Berton, A., Robinet, A., Henriet, P., Marbaix, É., Kirkegaard, K., Patthy, L., Eeckhout, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406792200 · Cited by 115

A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Induced by Oxidative Stress Activates Innate Immunity

Lovett, D. H., Mahimkar, R., Raffaï, R. L., Cape, L., Maklashina, E., Cecchini, G., & Karliner, J. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034177 · Cited by 113

MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling

Chan, B. Y. H., Roczkowsky, A., Cho, W. J., Poirier, M., Sergi, C. M., Keschrumrus, V., Churko, J. M., Granzier, H. L. M., & Schulz, R. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa017 · Cited by 113

Vascular MMP-9/TIMP-2 and Neuronal MMP-10 Up-Regulation in Human Brain after Stroke: A Combined Laser Microdissection and Protein Array Study

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Localization and Translocation of MMP-2 during Aggregation of Human Platelets

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The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9

Monferran, S., Paupert, J., Dauvillier, S., Salles, B., & Muller, C. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600403 · Cited by 108

Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Exhibits an Important Intracellular Cleavage Function and Causes Chromosome Instability

Golubkov, V. S., Boyd, S. E., Savinov, A. Y., Chekanov, A. V., Osterman, A. L., Remacle, A. G., Rozanov, D. V., Doxsey, S., & Strongin, A. Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502779200 · Cited by 101

Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis

Lv, Y., Zhao, X., Zhu, L., Li, S., Xiao, Q., He, W., & Yin, L. (2018) · Theranostics · doi:10.7150/thno.23209 · Cited by 101

MMP-1 expression has an independent prognostic value in breast cancer

Boström, P., Söderström, M., Vahlberg, T. J., Söderström, K., Roberts, P. J., Carpén, O., & Hirsimäki, P. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-348 · Cited by 99

MT1-MMP regulates the PI3Kδ·Mi-2/NuRD-dependent control of macrophage immune functionPreprint

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Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment

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Novel Role of Mitochondrial Matrix Metalloproteinase-2 in the Development of Diabetic Retinopathy

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Targeting MMP-2 to treat ischemic heart injury

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Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer

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Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility

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Alternative Splicing and Promoter Usage Generates an Intracellular Stromelysin 3 Isoform Directly Translated as an Active Matrix Metalloproteinase

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Mechanisms of cytosolic targeting of matrix metalloproteinase‐2

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Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen–glucose deprivation in neurons

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Zinc-binding proteins (metallothionein and α-2 macroglobulin) and immunosenescence

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Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

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Matrix metalloproteinase-2 knockout prevents angiotensin II-induced vascular injury

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The Expanding Role of MT1-MMP in Cancer Progression

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Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart

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Protective action of doxycycline against diabetic cardiomyopathy in rats

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Structural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of β-Amyloid Precursor Protein-derived Inhibitor

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Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease

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Cardiac specific deletion of N -methyl- d -aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia

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Matrix Metalloproteinase 26 Proteolysis of the NH2-Terminal Domain of the Estrogen Receptor β Correlates with the Survival of Breast Cancer Patients

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Atypical localization of membrane type 1‐matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma

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MMP-2 is localized to the mitochondria-associated membrane of the heart

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Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer

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N-Terminal Truncated Intracellular Matrix Metalloproteinase-2 Induces Cardiomyocyte Hypertrophy, Inflammation and Systolic Heart Failure

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Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12

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Nonremodeling Properties of Matrix Metalloproteinases: The Platelet Connection

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α2‐Macroglobulin: A Sensor for Proteolysis

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Matrix Metalloproteinase-2 Proteolysis of Calponin-1 Contributes to Vascular Hypocontractility in Endotoxemic Rats

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Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

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Intracellular Cleavage of the Cx43 C‐Terminal Domain by Matrix‐Metalloproteases: A Novel Contributor to Inflammation?

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Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

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Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation

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Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy

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Matrix metalloproteinases contribute to endotoxin and interleukin‐1β induced vascular dysfunction

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Unconventional Activation Mechanisms of MMP-26, a Human Matrix Metalloproteinase with a Unique PHCG XXD Cysteine-switch Motif

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Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice

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Identification of a Novel Heart–Liver Axis: Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A 2 to Modulate Lipid Metabolism and Inflammation in the Liver

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NUCLEAR LOCALIZATION OF ACTIVE MATRIX METALLOPROTEINASE-2 IN CIGARETTE SMOKE-EXPOSED APOPTOTIC ENDOTHELIAL CELLS

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Glycogen synthase kinase-3 is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts

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Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

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Modulation of Systemic Metabolism by MMP‐2: From MMP‐2 Deficiency in Mice to MMP‐2 Deficiency in Patients

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Citrate Synthase Is a Novel In Vivo Matrix Metalloproteinase-9 Substrate That Regulates Mitochondrial Function in the Postmyocardial Infarction Left Ventricle

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Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study

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Matrix Metalloproteinase 3 Promotes Cellular Anti-Dengue Virus Response via Interaction with Transcription Factor NFκB in Cell Nucleus

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Matrilysins and Stromelysins in Pathogenesis and Diagnostics of Cancers

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Matrix metalloproteinase‐2 mediates ribosomal RNA transcription by cleaving nucleolar histones

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Junctophilin-2 is a target of matrix metalloproteinase-2 in myocardial ischemia–reperfusion injury

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Identification of Amino Acid Residues of the Matrix Metalloproteinase-2 Essential for Its Selective Inhibition by β-Amyloid Precursor Protein-derived Inhibitor

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Challenges with matrix metalloproteinase inhibition and future drug discovery avenues

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Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin

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Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia–reperfusion injury

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Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes

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Cleavage of neuronal synaptosomal‐associated protein of 25 kDa by exogenous matrix metalloproteinase‐7

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An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury

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Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus

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Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP)

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The role of matrix metalloproteinases in liver function and disease

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