Cited by 15Psychopathy, Forensic Psychiatry, Sexual OffendingGenomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology

Rare copy number variation in extremely impulsively violent males

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Vevera, Jan, Zarrei, Mehdi, Hartmannová, Hana, Jedličková, Ivana, Mušálková, Dita, Přistoupilová, Anna, Oliveriusová, Petra, Trešlová, Helena +12 more·2019·Genes, Brain and Behavior

Abstract

The genetic correlates of extreme impulsive violence are poorly understood, and there have been no studies that have systematically characterized a large group of affected individuals both clinically and genetically. We performed a genome-wide rare copy number variant (CNV) analysis in 281 males from four Czech prisons who met strict clinical criteria for extreme impulsive violence. Inclusion criteria included age ≥ 18 years, an ICD-10 diagnosis of Dissocial Personality Disorder, and the absence of an organic brain disorder. Participants underwent a structured psychiatric assessment to diagnose extreme impulsive violence and then provided a blood sample for genetic analysis. DNA was genotyped and CNVs were identified using Illumina HumanOmni2.5 single-nucleotide polymorphism array platform. Comparing with 10851 external population controls, we identified 828 rare CNVs (frequency ≤ 0.1% among control samples) in 264 participants. The CNVs impacted 754 genes, with 124 genes impacted more than once (2-25 times). Many of these genes are associated with autosomal dominant or X-linked disorders affecting adult behavior, cognition, learning, intelligence, specifically expressed in the brain and relevant to synapses, neurodevelopment, neurodegeneration, obesity and neuropsychiatric phenotypes. Specifically, we identified 31 CNVs of clinical relevance in 31 individuals, 59 likely clinically relevant CNVs in 49 individuals, and 17 recurrent CNVs in 65 individuals. Thus, 123 of 281 (44%) individuals had one to several rare CNVs that were indirectly or directly relevant to impulsive violence. Extreme impulsive violence is genetically heterogeneous and genomic analysis is likely required to identify, further research and specifically treat the causes in affected individuals.

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Crossref · 10.1111/gbb.12536

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  • In a recent study of dissocial personality disorder, a rare duplication of GRM7 was associated with extreme impulsive violence in a male prisoner cohort.

    “In a recent study of dissocial personality disorder, a rare duplication of GRM7 was associated with extreme impulsive violence in a male prisoner cohort (Vevera et al., 2019).”

    From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Vevera et al., 2019

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Authors
Vevera, J., Zarrei, M., Hartmannová, H., Jedličková, I., Mušálková, D., Přistoupilová, A., Oliveriusová, P., Trešlová, H., Nosková, L., Hodaňová, K., Stránecký, V., Jiřička, V., Preiss, M., Příhodová, K., Šaligová, J., Wei, J., Woodbury‐Smith, M., Bleyer, A. J., Scherer, S. W., & Kmoch, S.
Affiliations
  • Charles University (CZ)
  • Hospital for Sick Children (CA)
  • Prison Service of the Czech Republic (CZ)
  • University of New York in Prague (CZ)
  • National Institute of Mental Health (CZ)
  • University of Pavol Jozef Šafárik (SK)
  • Royal Victoria Infirmary (GB)
  • Atrium Health Wake Forest Baptist (US)
  • University of Toronto (CA)
Corresponding author
  • Vevera, Jan
  • Kmoch, Stanislav
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2018-12-03
Volume
18
Issue
6
Pages
e12536-e12536
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
OpenAlex
W2899944647
Cited by
15
References
164
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1
FWCI
0.88
Type
journal article
Language
en
Open access
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
  • Grantová Agentura České Republiky (GA14‐21903S)
  • Johns Hopkins University
  • National Institutes of Health (HHSN268200782096C)
  • National Institute on Drug Abuse
  • National Institute on Alcohol Abuse and Alcoholism
  • University of Toronto
  • Hospital for Sick Children
  • Canadian Institutes of Health Research
  • Government of Ontario
  • Canadian Institute for Advanced Research
  • Canada Foundation for Innovation
  • Genome Canada
  • European Regional Development Fund
  • Univerzita Karlova v Praze (SVV 260367/2017, PROGRES‐Q26/LF1, UNCE 204064, Research Centre program No. 9)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
copy number variation, antisocial personality disorder, violent offenders, genetic heterogeneity, recurrent CNVs, brain development, neuropsychiatric phenotypes, X-linked disorders, autosomal dominant disorder, prisoners
MeSH terms
Adolescent, Adult, Aged, Antisocial Personality Disorder, Humans, Impulsive Behavior, Male, Middle Aged, Violence, DNA Copy Number Variations

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