Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
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We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.
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ASB4 is overexpressed in adrenal glands and in adrenocortical carcinoma.
“ASB4 is overexpressed in adrenal glands (according to the Human Protein Atlas) and in adrenocortical carcinoma (according to The Cancer Genome Atlas) 104 .”
From Targeted protein degradation: expanding the toolbox (2019) · cites this paper as [104]
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- Authors
- Zheng, S., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., Kim, S., Assie, G., Morozova, O., Akbani, R., Shih, J., Hoadley, K. A., Choueiri, T. K., Waldmann, J., Mete, O., Robertson, A. G., Wu, H.-T., Raphael, B. J., Shao, L., Meyerson, M., Demeure, M. J., Beuschlein, F., Gill, A. J., Sidhu, S. B., Almeida, M. Q., Fragoso, M. C. B. V., Cope, L. M., Kebebew, E., Habra, M. A., Whitsett, T. G., Bussey, K. J., Rainey, W. E., Asa, S. L., Bertherat, J., Fassnacht, M., Wheeler, D. A., Zheng, S., Verhaak, R. G. W., Giordano, T. J., Hammer, G. D., Cherniack, A. D., Dewal, N., Moffitt, R. A., Danilova, L., Murray, B. A., Lerario, A. M., Else, T., Knijnenburg, T. A., Ciriello, G., Kim, S., Assié, G., Morozova, O., Akbani, R., Shih, J., Hoadley, K. A., Choueiri, T. K., Waldmann, J., Mete, O., Robertson, A. G., Wu, H.-T., Raphael, B. J., Meyerson, M., Demeure, M. J., Beuschlein, F., Gill, A. J., Sidhu, S. B., Almeida, M., Barisson Fragoso, M. C., Cope, L. M., Kebebew, E., Habra, M. A., Whitsett, T. G., Bussey, K. J., Rainey, W. E., Asa, S. L., Bertherat, J., Fassnacht, M., Wheeler, D. A., Benz, C., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Butterfield, Y. S. N., Carlsen, R., Dhalla, N., Guin, R., Holt, R. A., Jones, S. J. M., Kasaian, K., Lee, D., Li, H. I., Lim, L., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Park, P. J., Kroiss, M., Gao, J., Sander, C., Schultz, N., Jones, C. D., Kucherlapati, R., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Tan, D., Veluvolu, U., Wilkerson, M. D., Hayes, D. N., Ladanyi, M., Quinkler, M., Auman, J. T., Latronico, A. C., Mendonca, B. B., Sibony, M., Sanborn, Z., Bellair, M., Buhay, C., Covington, K., Dahdouli, M., Dinh, H., Doddapaneni, H., Downs, B., Drummond, J., Gibbs, R., Hale, W., Han, Y., Hawes, A., Hu, J., Kakkar, N., Kalra, D., Khan, Z., Kovar, C., Lee, S., Lewis, L., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Xi, L., Dousset, B., Groussin, L., Libé, R., Chin, L., Reynolds, S., Shmulevich, I., Chudamani, S., Liu, J., Lolla, L., Wu, Y., Yeh, J. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Shi, Y., Simons, J. V., Soloway, M. G., Wu, J., Zhang, W., Mills Shaw, K. R., Demchok, J. A., Felau, I., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. (., Davidsen, T., Crawford, C., Hutter, C. M., Sofia, H. J., Roach, J., Bshara, W., Gaudioso, C., Morrison, C., Soon, P., Alonso, S., Baboud, J., Pihl, T., Raman, R., Sun, Q., Wan, Y., Naresh, R., Arachchi, H., Beroukhim, R., Carter, S. L., Cho, J., Frazer, S., Gabriel, S. B., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Noble, M. S., Saksena, G., Schumacher, S. E., Sougnez, C., Voet, D., Zhang, H., Bowen, J., Coppens, S., Gastier-Foster, J. M., Gerken, M., Helsel, C., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Baylin, S., Herman, J. G., LoBello, J., Watanabe, A., Haussler, D., Radenbaugh, A., Rao, A., Zhu, J., Bartsch, D. K., Sbiera, S., Allolio, B., Deutschbein, T., Ronchi, C., Raymond, V. M., Vinco, M., Shao, L., Amble, L., Bootwalla, M. S., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Robinson, B., Ju, Z., Kim, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., Sircar, K., Wang, Q., Yoshihara, K., Laird, P. W., Fan, Y., Wang, W., Shinbrot, E., Reincke, M., Weinstein, J. N., Meier, S., Defreitas, T., Hammer, G. D., Giordano, T. J., & Verhaak, R. G. W.
- Affiliations
- Brown University (US)
- Universitätsklinikum Gießen und Marburg (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Würzburg (DE)
- Baylor College of Medicine (US)
- BC Cancer Agency (CA)
- University of Michigan (US)
- Translational Genomics Research Institute (US)
- University of North Carolina at Chapel Hill (US)
- The University of Sydney (AU)
- The University of Texas MD Anderson Cancer Center (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- ORCID
- Benz, Christopher
- Holt, Robert A.
- Jones, Steven J.M.
- Lim, Lynette
- Marra, Marco A.
- Mungall, Andrew J.
- Sadeghi, Sara
- Kroiss, Matthias
- Gao, Jianjiong
- Sander, Chris
- Schultz, Nikolaus
- Jones, Corbin D.
- Kucherlapati, Raju
- Mieczkowski, Piotr A.
- Perou, Charles M.
- Wilkerson, Matthew D.
- Hayes, D. Neil
- Ladanyi, Marc
- Quinkler, Marcus
- Auman, J. Todd
- Mendonca, Berenice B.
- Sibony, Mathilde
- Sanborn, Zack
- Covington, Kyle
- Dinh, Huyen
- Gibbs, Richard
- Han, Yi
- Kalra, Divya
- Khan, Ziad
- Muzny, Donna
- Dousset, Bertrand
- Groussin, Lionel
- Libé, Rossella
- Liu, Jia
- Wu, Ye
- Yeh, Jen Jen
- Hoyle, Alan P.
- Shi, Yan
- Zhang, Wei
- Felau, Ina
- Sheth, Margi
- Tarnuzzer, Roy
- Yang, Liming
- Zenklusen, Jean C.
- Zhang, Jiashan (Julia)
- Davidsen, Tanja
- Sofia, Heidi J.
- Roach, Jeffrey
- Pihl, Todd
- Sun, Qiang
- Beroukhim, Rameen
- Carter, Scott L.
- Gabriel, Stacey B.
- Getz, Gad
- Heiman, David I.
- Kim, Jaegil
- Lawrence, Michael S.
- Lin, Pei
- Noble, Michael S.
- Saksena, Gordon
- Schumacher, Steven E.
- Zhang, Hailei
- Bowen, Jay
- Coppens, Sara
- Lichtenberg, Tara M.
- Ramirez, Nilsa C.
- Zmuda, Erik
- Baylin, Stephen
- Herman, James G.
- LoBello, Janine
- Haussler, David
- Radenbaugh, Amie
- Rao, Arjun
- Zhu, Jingchun
- Bartsch, Detlef K.
- Sbiera, Silviu
- Deutschbein, Timo
- Ronchi, Cristina
- Raymond, Victoria M.
- Vinco, Michelle
- Weisenberger, Daniel J.
- Ju, Zhenlin
- Kim, Hoon
- Liu, Wenbin
- Lu, Yiling
- Mills, Gordon B.
- Sircar, Kanishka
- Wang, Qianghu
- Yoshihara, Kosuke
- Laird, Peter W.
- Wang, Wenyi
- Shinbrot, Eve
- Weinstein, John N.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 29
- Issue
- 5
- Pages
- 723-736
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC4864952
- OpenAlex
- W2346239022
- Cited by
- 657
- References
- 59
- Citations by year
- 2026: 35 · 2025: 52 · 2024: 50 · 2023: 50 · 2022: 79 · 2021: 100 · 2020: 64 · 2019: 70 · 2018: 75 · 2017: 57 · 2016: 24
- FWCI
- 83.40
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-08-08)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- NIH (5U24CA143799, 5U24CA143835, 5U24CA143840, 5U24CA143843, 5U24CA143845, 5U24CA143848, 5U24CA143858, 5U24CA143866, 5U24CA143867, 5U24CA143882, 5U24CA143883, 5U24CA144025, U54HG003067, U54HG003079, U54HG003273, P30CA16672)
- Novartis
- Bayer
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- adrenocortical carcinoma, pangenomics, driver genes, PRKAR1A, ribosomal protein L22, TRF2, cyclin E1, neurofibromatosis type 1, whole-genome duplication, TERT expression, telomere length, cell cycle activation, tumor subtypes, DNA methylation signature, patient stratification
- MeSH terms
- Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Male, Middle Aged, Mutation, Prognosis, Genome, Human, Gene Expression Regulation, Neoplastic, Outcome Assessment, Health Care, Adrenocortical Carcinoma, Disease-Free Survival, DNA Methylation, Genetic Predisposition to Disease, Gene Expression Profiling, Genomics, Young Adult
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