The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention
Open accessAbstract
Summary: Background : Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear. Aim : To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms. Methods : A total of 103 patients fulfilling the Rome I or II criteria took part in this 6‐month, randomized, double‐blind placebo‐controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded. Results : At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: −13.9 to −1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non‐significant trend. Conclusions : The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.
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“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
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In the citing paper
“Furthermore, two different multispecies probiotics have shown favourable effects on symptoms of IBS: a combination of two lactobacilli, one bifidobacteria and one propionic acid bacteria, 10 as well as a combination of eight strains, VSL#3. 11, 12”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“Most of the products provided daily doses in the range of 5-9 • 10 9 cfu and, in most cases, reductions in symptom severity score were observed [17][18][19][20][21] and some, but not all, of the products significantly reduced abdominal pain symptoms.”
From Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study (2009) · cites this paper as [19]
In the citing paper
“We have recently shown in a clinical trial that a multispecies probiotic significantly alleviates IBS symptoms, but the mechanisms behind the effects are not known. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“The results of this study are consistent with our previous findings concerning a similar multispecies probiotic. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“the two strains of B. breve included in the table were tested together with some of these bacteria [139,141] , or even with prebiotics such as galacto-oligosaccharides [140]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [139]
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“Specific probiotics help relieve overall symptom burden in some patients with IBS High [147,149,150,152,156-157,169, 174,176-178]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
In the citing paper
“Specific probiotics help reduce bloating/distension in some patients with IBS Moderate [147,149-150,155-156,168-170, 174-177,179-183]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
In the citing paper
“With specific probiotics, improvement of symptoms has been shown to lead to improvement in some aspects of health-related quality of life Moderate [147,150,152,155,169-170,174,176-177,179-180,183-184,186]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
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Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
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Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
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Metadata
- Authors
- KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R.
- Affiliations
- University of Helsinki (FI)
- Valio (Finland) (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- KORPELA, R.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2005-08-26
- Volume
- 22
- Issue
- 5
- Pages
- 387-394
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2001065399
- Cited by
- 361
- References
- 37
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 25 · 2013: 23 · 2012: 30
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Valio
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, probiotics, Lactobacillus rhamnosus GG, abdominal pain, abdominal distension, flatulence, borborygmi, bowel habits, Rome criteria
- MeSH terms
- Adult, Aged, Defecation, Double-Blind Method, Female, Humans, Lactobacillus, Life Style, Male, Medical Records, Middle Aged, Propionibacterium, Quality of Life, Surveys and Questionnaires, Probiotics, Irritable Bowel Syndrome
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