The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention
Open accessAbstract
Summary: Background : Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear. Aim : To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms. Methods : A total of 103 patients fulfilling the Rome I or II criteria took part in this 6‐month, randomized, double‐blind placebo‐controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded. Results : At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: −13.9 to −1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non‐significant trend. Conclusions : The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Furthermore, two different multispecies probiotics have shown favourable effects on symptoms of IBS: a combination of two lactobacilli, one bifidobacteria and one propionic acid bacteria, 10 as well as a combination of eight strains, VSL#3. 11, 12”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“Most of the products provided daily doses in the range of 5-9 • 10 9 cfu and, in most cases, reductions in symptom severity score were observed [17][18][19][20][21] and some, but not all, of the products significantly reduced abdominal pain symptoms.”
From Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study (2009) · cites this paper as [19]
In the citing paper
“We have recently shown in a clinical trial that a multispecies probiotic significantly alleviates IBS symptoms, but the mechanisms behind the effects are not known. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“The results of this study are consistent with our previous findings concerning a similar multispecies probiotic. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
In the citing paper
“the two strains of B. breve included in the table were tested together with some of these bacteria [139,141] , or even with prebiotics such as galacto-oligosaccharides [140]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [139]
In the citing paper
“Specific probiotics help relieve overall symptom burden in some patients with IBS High [147,149,150,152,156-157,169, 174,176-178]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
In the citing paper
“Specific probiotics help reduce bloating/distension in some patients with IBS Moderate [147,149-150,155-156,168-170, 174-177,179-183]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
In the citing paper
“With specific probiotics, improvement of symptoms has been shown to lead to improvement in some aspects of health-related quality of life Moderate [147,150,152,155,169-170,174,176-177,179-180,183-184,186]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The rand 36‐item health survey 1.0
Hays, R. D., Sherbourne, C. D., & Mazel, R. M. (1993) · Health Economics · doi:10.1002/hec.4730020305 · Cited by 2,971
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Probiotics: A novel approach in the management of food allergy
Majamaa, H., & Isolauri, E. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70093-9 · Cited by 929
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699
Self-citationNobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E., & Spiegel, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.010 · Cited by 550
Safety of Probiotics That Contain Lactobacilli or Bifidobacteria
Borriello, S. P., Hammes, W. P., Holzapfel, W. H., Marteau, P. R., Schrezenmeir, J., Vaara, M., & Valtonen, V. (2003) · Clinical Infectious Diseases · doi:10.1086/368080 · Cited by 550
Törnblom, H., Lindberg, G., Nyberg, B., & Veress, B. (2002) · Gastroenterology · doi:10.1053/gast.2002.37059 · Cited by 516
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511
Niedzielin, K., Kordecki, H., & Birkenfeld, B. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200110000-00004 · Cited by 506
Viljanen, M., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00514.x · Cited by 478
Self-citationAbnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473
Kim, H. J., Camilleri, M., Mckinzie, S., Lempke, M. B., Burton, D. D., Thomforde, G. M., & Zinsmeister, A. R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01543.x · Cited by 468
Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy
Pohjavuori, E., Viljanen, M., Korpela, R., Kuitunen, M., Tiittanen, M., Vaarala, O., & Savilahti, E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.036 · Cited by 335
Self-citationEfficacy of Probiotic Use in Acute Diarrhea in Children: A Meta-Analysis
Huang, J. S., Bousvaros, A., Lee, J. W., Díaz, Á., & Davidson, E. J. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020501202369 · Cited by 321
Mättö, J., Maunuksela, L., Kajander, K., Palva, A., Korpela, R., Kassinen, A., & Saarela, M. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.08.009 · Cited by 301
Self-citationSen, S., Mullan, M. M., Parker, T. J., Woolner, J. T., Tarry, S. A., & Hunter, J. O. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020597001460 · Cited by 245
OʼSullivan, M. (2000) · Digestive and Liver Disease · doi:10.1016/s1590-8658(00)80021-3 · Cited by 245
Linskens, R. K., Huijsdens, X. W., Savelkoul, P. H. M., Vandenbroucke-Grauls, C. M. J. E., & Meuwissen, S. G. M. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655201753265082 · Cited by 233
Myllyluoma, E., Veijola, L., Ahlroos, T., Tynkkynen, S., Kankuri, E. M., Vapaatalo, H., Rautelin, H. I. K., & Korpela, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02448.x · Cited by 197
Self-citationBrigidi, P., Vitali, B., Swennen, E., Bazzocchi, G., & Matteuzzi, D. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01254-2 · Cited by 188
Ouwehand, A. C., Lagström, H., Suomalainen, T., & Salminen, S. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000063075 · Cited by 185
Verdú, E. F., Bercík, P., Bergonzelli, G. E., Huang, X.-X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.007 · Cited by 180
A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics
Madden, J. A. J., & Hunter, J. O. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002631 · Cited by 174
Viljanen, M., Kuitunen, M., Haahtela, T., Juntunen‐Backman, K., Korpela, R., & Savilahti, E. (2005) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00224.x · Cited by 172
Self-citationDesign of treatment trials for functional gastrointestinal disorders
van Zanten, S. J. O. V., Talley, N. J., Bytzer, P. M., Klein, K. B., Whorwell, P. J., & ZINSMEISTER, A. R. (1999) · Gut · doi:10.1136/gut.45.2008.ii69 · Cited by 155
Schultz, M., Linde, H., Lehn, N., Zimmermann, K., Grossmann, J., Falk, W., & Schölmerich, J. (2003) · Journal of Dairy Research · doi:10.1017/s0022029903006034 · Cited by 147
Treem, W. R., Ahsan, N., Kastoff, G., & Hyams, J. S. (1996) · Journal of Pediatric Gastroenterology & Nutrition · doi:10.1097/00005176-199610000-00013 · Cited by 146
Hillilä, M. T., & Färkkilä, M. A. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02034.x · Cited by 143
Self-citationBifidobacteria and lactobacilli in human health.
Orrhage, K., & Ce, N. (2000) · PubMed · Cited by 109
Propionic acid bacteria as protective cultures in fermented milks and breads
Suomalainen, T., & Mäyrä-Mäkinen, A. (1999) · Le Lait · doi:10.1051/lait:1999113 · Cited by 104
Antimicrobial Activity of 2-Pyrrolidone-5-Carboxylic Acid Produced by Lactic Acid Bacteria
Yang, Z., Suomalainen, T., Mäyrä-Mäkinen, A., & Huttunen, E. (1997) · Journal of Food Protection · doi:10.4315/0362-028x-60.7.786 · Cited by 51
The effects of probiotic bacteria on spontaneous contraction of isolated guinea-pig intestine
Massi, M., Ioan, P., Budriesi, R., Chiarini, A., Vitali, B., Brigidi, P., Lammers, K. M., Gionchetti, P., & Campieri, M. (2004) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · Cited by 4
Research works printed but not linked: 1
- Thompson WG, 1989, Irritable bowel syndrome: guidelines for the diagnosis, Gastroenterol Int, 2, 92
Cited by
Sorted by citations
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
Metadata
- Authors
- KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R.
- Affiliations
- University of Helsinki (FI)
- Valio (Finland) (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- KORPELA, R.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2005-08-26
- Volume
- 22
- Issue
- 5
- Pages
- 387-394
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2001065399
- Cited by
- 361
- References
- 37
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 25 · 2013: 23 · 2012: 30
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Valio
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, probiotics, Lactobacillus rhamnosus GG, abdominal pain, abdominal distension, flatulence, borborygmi, bowel habits, Rome criteria
- MeSH terms
- Adult, Aged, Defecation, Double-Blind Method, Female, Humans, Lactobacillus, Life Style, Male, Medical Records, Middle Aged, Propionibacterium, Quality of Life, Surveys and Questionnaires, Probiotics, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
