Applications of cyanobacteria in biotechnology
Abstract
Cyanobacteria have gained a lot of attention in recent years because of their potential applications in biotechnology. We present an overview of the literature describing the uses of cyanobacteria in industry and services sectors and provide an outlook on the challenges and future prospects of the field of cyanobacterial biotechnology. Cyanobacteria have been identified as a rich source of biologically active compounds with antiviral, antibacterial, antifungal and anticancer activities. Several strains of cyanobacteria were found to accumulate polyhydroxyalkanoates, which can be used as a substitute for nonbiodegradable petrochemical-based plastics. Recent studies showed that oil-polluted sites are rich in cyanobacterial consortia capable of degrading oil components. Cyanobacteria within these consortia facilitated the degradation processes by providing the associated oil-degrading bacteria with the necessary oxygen, organics and fixed nitrogen. Cyanobacterial hydrogen has been considered as a very promising source of alternative energy, and has now been made commercially available. In addition to these applications, cyanobacteria are also used in aquaculture, wastewater treatment, food, fertilizers, production of secondary metabolites including exopolysaccharides, vitamins, toxins, enzymes and pharmaceuticals. Future research should focus on isolating new cyanobacterial strains producing high value products and genetically modifying existing strains to ensure maximum production of the desired products. Metagenomic libraries should be constructed to discover new functional genes that are involved in the biosynthesis of biotechnological relevant compounds. Large-scale industrial production of the cyanobacterial products requires optimization of incubation conditions and fermenter designs in order to increase productivity.
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At least 14 genera of cyanobacteria are capable of producing H2.
“Several reports have reviewed cyanobacterial species capable of producing H2 (Abed et al. 2009; Das and Veziroglu 2001; Dutta et al. 2005) including at least 14 genera cultivated under different growth conditions.”
From Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering (2011) · cites this paper as Abed et al. 2009
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A Low-Pressure, N2/CO2 Atmosphere Is Suitable for Cyanobacterium-Based Life-Support Systems on Mars
Verseux, C., Heinicke, C., Ramalho, T. P., Determann, J., Duckhorn, M., Smagin, M., & Avila, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.611798 · Cited by 72 · see citing works
Versatile Applications of Cyanobacteria in Biotechnology
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022) · Microorganisms · doi:10.3390/microorganisms10122318 · Cited by 64 · see citing works
Cyanobacteria as Photosynthetic Biocatalysts: A Systems Biology Perspective
Gudmundsson, S., & Nogales, J. (2014) · Molecular BioSystems · doi:10.1039/c4mb00335g · Cited by 61 · see citing works
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Till, P., Toepel, J., Bühler, B., Mach, R. L., & Mach-Aigner, A. R. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10344-w · Cited by 54 · see citing works
Rastogi, R. P., Madamwar, D., & Incharoensakdi, A. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12879 · Cited by 55 · see citing works
Stucken, K., Koch, R., & Dagan, T. (2013) · Biological Research · doi:10.4067/s0716-97602013000400009 · Cited by 52 · see citing works
Design of Closed Photobioreactors for Algal Cultivation
Koller, M. (2015) · Algal Biorefineries · doi:10.1007/978-3-319-20200-6_4 · Cited by 66 · see citing works
Regulation of antioxidant defense and glyoxalase systems in cyanobacteria
Rai, R., Singh, S., Rai, K. K., Raj, A., Sriwastaw, S., & Rai, L. C. (2021) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2021.09.037 · Cited by 51 · see citing works
Cyanotherapeutics: An emerging field for future drug discovery
Tiwari, A. K., & Tiwari, B. S. (2020) · Applied Phycology · doi:10.1080/26388081.2020.1744480 · Cited by 49 · see citing works
Polymer accumulation in mixed cyanobacterial cultures selected under the feast and famine strategy
Arias, D. M., Fradinho, J. C., Uggetti, E., García, J., Oehmen, A., & Reis, M. A. M. (2018) · Algal Research · doi:10.1016/j.algal.2018.04.027 · Cited by 38 · see citing works
Purdy, H. M., Pfleger, B. F., & Reed, J. L. (2022) · Metabolic Engineering · doi:10.1016/j.ymben.2021.11.003 · Cited by 18 · see citing works
Current advances in CRISPR-Cas-mediated gene editing and regulation in cyanobacteria
Dong, Z., Chen, L., Wang, Y., Sun, T., & Zhang, W. (2024) · Blue Biotechnology · doi:10.1186/s44315-024-00009-3 · Cited by 16 · see citing works
Sukhinov, D. V., Gotovtsev, P. M., & Sergeeva, Y. E. (2023) · Acta Astronautica · doi:10.1016/j.actaastro.2023.07.006 · Cited by 11 · see citing works
- Authors
- Abed, R. M. M., Dobretsov, S., & Sudesh, K.
- Affiliations
- Sultan Qaboos University (OM)
- Universiti Sains Malaysia (MY)
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 106
- Issue
- 1
- Pages
- 1-12
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W1992433658
- Cited by
- 528
- References
- 102
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 48 · 2023: 37 · 2022: 41 · 2021: 45 · 2020: 66 · 2019: 36 · 2018: 44 · 2017: 38 · 2016: 23 · 2015: 24 · 2014: 25 · 2013: 22 · 2012: 21
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
- Keywords
- cyanobacteria, cyanobacterial biotechnology, bioactive compounds, polyhydroxyalkanoates, biodegradable plastics, aquaculture, wastewater treatment, secondary metabolites, exopolysaccharides, cyanotoxins, metagenomics
- MeSH terms
- Cyanobacteria, Biocompatible Materials, Biodegradation, Environmental, Biotechnology, Fertilizers, Hydrogen, Industrial Microbiology, Oils, Plastics
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