The Bed Nucleus Is a Neuroanatomical Substrate for the Anorectic Effect of Corticotropin-Releasing Factor and for Its Reversal by Nociceptin/Orphanin FQ
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Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid N/OFQ receptor (NOP), possesses marked functional anti-stress and anti-corticotropin-releasing factor (CRF) actions. We have shown that intracerebroventricular injection of N/OFQ reverses the hypophagic effect induced by stress or by CRF given intracerebroventricularly. To shed new light on the mechanisms involved in the anti-CRF action of N/OFQ, we investigated the ability of N/OFQ to prevent CRF-induced anorexia after microinjection studies into brain areas of potential interest in the control of feeding behavior and coexpressing NOP and CRF receptors. These areas include the bed nucleus of the stria terminalis (BNST), the central amygdala (CeA), the locus ceruleus (LC), the ventromedial hypothalamus (VMH), the paraventricular nucleus (PVN), and the dorsal raphe (DR). The results demonstrated that the anorectic effect of 0.04 nmol of CRF per rat (200 ng per rat) given intracerebroventricularly is reversed by pretreatment with 0.01-0.21 nmol of N/OFQ per rat (25-500 ng per rat) injected into the BNST but not into the CeA, LC, VMH, PVN, or DR. Microinjection of 0.01-0.02 nmol of CRF per site (50-100 ng per site) into the BNST but not into the CeA or the LC induced marked anorexia in food-deprived rats. Pretreatment with 0.01-0.21 nmol of N/OFQ per site (25-500 ng per site) into the BNST also blocked the anorectic action of 0.02 nmol of CRF per site (100 ng per site) given in the same area. Finally, intra-BNST microinjection of 0.01-0.21 nmol of N/OFQ per site (25-500 ng per site) did not modify food intake in either food-sated or food-deprived rats. These data demonstrate that the BNST is involved in the modulation of CRF-induced anorexia, which is prevented by activation of N/OFQ receptors.
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Intra-bed nucleus of the stria terminalis CRF infusions have anorectic effects that were not associated with intra-central amygdala CRF infusions.
“to have anorectic effects which, in the same study, were not associated with intra-CeA CRF infusions (Ciccocioppo et al, 2003).”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Ciccocioppo et al, 2003
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Self-citationInputs to the ventrolateral bed nucleus of the stria terminalis
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- Authors
- Ciccocioppo, R., Fedeli, A., Economidou, D., Policani, F., Weiss, F., & Massi, M.
- Affiliations
- Università di Camerino (IT)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-15
- Volume
- 23
- Issue
- 28
- Pages
- 9445-9451
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3035815
- OpenAlex
- W2156466346
- Cited by
- 137
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 11 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- National Institutes of Health
- U.S. Public Health Service (10531)
- National Institute on Alcohol Abuse and Alcoholism (R01AA010531)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- nociceptin/orphanin FQ, corticotropin-releasing factor, bed nucleus of the stria terminalis, anorexia, feeding behavior, CRF receptors, stress, food deprivation, central amygdala, locus coeruleus, ventromedial hypothalamus, paraventricular nucleus, dorsal raphe nucleus, neuroanatomical substrates
- MeSH terms
- Nociceptin, Amygdala, Animals, Anorexia, Appetite Depressants, Corticotropin-Releasing Hormone, Drug Administration Routes, Eating, Locus Coeruleus, Male, Microinjections, Paraventricular Hypothalamic Nucleus, Raphe Nuclei, Septal Nuclei, Ventromedial Hypothalamic Nucleus, Rats, Wistar, Opioid Peptides, Rats
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