Cited by 55Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

α‐Melanocyte‐Stimulating Hormone and Oxytocin: A Peptide Signalling Cascade in the Hypothalamus

Sabatier, N.·2006·Journal of Neuroendocrinology

Abstract

alpha-Melanocyte-stimulating hormone (alpha-MSH) and oxytocin share remarkable similarities of effects on behaviour in rats; in particular, they both inhibit feeding behaviour and stimulate sexual behaviour. Recently, we showed that alpha-MSH interacts with the magnocellular oxytocin system in the supraoptic nucleus; alpha-MSH induces the release of oxytocin from the dendrites of magnocellular neurones but it inhibits the secretion of oxytocin from their nerve terminals in the posterior pituitary. This effect of alpha-MSH on supraoptic nucleus oxytocin neurones is remarkable for two reasons. First, it illustrates the capacity of magnocellular neurones to differentially regulate peptide release from dendrites and axons and, second, it emphasises the putative role of magnocellular neurones as a major source of central oxytocin release, and as a likely substrate of some oxytocin-mediated behaviours. The ability of peptides to differentially control secretion from different compartments of their targets indicates one way by which peptide signals might have a particularly significant effect on neuronal circuitry. This suggests a possible explanation for the striking way in which some peptides can influence specific, complex behaviours.

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Crossref · 10.1111/j.1365-2826.2006.01464.x

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Authors
Sabatier, N.
Affiliations
University of Edinburgh (GB)
Corresponding author
Sabatier, N.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2006-07-28
Volume
18
Issue
9
Pages
703-710
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W1984196394
Cited by
54
References
68
Citations by year
2024: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Merck
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
alpha-melanocyte-stimulating hormone, oxytocin, hypothalamus, supraoptic nucleus, magnocellular neurons, feeding behaviour, sexual behavior, neurohypophysis
MeSH terms
alpha-MSH, Animals, Feeding Behavior, Humans, Hypothalamus, Oxytocin, Sexual Behavior, Sexual Behavior, Animal, Signal Transduction, Rats

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