α‐Melanocyte‐Stimulating Hormone and Oxytocin: A Peptide Signalling Cascade in the Hypothalamus
Abstract
alpha-Melanocyte-stimulating hormone (alpha-MSH) and oxytocin share remarkable similarities of effects on behaviour in rats; in particular, they both inhibit feeding behaviour and stimulate sexual behaviour. Recently, we showed that alpha-MSH interacts with the magnocellular oxytocin system in the supraoptic nucleus; alpha-MSH induces the release of oxytocin from the dendrites of magnocellular neurones but it inhibits the secretion of oxytocin from their nerve terminals in the posterior pituitary. This effect of alpha-MSH on supraoptic nucleus oxytocin neurones is remarkable for two reasons. First, it illustrates the capacity of magnocellular neurones to differentially regulate peptide release from dendrites and axons and, second, it emphasises the putative role of magnocellular neurones as a major source of central oxytocin release, and as a likely substrate of some oxytocin-mediated behaviours. The ability of peptides to differentially control secretion from different compartments of their targets indicates one way by which peptide signals might have a particularly significant effect on neuronal circuitry. This suggests a possible explanation for the striking way in which some peptides can influence specific, complex behaviours.
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α-MSH acts on melanocortin 4 receptors to induce non-synaptic release of OT but not AVP from hypothalamic neurons.
“α-MSH acts on melanocortin 4 receptors to induce non-synaptic release of OT but not AVP from hypothalamic neurons [118; 119].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [119]
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- Authors
- Sabatier, N.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Sabatier, N.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2006-07-28
- Volume
- 18
- Issue
- 9
- Pages
- 703-710
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1984196394
- Cited by
- 54
- References
- 68
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Merck
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- alpha-melanocyte-stimulating hormone, oxytocin, hypothalamus, supraoptic nucleus, magnocellular neurons, feeding behaviour, sexual behavior, neurohypophysis
- MeSH terms
- alpha-MSH, Animals, Feeding Behavior, Humans, Hypothalamus, Oxytocin, Sexual Behavior, Sexual Behavior, Animal, Signal Transduction, Rats
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