Cited by 112Neuroendocrine regulation and behaviorRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

Oxytocin and appetite

LENG, G, ONAKA, T, CAQUINEAU, C, SABATIER, N, TOBIN, V, TAKAYANAGI, Y·2008·Progress in brain research

Abstract

Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.

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Crossref · 10.1016/s0079-6123(08)00413-5

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  • Oxytocin regulates feeding and metabolism at several sites, and its receptors are present throughout the gastrointestinal tract and on gastric vagal nerve endings.

    “Oxytocin regulates feeding and metabolism at multiple sites (34,35).Its receptors are expressed throughout the gastrointestinal tract, and on gastric vagal nerve endings (36).”

    From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [35]

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Authors
LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
Affiliations
Jichi Medical University (JP)
Corresponding author
LENG, G
Venue
Progress in brain research
Publisher
Elsevier
Published
2008
Volume
170
Pages
137-151
ISSN
0079-6123 (ISSN-L)
OpenAlex
W1884119423
Cited by
112
References
114
Citations by year
2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
FWCI
13.33
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal Society of Edinburgh
  • Biotechnology and Biological Sciences Research Council (BB/E015123/1)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
MeSH terms
Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction

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