Oxytocin and appetite
Abstract
Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.
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Oxytocin regulates feeding and metabolism at several sites, and its receptors are present throughout the gastrointestinal tract and on gastric vagal nerve endings.
“Oxytocin regulates feeding and metabolism at multiple sites (34,35).Its receptors are expressed throughout the gastrointestinal tract, and on gastric vagal nerve endings (36).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [35]
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- Authors
- LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
- Affiliations
- Jichi Medical University (JP)
- Corresponding author
- LENG, G
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 137-151
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1884119423
- Cited by
- 112
- References
- 114
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 13.33
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society of Edinburgh
- Biotechnology and Biological Sciences Research Council (BB/E015123/1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
- MeSH terms
- Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction
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