Cited by 178Gastrointestinal motility and disordersConnective tissue disorders researchGastroesophageal reflux and treatments

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link?

zarate, n., farmer, a. d., grahame, r., mohammed, s. d., knowles, c. h., scott, s. m., aziz, q.·2010·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2009.01421.x

Open this paper in CoChat — free account

Abstract

BACKGROUND Unexplained gastrointestinal (GI) symptoms and joint hypermobility (JHM) are common in the general population, the latter described as benign joint hypermobility syndrome (BJHS) when associated with musculo-skeletal symptoms. Despite overlapping clinical features, the prevalence of JHM or BJHS in patients with functional gastrointestinal disorders has not been examined. METHODS The incidence of JHM was evaluated in 129 new unselected tertiary referrals (97 female, age range 16-78 years) to a neurogastroenterology clinic using a validated 5-point questionnaire. A rheumatologist further evaluated 25 patients with JHM to determine the presence of BJHS. Groups with or without JHM were compared for presentation, symptoms and outcomes of relevant functional GI tests. KEY RESULTS Sixty-three (49%) patients had evidence of generalized JHM. An unknown aetiology for GI symptoms was significantly more frequent in patients with JHM than in those without (P < 0.0001). The rheumatologist confirmed the clinical impression of JHM in 23 of 25 patients, 17 (68%) of whom were diagnosed with BJHS. Patients with co-existent BJHS and GI symptoms experienced abdominal pain (81%), bloating (57%), nausea (57%), reflux symptoms (48%), vomiting (43%), constipation (38%) and diarrhoea (14%). Twelve of 17 patients presenting with upper GI symptoms had delayed gastric emptying. One case is described in detail. CONCLUSIONS & INFERENCES In a preliminary retrospective study, we have found a high incidence of JHM in patients referred to tertiary neurogastroenterology care with unexplained GI symptoms and in a proportion of these a diagnosis of BJHS is made. Symptoms and functional tests suggest GI dysmotility in a number of these patients. The possibility that a proportion of patients with unexplained GI symptoms and JHM may share a common pathophysiological disorder of connective tissue warrants further investigation.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2982.2009.01421.x

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ROME III: The Functional Gastrointestinal Disorders
Sheth, A. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31804bbe26 · Cited by 1,974
Articular mobility in an African population.
Beighton, P., Solomon, L., & Soskolne, C. L. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.413 · Cited by 1,727
Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine
Abell, T. L., Camilleri, M., Donohoe, K., Hasler, W. L., Lin, H. C., Maurer, A. H., McCallum, R. W., Nowak, T., Nusynowitz, M. L., Parkman, H. P., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01636.x · Cited by 786
Untitled work
(2000) · PubMed · Cited by 738
Self-citation
Demography, Clinical Characteristics, Psychological and Abuse Profiles, Treatment, and Long-Term Follow-up of Patients with Gastroparesis
Soykan, I., Sivri, B., Sarosiek, I., Kiernan, B., & Mccallum, R. W. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1026665728213 · Cited by 575
Untitled work
(2006) · Cited by 534
Dysautonomia in the joint hypermobility syndrome
Gazit, Y., Nahir, A. M., Grahame, R., & Jacob, G. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00235-3 · Cited by 390
Self-citation
Mechanisms of hypersensitivity in IBS and functional disorders
Azpiroz, F., Bouin, M., Camilleri, M., Mayer, E. A., Poitras, P., Serra, J., & Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00875.x · Cited by 367
Untitled work
(2007) · PubMed · Cited by 356
Review article: epidemiology and quality of life in functional gastrointestinal disorders
Chang, L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02183.x · Cited by 352

Show all 50 references

Sorted by citations

A framework for the classification of joint hypermobility and related conditions
Castori, M., Tinkle, B., Levy, H., Grahame, R., Malfait, F., & Hakim, A. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31539 · Cited by 602
Self-citation
Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history
Tinkle, B., Castori, M., Berglund, B., Cohen, H., Grahame, R., Kazkaz, H., & Levy, H. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31538 · Cited by 499
Self-citation
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number
Lyons, J. J., Yu, X., Hughes, J. D., Le, Q. T., Jamil, A., Bai, Y., Ho, N., Zhao, M., Liu, Y., O'Connell, M. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3696 · Cited by 394
Postural tachycardia syndrome—current experience and concepts
Mathias, C. J., Low, D. A., Iodice, V., Owens, A. P., Kirbis, M., & Grahame, R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.187 · Cited by 251
Self-citation
Natural history and manifestations of the hypermobility type Ehlers–Danlos syndrome: A pilot study on 21 patients
Castori, M., Camerota, F., Celletti, C., Danese, C., Santilli, V., Saraceni, V. M., & Grammatico, P. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33231 · Cited by 228
Ehlers-Danlos Syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder with mucocutaneous, articular, and systemic manifestations
Castori, M. (2012) · ISRN Dermatology · doi:10.5402/2012/751768 · Cited by 222
Pain management in the Ehlers–Danlos syndromes
Chopra, P., Tinkle, B., Hamonet, C., Brock, I., Gompel, A., Bulbena, A., & Francomano, C. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31554 · Cited by 209
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome
Engelbert, R. H. H., Juul‐Kristensen, B., Pacey, V., de Wandele, I., Smeenk, S., Woinarosky, N., Sabo, S., Scheper, M. C., Russek, L., & Simmonds, J. V. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31545 · Cited by 177
Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic
Nelson, A. D., Mouchli, M. A., Valentin, N., Deyle, D., Pichurin, P., Acosta, A., & Camilleri, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12665 · Cited by 182
Gastrointestinal involvement in the Ehlers–Danlos syndromes
Fikree, A., Chelimsky, G., Collins, H., Kovacic, K., & Aziz, Q. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31546 · Cited by 159
Self-citation
Re‐writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type
Castori, M., Morlino, S., Celletti, C., Ghibellini, G., Bruschini, M., Grammatico, P., Blundo, C., & Camerota, F. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36315 · Cited by 159
Joint Hypermobility Syndrome: Recognizing a Commonly Overlooked Cause of Chronic Pain
Kumar, B., & Lenert, P. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.02.013 · Cited by 153
Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers–Danlos syndrome, hypermobility type): Principles and proposal for a multidisciplinary approach
Castori, M., Morlino, S., Celletti, C., Celli, M., Morrone, A., Colombi, M., Camerota, F., & Grammatico, P. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35483 · Cited by 162
Hypermobile Ehlers‐Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes
Gensemer, C., Burks, R., Kautz, S. A., Judge, D. P., Lavallee, M. E., & Norris, R. A. (2020) · Developmental Dynamics · doi:10.1002/dvdy.220 · Cited by 162
Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome
Roma, M., Marden, C. L., De Wandele, I., Francomano, C. A., & Rowe, P. C. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.02.006 · Cited by 133
Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers‐danlos syndrome hypermobility type compared to other heritable connective tissue disorders
Colombi, M., Dordoni, C., Chiarelli, N., & Ritelli, M. (2015) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31429 · Cited by 127
Medication, surgery, and physiotherapy among patients with the hypermobility type of Ehlers-Danlos syndrome
Rombaut, L., Malfait, F., De Wandele, I., Cools, A., Thijs, Y., De Paepe, A., & Calders, P. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.01.016 · Cited by 124
Autonomic symptom burden in the hypermobility type of Ehlers–Danlos syndrome: A comparative study with two other EDS types, fibromyalgia, and healthy controls
De Wandele, I., Calders, P., Peersman, W., Rimbaut, S., De Backer, T., Malfait, F., De Paepe, A., & Rombaut, L. (2014) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2014.05.013 · Cited by 119
Functional gastrointestinal disorders are associated with the joint hypermobility syndrome in secondary care: a case–control study
Fikree, A., Aktar, R., Grahame, R., Hakim, A. J., Morris, J. K., Knowles, C. H., & Aziz, Q. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12535 · Cited by 117
Self-citation
Joint hypermobility syndrome
ROSS, J. L., & Grahame, R. (2011) · BMJ · doi:10.1136/bmj.c7167 · Cited by 108
Self-citation
Contemporary approach to joint hypermobility and related disorders
Castori, M., & Hakim, A. (2017) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000541 · Cited by 105
A Prospective Evaluation of Undiagnosed Joint Hypermobility Syndrome in Patients With Gastrointestinal Symptoms
Fikree, A., Grahame, R., Aktar, R., Farmer, A. D., Hakim, A. J., Morris, J. K., Knowles, C. H., & Aziz, Q. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.01.014 · Cited by 104
Self-citation
Need for a consensus on the methods by which to measure joint mobility and the definition of norms for hypermobility that reflect age, gender and ethnic-dependent variation: is revision of criteria for joint hypermobility syndrome and Ehlers-Danlos syndrome hypermobility type indicated?
Remvig, L., Engelbert, R. H., Berglund, B., Bulbena, A., Byers, P. H., Grahame, R., Juul-Kristensen, B., Lindgren, K.-A., Uitto, J., & Wekre, L. L. (2011) · Rheumatology · doi:10.1093/rheumatology/ker140 · Cited by 99
Self-citation
Gastrointestinal and nutritional issues in joint hypermobility syndrome/ehlers–danlos syndrome, hypermobility type
Castori, M., Morlino, S., Pascolini, G., Blundo, C., & Grammatico, P. (2015) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31431 · Cited by 98
Symptom and joint mobility progression in the joint hypermobility syndrome (Ehlers-Danlos syndrome, hypermobility type).
(2011) · PubMed · Cited by 91
Gastrointestinal disorders in joint hypermobility syndrome/Ehlers‐Danlos syndrome hypermobility type: A review for the gastroenterologist
Beckers, A. B., Keszthelyi, D., Fikree, A., Vork, L., Masclee, A., Farmer, A. D., & Aziz, Q. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13013 · Cited by 90
Self-citation
Joint hypermobility syndrome pain
Grahame, R. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0070-5 · Cited by 88
Self-citation
Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type
Chiarelli, N., Carini, G., Zoppi, N., Dordoni, C., Ritelli, M., Venturini, M., Castori, M., & Colombi, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161347 · Cited by 78
Joint hypermobility and rectal evacuatory dysfunction: an etiological link in abnormal connective tissue?: Rectal evacuatory dysfunction and joint hypermobility
Mohammed, S. D., Lunniss, P. J., Zarate, N., Farmer, A. D., Grahame, R., Aziz, Q., & Scott, S. M. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01562.x · Cited by 70
Self-citation
Rome IV Functional Gastrointestinal Disorders and Health Impairment in Subjects With Hypermobility Spectrum Disorders or Hypermobile Ehlers-Danlos Syndrome
Lam, C. Y., Palsson, O. S., Whitehead, W. E., Sperber, A. D., Tornblom, H., Simren, M., & Aziz, I. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.02.034 · Cited by 71
Joint Hypermobility: A Common Association with Complex Functional Gastrointestinal Disorders
Kovacic, K., Chelimsky, T. C., Sood, M. R., Simpson, P., Nugent, M., & Chelimsky, G. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.07.021 · Cited by 67
Joint Hypermobility Syndrome
Fikree, A., Aziz, Q., & Grahame, R. (2013) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2013.03.003 · Cited by 63
Self-citation
Hypermobility and Dance: A Review
Day, H., Koutedakis, Y., & Wyon, M. A. (2011) · International Journal of Sports Medicine · doi:10.1055/s-0031-1273690 · Cited by 65
Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know
Thwaites, P. A., Gibson, P. R., & Burgell, R. E. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15927 · Cited by 59
Exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome/Ehlers–Danlos syndrome – hypermobility type
Simmonds, J. V., Herbland, A., Hakim, A., Ninis, N., Lever, W., Aziz, Q., & Cairns, M. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1398278 · Cited by 60
Self-citation
Gastrointestinal Manifestations of Rheumatological Diseases
Kröner, P. T., Tolaymat, O., Bowman, A. W., Abril, A., & Lacy, B. E. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000260 · Cited by 59
Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review
Mehr, S. E., Barbul, A., & Shibao, C. A. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0519-x · Cited by 55
Neurodevelopmental attributes of joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type: Update and perspectives
Ghibellini, G., Brancati, F., & Castori, M. (2015) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31424 · Cited by 53
Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience
Alomari, M., Hitawala, A., Chadalavada, P., Covut, F., Al Momani, L., Khazaaleh, S., Gosai, F., Al Ashi, S., Abushahin, A., & Schneider, A. (2020) · Cureus · doi:10.7759/cureus.7881 · Cited by 53
“A few theories that have been put forward as possible mechanisms behind the intestinal dysmotility in EDS and those include autonomic neuropathy, mixed enteric neuro-myopathy, and alterations in the composition of the extracellular matrix in which the other components of the gut wall are embedded [11].”
Background
The intersect of gastrointestinal symptoms and malnutrition associated with anorexia nervosa and avoidant/restrictive food intake disorder: Functional or pathophysiologic?—A systematic review
Gibson, D., Watters, A., & Mehler, P. S. (2021) · International Journal of Eating Disorders · doi:10.1002/eat.23553 · Cited by 50
Review article: the assessment and management of chronic severe gastrointestinal dysmotility in adults
Paine, P., McLaughlin, J. T., & Lal, S. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12496 · Cited by 51
Pain in Ehlers-Danlos syndromes: manifestations, therapeutic strategies and future perspectives
Castori, M. (2016) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2016.1238302 · Cited by 46
A study exploring the prevalence of Joint Hypermobility Syndrome in patients attending a Musculoskeletal Triage Clinic
Connelly, E., Hakim, A. J., Davenport, S., & Simmonds, J. V. (2015) · Physiotherapy Practice and Research · doi:10.3233/ppr-140046 · Cited by 46
Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel Disease
Vounotrypidis, P., Efremidou, E., Zezos, P., Pitiakoudis, M., Maltezos, E., Lyratzopoulos, N., & Kouklakis, G. (2009) · Gastroenterology Research and Practice · doi:10.1155/2009/924138 · Cited by 44
Difficulty eating and significant weight loss in joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type
Baeza-Velasco, C., Van den Bossche, T., Grossin, D., & Hamonet, C. (2016) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-015-0232-x · Cited by 39
Screening for celiac disease in the joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type
Danese, C., Castori, M., Celletti, C., Amato, S., Lo Russo, C., Grammatico, P., & Camerota, F. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34134 · Cited by 38
Postural tachycardia in hypermobile Ehlers-Danlos syndrome: A distinct subtype?
Miglis, M. G., Schultz, B., & Muppidi, S. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.10.001 · Cited by 38
Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults
O’Dwyer, R. H., Acosta, A. J., Camilleri, M., Burton, D. B., Busciglio, I. A., & Bharucha, A. E. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3645-5 · Cited by 36
Mechanisms of visceral pain in health and functional gastrointestinal disorders
Farmer, A. D., & Aziz, Q. (2014) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2014.01.002 · Cited by 38
Self-citation
Neurovisceral phenotypes in the expression of psychiatric symptoms
Eccles, J., Owens, A. P., Mathias, C. J., Umeda, S., & Critchley, H. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00004 · Cited by 37
Abnormal gastric myoelectrical activity in postural tachycardia syndrome
Seligman, W. H., Low, D. A., Asahina, M., & Mathias, C. J. (2013) · Clinical Autonomic Research · doi:10.1007/s10286-012-0185-3 · Cited by 33
Joint Hypermobility and Headache: Understanding the Glue That Binds the Two Together – Part 1
Neilson, D., & Martin, V. T. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12418 · Cited by 32
Cardiac autonomic regulation and joint hypermobility in adolescents with functional abdominal pain disorders.
Kolacz, J., Kovacic, K., Lewis, G. F., Sood, M. R., Aziz, Q., Roath, O. R., & Porges, S. W. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14165 · Cited by 30
Self-citation
Ehlers–Danlos syndrome(s) mimicking child abuse: Is there an impact on clinical practice?
Castori, M. (2015) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31460 · Cited by 30
Diverticulosis and nine connective tissue disorders: epidemiological support for an association
Broad, J., Wu, Z., Clark, T. G., Musson, D. S., Jaung, R., Arroll, B., Bissett, I. P., & Connolly, M. J. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1570169 · Cited by 30
Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review
Doolan, B. J., Lavallee, M. E., Haußer, I., Schubart, J. R., Pope, F. M., Seneviratne, S. L., Winship, I., & Burrows, N. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1053466 · Cited by 32
Higher prevalence of joint hypermobility in constipation predominant irritable bowel syndrome
Zweig, A., Schindler, V., Becker, A. S., van Maren, A., & Pohl, D. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13353 · Cited by 29
Refining patterns of joint hypermobility, habitus, and orthopedic traits in joint hypermobility syndrome and Ehlers–Danlos syndrome, hypermobility type
Morlino, S., Dordoni, C., Sperduti, I., Venturini, M., Celletti, C., Camerota, F., Colombi, M., & Castori, M. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38106 · Cited by 29
Mechanisms underlying reflux symptoms and dysphagia in patients with joint hypermobility syndrome, with and without postural tachycardia syndrome
Fikree, A., Aziz, Q., & Sifrim, D. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13029 · Cited by 30
Self-citation
Prevalence of Functional GI Diseases and Pelvic Floor Symptoms in Marfan Syndrome and Ehlers-Danlos Syndrome: A National Cohort Study
Nee, J., Kilaru, S., Kelley, J., Oza, S. S., Hirsch, W., Ballou, S., Lembo, A., & Wolf, J. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001173 · Cited by 29
Prevalence of gastrointestinal, cardiovascular, autonomic and allergic manifestations in hospitalized patients with Ehlers-Danlos syndrome: a case-control study
Brooks, R. S., Grady, J., Lowder, T. W., & Blitshteyn, S. (2021) · Rheumatology · doi:10.1093/rheumatology/keaa926 · Cited by 28
Chronic widespread pain and neurophysiological symptoms in joint hypermobility syndrome (JHS)
Clark, C., Khattab, A., & Carr, E. (2014) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2014.21.2.60 · Cited by 28
Extraintestinal Manifestations in Children With Gastrointestinal Food Allergy
Domínguez‐Ortega, G., Borrelli, O., Meyer, R. W., Dziubak, R., Koker, C. D., Godwin, H., Fleming, C., Thapar, N., Elawad, M., Kiparissi, F., et al. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000391 · Cited by 27
Spectrum of gastrointestinal manifestations in joint hypermobility syndromes
Botrus, G., Baker, O., Borrego, E., Ngamdu, K. S., Teleb, M., Gonzales Martinez, J. L., Maldonado, G., Hussein, A. M., & McCallum, R. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.03.001 · Cited by 26
A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers‐Danlos Syndrome‐Hypermobility Type: A feasibility study
Menys, A., Keszthelyi, D., Fitzke, H., Fikree, A., Atkinson, D., Aziz, Q., & Taylor, S. A. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13090 · Cited by 26
Self-citation
Gastrointestinal and eating problems in women with Ehlers–Danlos syndromes
Baeza-Velasco, C., Lorente, S., Tasa-Vinyals, E., Guillaume, S., Mora, M. S., & Espinoza, P. (2021) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-021-01146-z · Cited by 25
Irritable Bowel Syndrome-Like Symptoms in Quiescent Inflammatory Bowel Disease: A Practical Approach to Diagnosis and Treatment of Organic Causes
Lim, J. E., & Rezaie, A. R. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08095-w · Cited by 27
Nationwide population-based cohort study of celiac disease and risk of Ehlers-Danlos syndrome and joint hypermobility syndrome
Laszkowska, M., Roy, A., Lebwohl, B., Green, P. H. R., Sundelin, H. E. K., & Ludvigsson, J. F. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.05.019 · Cited by 24
Other Forms of Gastroparesis
Quigley, E. M. M. (2014) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2014.11.006 · Cited by 24
An Approach to the Patient With Chronic Undiagnosed Abdominal Pain
Pichetshote, N., & Pimentel, M. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000130 · Cited by 25
Arachnodactyly—a key to diagnosing heritable disorders of connective tissue
Grahame, R., & Hakim, A. J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.24 · Cited by 24
Self-citation
Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management
Lam, C., Amarasinghe, G., Zarate-Lopez, N., Fikree, A., Byrne, P., Kiani-Alikhan, S., Gabe, S., & Paine, P. (2023) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102088 · Cited by 23
Subtle differences in autonomic symptoms in people diagnosed with hypermobile Ehlers–Danlos syndrome and hypermobility spectrum disorders
Martinez, K. L., Mauss, C., Andrews, J., Saboda, K., Huynh, J. M., Sanoja, A. J., Jesudas, R., Byers, P. H., & Laukaitis, C. M. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62197 · Cited by 25
Gastrointestinal Symptoms in Marfan Syndrome and Hypermobile Ehlers-Danlos Syndrome
Inayet, N., Hayat, J. O., Kaul, A., Tome, M., Child, A., & Poullis, A. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/4854701 · Cited by 23
Ehlers–Danlos syndrome in a young woman with anorexia nervosa and complex somatic symptoms
Lee, M., & Strand, M. (2017) · International Journal of Eating Disorders · doi:10.1002/eat.22815 · Cited by 23
Ehlers–Danlos syndrome hypermobility type: a possible unifying concept for various functional somatic syndromes
Castori, M., Celletti, C., & Camerota, F. (2011) · Rheumatology International · doi:10.1007/s00296-011-2275-2 · Cited by 22
Disordered eating among adolescents with chronic pain: the experience of a pediatric rheumatology subspecialty pain clinic
Pianucci, L., Sonagra, M., Greenberg, B. A., Priestley, D. R., & Gmuca, S. (2021) · Pediatric Rheumatology · doi:10.1186/s12969-021-00506-4 · Cited by 20
Biomarkers for Ehlers-Danlos Syndromes: There Is a Role?
Caliogna, L., Guerrieri, V., Annunziata, S., Bina, V., Brancato, A. M., Castelli, A., Jannelli, E., Ivone, A., Grassi, F. A., Mosconi, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810149 · Cited by 21
Functional Abdominal Pain in Childhood: Background Studies and Recent Research Trends
Levy, R. L., & van Tilburg, M. A. L. (2012) · Pain Research and Management · doi:10.1155/2012/960104 · Cited by 22
Joint hypermobility: emerging disease or illness behaviour?
Grahame, R. (2013) · Clinical Medicine · doi:10.7861/clinmedicine.13-6-s50 · Cited by 21
Self-citation
Children with Functional Nausea—Comorbidities outside the Gastrointestinal Tract
Tarbell, S. E., Sullivan, E. C., Meegan, C., & Fortunato, J. E. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.04.019 · Cited by 19
Rectal hyposensitivity: a common pathophysiological finding in patients with constipation and associated hypermobile Ehlers–Danlos syndrome
Choudhary, A., Vollebregt, P. F., Aziz, Q., Scott, S. M., & Fikree, A. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17104 · Cited by 18
Self-citation
Functional Gastrointestinal Disorders and Joint Hypermobility: A School‐based Study
Saps, M., Blom, P. J. J., Velasco‐Benitez, C. A., & Benninga, M. A. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001724 · Cited by 19
Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes
Do, T., Diamond, S. J., Green, C., & Warren, M. M. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00373-1 · Cited by 19
Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health
Csecs, J. L. L., Dowell, N. G., Savage, G. K., Iodice, V., Mathias, C. J., Critchley, H., & Eccles, J. (2021) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31957 · Cited by 18
Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome
Spiegel, B. M. R. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002066 · Cited by 19
Joint hypermobility syndrome (a.k.a. Ehlers-Danlos Syndrome, Hypermobility Type): an updated critique.
Castori, M. (2013) · PubMed · Cited by 18
Managing gastrointestinal challenges: Diarrhea in sickle cell anemia
Obeagu, E. I., & Obeagu, G. U. (2024) · Medicine · doi:10.1097/md.0000000000038075 · Cited by 17
Joint Hypermobility Syndrome in Patients With Functional Dyspepsia
Carbone, F., Fikree, A., Aziz, Q., & Tack, J. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000220 · Cited by 16
Self-citation
High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility
Sood, V., Kaul, A., El‐Chammas, K. I., Mukkada, V. A., Sun, Q., Fei, L., & Santucci, N. R. (2024) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12245 · Cited by 18
Subjective health complaints and illness perception amongst adults with Joint Hypermobility Syndrome/Ehlers–Danlos Syndrome-HypermobilityType – a cross-sectional study
Hope, L., Juul‐Kristensen, B., Løvaas, H., Løvvik, C., & Mæland, S. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1390695 · Cited by 16
Arthralgias, fatigue, paresthesias and visceral pain: can joint hypermobility solve the puzzle? A case report
Folci, M., & CAPSONI, F. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-0905-2 · Cited by 17
Psychosocial and Motor Characteristics of Patients With Hypermobility
Lamari, M. M., Lamari, N. M., Filho, G. M. D. A., de Medeiros, M. P., Marques, V. R. P., & Pavarino, É. C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.787822 · Cited by 16
Multidisciplinary Chronic Pain Management Strategies in Patients with Ehlers–Danlos Syndromes
Gullapalli, P. A., & Javed, S. (2022) · Pain Management · doi:10.2217/pmt-2022-0050 · Cited by 14
Histological and mechanical differences in the skin of patients with rectal prolapse
Joshi, H., Woods, A., Smyth, E. A. E., Gosselink, M. P., Cunningham, C., Lindsey, I., Urban, J., Jones, O. M., & Vollrath, F. (2015) · International Journal of Colorectal Disease · doi:10.1007/s00384-015-2222-x · Cited by 14
Clinical Relevance of Joint Hypermobility and Its Impact on Musculoskeletal Pain and Bone Mass
Guarnieri, V., & Castori, M. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0460-x · Cited by 15
An overview of Ehlers Danlos syndrome and the link between postural orthostatic tachycardia syndrome and gastrointestinal symptoms with a focus on gastroparesis
Wu, W. K. K., & Ho, V. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1379646 · Cited by 16
Neuroimmunogastroenterology: At the Interface of Neuroimmunology and Gastroenterology
Sanchez, J. M. S., McNally, J. S., Cortez, M. M., Hemp, J., Pace, L., & Clardy, S. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00787 · Cited by 13
Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study
Fragkos, K. C., Keetarut, K., Cox, A., Eady, J., Emmanuel, A. V., & Zarate-Lopez, N. (2019) · Gastroenterology Research · doi:10.14740/gr1133 · Cited by 11
Celiac Disease in Uzbek Children: Insights into Disease Prevalence and Clinical Characteristics in Symptomatic Pediatric Patients
Kamilova, A. T., Azizova, G. K., Poddighe, D., Umarnazarova, Z. E., Abdullaeva, D. A., Geller, S. I., & Azimova, N. D. (2023) · Diagnostics · doi:10.3390/diagnostics13193066 · Cited by 14

Authors: zarate, N., farmer, A. D., grahame, R., mohammed, S. D., knowles, C. H., scott, S. M., & aziz, Q.
Affiliations: Queen Mary University of London (GB)
University College London (GB)
Corresponding author: aziz, q.
ORCID: farmer, a. d.
mohammed, s. d.
knowles, c. h.
scott, s. m.
aziz, q.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2010-03
Volume: 22
Issue: 3
Pages: 252-e78
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2009.01421.x
OpenAlex: W2033706886
Cited by: 178
References: 50
Citations by year: 2026: 2 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 9 · 2018: 10 · 2017: 18 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 8
FWCI: 8.14
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2010 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Funders: British Society for Rheumatology
Rosetrees Trust
Medical Research Council
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: joint hypermobility, benign joint hypermobility syndrome, functional gastrointestinal disorders, connective tissue diseases, gastrointestinal motility disorders, delayed gastric emptying, abdominal pain, bloating, gastroesophageal reflux, constipation, diarrhea
MeSH terms: Adolescent, Adult, Aged, Connective Tissue, Female, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Joint Instability, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks