Functional–anatomical implications of the nucleus accumbens core and shell subterritories

ZAHM, DANIEL S.

doi:10.1111/j.1749-6632.1999.tb09264.x

Cited by 384Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Functional–anatomical implications of the nucleus accumbens core and shell subterritories

ZAHM, DANIEL S.·1999·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.1999.tb09264.x

Open this paper in CoChat — free account

Abstract

The nucleus accumbens, a major part of the ventral striatum, comprises numerous subterritories and compartments, of which the core and shell appear to be dominant. Shell exhibits greater chemical neuroanatomical diversity than core and is rather directly connected to it by a robust, feed-forward, striatopallido-thalamocortico-striatal pathway. Shell and extended amygdala share afferents, but the two are distinguished by their outputs, strongly toward cortex for shell and descendent toward brain stem effector sites for extended amygdala. Shell responds independently to stimulation by excitatory amino acids and dopamine, which are more mutually permissive in the core. Accordingly, the shell responds to a broad variety of physiological and pharmacological stimuli, including psychomotor and opioid drugs. Whereas locomotion and oro-facial movements are elicitable from the shell, lesions and blockade of EAA transmission in the core reduce locomotion. It is hypothesized that core-shell has a feed-forward functional organization.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.1999.tb09264.x

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Some signals from the ventromedial striatum go back to the ventromedial striatum via the infralimbic cortex, and some reach the accumbens core via the prelimbic cortex and dorsal agranular insular cortex.
“While some signals from the ventromedial striatum go back to the ventromedial striatum via the infralimbic cortex, some signals reach the accumbens core via the prelimbic cortex, as suggested by Zahm (1999), and via the dorsal agranular insular cortex, apparently participating in lateral information flow.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Zahm, 1999

Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Self-citation
New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217 · see citing works
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works
Self-citation
On the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040 · see citing works
Self-citation
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
Pontieri, F. E., Tanda, G., & Chiara, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12304 · Cited by 868 · see citing works
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760 · see citing works
Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography
Groenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90339-9 · Cited by 732 · see citing works
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat
Saper, C. B., Swanson, L. W., & Cowan, W. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901830402 · Cited by 509 · see citing works
Chapter 5 The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization
Groenewegen, H. J., Berendse, H. W., Wolters, J. G., & Lohman, A. H. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62677-1 · Cited by 506 · see citing works
Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study
Záborszky, L., Alheid, G. F., Beinfeld, M. C., Eiden, L. E., Heimer, L., & Palkovits, M. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90302-1 · Cited by 489 · see citing works
Neuroleptics increase C-FOS expression in the forebrain: Contrasting effects of haloperidol and clozapine
Robertson, G. S., & Fibiger, H. C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90054-6 · Cited by 474 · see citing works
Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell
Deutch, A. Y., & Cameron, D. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90007-o · Cited by 461 · see citing works
Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456 · see citing works
Efferent connections of the ventral pallidum: Evidence of a dual striato pallidofugal pathway
Haber, S. N., Groenewegen, H. J., Grove, E. A., & Nauta, W. J. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350304 · Cited by 432 · see citing works
The accumbens: beyond the core-shell dichotomy
Heimer, L., Alheid, G. F., de Olmos, J. S., Groenewegen, H. J., Haber, S. N., Harlan, R. E., & Zahm, D. S. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.354 · Cited by 418 · see citing works
Self-citation
Two transpallidal pathways originating in the rat nucleus accumbens
Zahm, D. S., & Heimer, L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020302 · Cited by 406 · see citing works
Self-citation
Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
Kalivas, P. W., & Duffy, P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00013-g · Cited by 395 · see citing works
Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus
Maldonado-Irizarry, C. S., Swanson, C., & Kelley, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06779.1995 · Cited by 390 · see citing works
Specificity in the efferent projections of the nucleus accumbens in the rat: Comparison of the rostral pole projection patterns with those of the core and shell
Zahm, D. S., & Heimer, L. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270205 · Cited by 385 · see citing works
Self-citation
Compartmental organization of the ventral striatum of the rat: Immunohistochemical distribution of enkephalin, substance P, dopamine, and calcium‐binding protein
Voorn, P., Gerfen, C. R., & Groenewegen, H. J. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902890202 · Cited by 359 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain–prefrontal cortex topography
Ray, J. P., & Price, J. L. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903230204 · Cited by 326 · see citing works
Piecing together the Puzzle of Basal Forebrain Anatomy
Heimer, L., & Alheid, G. F. (1991) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-0145-6_1 · Cited by 310 · see citing works
Substantia innominata: a notion which impedes clinical–anatomical correlations in neuropsychiatric disorders
Heimer, L., Harlan, R. E., Alheid, G. F., Garcia, M. M., & de Olmos, J. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00405-8 · Cited by 286 · see citing works
Efferent connections of the lateral hypothalamic area of the rat: An autoradiographic investigation
Berk, M. L., & Finkelstein, J. A. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90009-0 · Cited by 260 · see citing works
Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine.
Pierce, R. C., & Kalivas, P. W. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12090-9 · Cited by 249 · see citing works
Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action
Deutch, A. Y., Lee, M. C., & Iadarola, M. J. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90030-6 · Cited by 240 · see citing works
Cell clusters in the nucleus accumbens of the rat, and the mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminations
Herkenham, M. A., Edley, S. M., & Stuart, J. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90045-9 · Cited by 236 · see citing works
Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat
Meredith, G. E., Agolia, R., Arts, M. P. M., Groenewegen, H. J., & Zahm, D. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90389-j · Cited by 231 · see citing works
Self-citation
Immunohistochemical Characterization of the Shell and Core Territories of the Nucleus Accumbens in the Rat
Jongen‐Rêlo, A. L., Voorn, P., & Groenewegen, H. J. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00315.x · Cited by 227 · see citing works
Expression of the d3 dopamine receptor in peptidergic neurons of the nucleus accumbens: Comparison with the D1 and D2 dopamine receptors
Moine, C. L., & Bloch, B. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00029-2 · Cited by 225 · see citing works
Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats
G�rard, C., Mestikawy, S. E., Lebrand, C., Adrien, J., Ruat, M., Traiffort, É., Hamon, M., & Martres, M. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199607)23:3 · Cited by 194 · see citing works
Patterns of convergence and segregation in the medial nucleus accumbens of the rat: Relationships of prefrontal cortical, midline thalamic, and basal amygdaloid afferents
Wright, C. I., & Groenewegen, H. J. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610304 · Cited by 194 · see citing works
Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty
Rebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 184 · see citing works
The organization of the descending ventral pallidal projections in the monkey
Haber, S., Lynd-Balta, E., & Mitchell, S. (1993) · The Journal of comparative neurology · doi:10.1002/cne.903290108 · Cited by 184 · see citing works
Interconnected Parallel Circuits between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of Pseudorabies Virus
O’Donnell, P., Lavı́n, A., Enquist, L. W., Grace, A. A., & Card, J. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-06-02143.1997 · Cited by 175 · see citing works
Habit-forming actions of nomifensine in nucleus accumbens
Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170 · see citing works
Effects of dopamine depletion in the medial prefrontal cortex on the stress-induced increase in extracellular dopamine in the nucleus accumbens core and shell
King, D. E., Zigmond, M. J., & Finlay, J. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00421-6 · Cited by 168 · see citing works
Patterns of overlap and segregation between insular cortical, intermediodorsal thalamic and basal amygdaloid afferents in the nucleus accumbens of the rat
Wright, C. I., & Groenewegen, H. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00592-7 · Cited by 148 · see citing works
Compartments in rat dorsal and ventral striatum revealed following injection of 6-hydroxydopamine into the ventral mesencephalon
Zahm, D. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90675-l · Cited by 127 · see citing works
Self-citation
An electron microscopic morphometric comparison of tyrosine hydroxylase immunoreactive innervation in the neostriatum and the nucleus accumbens core and shell
Zahm, D. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90102-f · Cited by 126 · see citing works
Self-citation
On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric dialysis probes
Chiara, G. D., Tanda, G., Frau, R., & Carboni, E. (1993) · Psychopharmacology · doi:10.1007/bf02244939 · Cited by 125 · see citing works
Sensorimotor gating in rats is regulated by different dopamine-glutamate interactions in the nucleus accumbens core and shell subregions
Wan, F.-J., & Swerdlow, N. R. (1996) · Brain Research · doi:10.1016/0006-8993(96)00209-0 · Cited by 124 · see citing works
Direct comparison of projections from the central amygdaloid region and nucleus accumbens shell
Zahm, D. S., Jensen, S. L., Williams, E. S., & Martin, J. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00524.x · Cited by 121 · see citing works
Self-citation
Differential behavioral effects following microinjection of an NMDA antagonist into nucleus accumbens subregions
Maldonado-Irizarry, C. S., & Kelley, A. E. (1994) · Psychopharmacology · doi:10.1007/bf02244872 · Cited by 120 · see citing works
Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward
Carlezon, W. A., Wise, R. A., & Carlezon, W. A. (1996) · Psychopharmacology · doi:10.1007/s002130050151 · Cited by 119 · see citing works
Chapter 28 Theories of basal forebrain organization and the “emotional motor system”
Alheid, G. F., & Heimer, L. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61882-8 · Cited by 115 · see citing works
Effects of dopamine depletion on the morphology of medium spiny neurons in the shell and core of the rat nucleus accumbens
Meredith, G., Ypma, P., & Zahm, D. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03808.1995 · Cited by 112 · see citing works
Self-citation
Presynaptic dopamine-glutamate interactions in the nucleus accumbens regulate sensorimotor gating
Wan, F. J., Geyer, M. A., & Swerdlow, N. R. (1995) · Psychopharmacology · doi:10.1007/bf02245815 · Cited by 112 · see citing works
Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system
Glazner, G. W., Mu, X., & Springer, J. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980202)391:1 · Cited by 110 · see citing works
Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat
Pulvirenti, L., Berrier, R., Kreifeldt, M., & Koob, G. K. (1994) · Brain Research · doi:10.1016/0006-8993(94)91977-1 · Cited by 109 · see citing works
Indirect nucleus accumbens input to the prefrontal cortex via the substantia nigra pars reticulata: A combined anatomical and electrophysiological study in the rat
Deniau, J., Menetrey, A., & Thierry, A. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90432-4 · Cited by 108 · see citing works
Withdrawal of repeated cocaine decreases autoradlographic [3H]mazindol-labelling of dopamine transporter In rat nucleus aecumbens
Sharpe, L. G., Pilotte, N. S., Mitchell, W. M., & Souza, E. B. D. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90804-y · Cited by 107 · see citing works
Localization of serotonin-4 receptors in the striatonigral pathway in rat brain
Patel, S., Roberts, J. C., Moorman, J. M., et al. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00314-9 · Cited by 92 · see citing works
Position of the ventral pallidum in the rat prefrontal cortex–basal ganglia circuit
Maurice, N., Deniau, J., Menetrey, A., Glowinski, J., & Thierry, A. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00002-x · Cited by 89 · see citing works
Excitotoxic lesions of the core and shell subregions of the nucleus accumbens differentially disrupt body weight regulation and motor activity in rat
Maldonado-Irizarry, C. S., & Kelleyt, A. E. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02030-2 · Cited by 85 · see citing works
Involvement of adenosine and glutamate receptors in the induction ofc-fos in the striatum by haloperidol
Boegman, R. J., & Vincent, S. R. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199601)22:1 · Cited by 84 · see citing works
Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats
Prinssen, E. P. M., Balestra, W., Bemelmans, F. F. J., & Cools, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01555.1994 · Cited by 84 · see citing works
Functional interaction of dopamine and glutamate in the nucleus accumbens in the regulation of locomotion
Wu, M., Brudzyński, S. M., & Mogenson, G. J. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-061 · Cited by 83 · see citing works
Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens
Marcus, M. M., Nomikos, G. G., & Svensson, T. H. (1996) · European Neuropsychopharmacology · doi:10.1016/0924-977x(95)00056-u · Cited by 69 · see citing works
Is the Caudomedial Shell of the Nucleus Accumbens Part of the Extended Amygdala? A Consideration of Connections
Zahm, D. S. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i3.50 · Cited by 66 · see citing works
Self-citation
Involvement of the ventral tegmental area in locomotion elicited from the nucleus accumbens or ventral pallidum.
Johnson, K., Churchill, L., Klitenick, M. A., Hooks, M. S., & Kalivas, P. W. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12900-5 · Cited by 63 · see citing works
The role of endogenous dopamine in the hypermotility response to intra-accumbens AMPA
Boldry, R. C., Willins, D. L., Wallace, L. J., & Uretsky, N. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90292-4 · Cited by 56 · see citing works
Psychostimulant drugs increase glucose utilization in the shell of the rat nucleus accumbens
Pontieri, F. E., Colangelo, V., Riccia, M. L., Pozzilli, C., Passarelli, F., & Orzi, F. (1994) · Neuroreport · doi:10.1097/00001756-199412000-00039 · Cited by 50 · see citing works
Anatomical comparison of the macaque and marsupial visual cortex: Common features that may reflect retention of essential cortical elements
Tyler, C., Dunlop, S. A., Lund, R. D., Harman, A. M., Dann, J. F., Beazley, L. D., & Lund, J. S. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981102)400:4 · Cited by 49 · see citing works
Subsets of neurotensin-immunoreactive neurons revealed following antagonism of the dopamine-mediated suppression of neurotensin immunoreactivity in the rat striatum
Zahm, D. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90056-8 · Cited by 47 · see citing works
Self-citation
The Circuitry Mediating the Translation of Motivational Stimuli Into Adaptive Motor Responses
Kalivas, P. W., Churchill, L., & Klitenick, M. A. (2019) · CRC Press eBooks · doi:10.1201/9780429274411-8 · Cited by 47 · see citing works
Contralateral turning elicited by unilateral stimulation of dopamine D2 and D1 receptors in the nucleus accumbens of rats is due to stimulation of these receptors in the shell, but not the core, of this nucleus
Koshikawa, N., Kitamura, M., Kobayashi, M., & Cools, A. R. (1996) · Psychopharmacology · doi:10.1007/bf02246447 · Cited by 44 · see citing works
Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine.
Boulay, D., Duterte‐Boucher, D., Leroux‐Nicollet, I., Naudon, L., & Costentin, J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20139-2 · Cited by 38 · see citing works
Transition Areas of the Striatopallidal System with the Extended Amygdala in the Rat and Primate: Observations from Histochemistry and Experiments with Mono- and Transsynaptic Tracer
Alheid, G. F., Beltramino, C. A., Braun, A., Miselis, R. R., François, C., & de Olmos, J. S. (1994) · Advances in behavioral biology · doi:10.1007/978-1-4613-0485-2_9 · Cited by 32 · see citing works
Basal Forebrain Organization: An Anatomical Framework for Motor Aspects of Drive and Motivation
Heimer, L., Alheid, G. F., & Zahm, D. S. (2019) · CRC Press eBooks · doi:10.1201/9780429274411-1 · Cited by 30 · see citing works
Self-citation
Morphometric analysis of ventral mesencephalic neurons retrogradely labeled with Fluoro-Gold following injections in the shell, core and rostral pole of the rat nucleus accumbens
Tan, Y., Brog, J. S., Williams, E. S., & Zahm, D. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00556-6 · Cited by 29 · see citing works
Self-citation
Intravenous morphine increases glucose utilization in the shell of the rat nucleus accumbens
Orzi, F., Passarelli, F., Riccia, M. L., Grezia, R. D., & Pontieri, F. E. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00128-8 · Cited by 27 · see citing works
Sites and Mechanisms of Action of Antipsychotic Drugs as Revealed by Immediate-Early Gene Expression
Deutch, A. Y. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-61007-3_5 · Cited by 25 · see citing works
Calbindin-D 28kD immunofluorescence in ventral mesencephalic neurons labeled following injections of Fluoro-Gold in nucleus accumbens subterritories: inverse relationship relative to known neurotoxin vulnerabilities
Tan, Y., Williams, E. S., & Zahm, D. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01890-9 · Cited by 25 · see citing works
Self-citation
The rat nucleus accumbens: two levels of complexity in the distribution of glutamic acid decarboxylase (67 kDa) and preproenkephalin messenger RNA
Rogard, M., Caboche, J., Julie, J.-F., & Besson, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90678-e · Cited by 22 · see citing works
Patterns of glucose use after bicuculline-induced convulsions in relationship to γ-aminobutyric acid and μ-opioid receptors in the ventral pallidum — functional markers for the ventral pallidum
Churchill, L., Cross, R. S., Pazdernik, T. L., Nelson, S. R., Zahm, D. S., Heimer, L., & Kalivas, P. W. (1992) · Brain Research · doi:10.1016/0006-8993(92)90341-6 · Cited by 19 · see citing works
Self-citation
Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; jaw movements
Koshikawa, N., Miwa, Y., Adachi, K., et al. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00301-9 · Cited by 19 · see citing works
An acetylcholinesterase-mediated density shift technique demonstrates that coated vesicles from chick myotubes may contain both newly synthesized acetylcholinesterase and acetylcholine receptors
Porter-Jordan, K., Benson, R. J., Buoniconti, P., et al. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-11-03112.1986 · Cited by 18 · see citing works
The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques
Gispen, W. H., Oestreicher, A. B., & Rozemüller, A. J. M. (1993) · Utrecht University Repository (Utrecht University) · Cited by 17 · see citing works
Haloperidol increases PPE mRNA levels in the caudal part of the nucleus accumbens in the rat
Caboche, J., Vernier, P., Rogard, M., et al. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00022 · Cited by 15 · see citing works
Behavioural effects of 7-OH-DPAT are solely due to stimulation of dopamine D2 receptors in the shell of the nucleus accumbens; turning behaviour
Koshikawa, N., Kitamura, M., Kobayashi, M., et al. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00302-0 · Cited by 11 · see citing works
Untitled work
Xiao (1998) · doi:10.1002/(sici)1098-2396(199808)29:4
Untitled work
Zahm (1996) · doi:10.1002/(sici)1096-9861(19960108)364:2

Flagged first, then by citations

Sorted by citations

Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis
O'Connell, L. A., & Hofmann, H. A. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22735 · Cited by 986 · see citing works
The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics
Heidbreder, C. A., & Groenewegen, H. J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.09.003 · Cited by 882 · see citing works
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629 · see citing works
The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
Joel, D., & Weiner, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00575-8 · Cited by 614 · see citing works
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561 · see citing works
The role of the nucleus accumbens in instrumental conditioning: evidence of a functional dissociation between accumbens core and shell
Corbit, L. H., Muir, J. L., & Balleine, B. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03251.2001 · Cited by 564 · see citing works
The nucleus accumbens: a comprehensive review
Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery · doi:10.1159/000368279 · Cited by 489 · see citing works
Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354 · see citing works
The persistence of maladaptive memory: Addiction, drug memories and anti-relapse treatments
Milton, A. L., & Everitt, B. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.002 · Cited by 279 · see citing works
Striatal Contributions to Reward and Decision Making: Making Sense of Regional Variations in a Reiterated Processing Matrix
WICKENS, J. R., BUDD, C. S., HYLAND, B. I., & ARBUTHNOTT, G. W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.016 · Cited by 165 · see citing works
Dissociable control of impulsivity in rats by dopamine D2/3 receptors in the core and shell subregions of the nucleus accumbens
Besson, M., Belin, D., McNamara, R., Theobald, D. E., Castel, A., Beckett, V. L., Crittenden, B. M., Newman, A. H., Everitt, B. J., Robbins, T. W., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.162 · Cited by 143 · see citing works
The nucleus accumbens and reward: neurophysiological investigations in behaving animals
Carelli, R. M. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302238338 · Cited by 131 · see citing works
Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat
Schmidt, H. D., Anderson, S. M., & Pierce, R. C. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04524.x · Cited by 119 · see citing works
Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: a microdialysis study
Rahman, S., Zhang, J., Engleman, E. A., & Corrigall, W. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.010 · Cited by 110 · see citing works
Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards
Cameron, C. M., Wightman, R. M., & Carelli, R. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.006 · Cited by 109 · see citing works
Hunger and Satiety Gauge Reward Sensitivity
Cassidy, R. M., & Tong, Q. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00104 · Cited by 93 · see citing works
Cellular activation in limbic brain systems during social play behaviour in rats
van Kerkhof, L. W. M., Trezza, V., Mulder, T., Gao, P., Voorn, P., & Vanderschuren, L. J. M. J. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0558-y · Cited by 83 · see citing works
High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats
Mundt, A., Klein, J., Joel, D., Heinz, A., Djodari‐Irani, A., Harnack, D., Kupsch, A., Orawa, H., Juckel, G., Morgenstern, R., et al. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06777.x · Cited by 80 · see citing works
Dopamine and monogamy
Curtis, J. T., Liu, Y., Aragona, B. J., & Wang, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.126 · Cited by 74 · see citing works
Effects of AMPA/kainate receptor blockade on responses to dopamine receptor agonists in the core and shell of the rat nucleus accumbens
Choi, K. H., Zarandi, B., Todd, K. G., Biondo, A. M., & Greenshaw, A. J. (2000) · Psychopharmacology · doi:10.1007/s002130000391 · Cited by 23 · see citing works

Quantitative Mapping of Cocaine-Induced ΔFosB Expression in the Striatum of Male and Female Rats
Sato, S. M., Wissman, A. M., McCollum, A. F., & Woolley, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021783 · Cited by 18 · see citing works
Long-term Effects of Maternal Deprivation on the Volume, Number and Size of Neurons in the Amygdala and Nucleus Accumbens of Rats.
Aleksić, D., Aksić, M., Radonjić, N. V., Jovanović, A., Marković, B., Petronijević, N., Radonjić, V., Mališ, M., & Filipović, B. (2016) · PubMed · Cited by 20 · see citing works
Adjusting Behavior to Context: Striatal Network Functions in Learning and Memory
Graybiel, A. M., & Blázquez, P. M. (2002) · Advances in behavioral biology · doi:10.1007/978-1-4757-3538-3_86 · Cited by 1 · see citing works
Effect of ethanol on ascorbate release in the nucleus accumbens and striatum of freely moving rats
Svensson, L., Wu, C., Johannessen, K., & Engel, J. A. (1992) · Alcohol · doi:10.1016/0741-8329(92)90093-p · Cited by 14 · see citing works
Age-Related Changes in the Capacity, Rate, and Modulation of Dopamine Uptake within the Striatum and Nucleus Accumbens of Fischer 344 Rats: An In Vivo Electrochemical Study
Hebert, M. A., & Gerhardt, G. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38033-4 · Cited by 58 · see citing works

Authors: ZAHM, D. S.
Affiliations: Saint Louis University (US)
Corresponding author: ZAHM, DANIEL S.
ORCID: ZAHM, DANIEL S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 1999-06
Volume: 877
Issue: 1
Pages: 113-128
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.1999.tb09264.x
OpenAlex: W2154129069
Cited by: 384
References: 87
Citations by year: 2026: 4 · 2025: 14 · 2024: 11 · 2023: 18 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 20 · 2018: 11 · 2017: 10 · 2016: 8 · 2015: 18 · 2014: 18 · 2013: 20 · 2012: 16
FWCI: 1.04
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2442 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS23805, R01NS023805)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, ventral striatum, extended amygdala, dopamine, excitatory amino acids, locomotion, opioids
MeSH terms: Amygdala, Animals, Brain Stem, Humans, Models, Neurological, Neural Pathways, Nucleus Accumbens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional–anatomical implications of the nucleus accumbens core and shell subterritories

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks