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Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety
Abstract
Several studies suggest a role for arginine vasopressin (AVP), particularly in the lateral septum, in the regulation of intermale aggression. We used intracerebral microdialysis to monitor the local in vivo AVP release within the mediolateral septum of adult male Wistar rats bred for low (LAB) or high (HAB) anxiety-related behaviour during exposure to the resident-intruder test. LAB residents showed a significantly higher level of aggression than HAB residents, as reflected by more time spent with lateral threat, offensive upright and total aggressive behaviour as well as by more attacks and a shorter attack latency. Septal AVP release was significantly decreased in high-aggressive LAB males, while septal AVP release tended to increase in HAB males during resident-intruder test exposure. Moreover, LAB residents showed reduced neuronal activation of the lateral septum, as indicated by fewer c-Fos-positive cells, 1 h after the resident-intruder test. Pharmacological manipulation of the septal AVP system by local application of either synthetic AVP to LAB residents or the selective V1a receptor antagonist d(CH(2))(5)Tyr(Me)AVP to HAB residents did not change the level of aggression. However, application of AVP into the septum enhanced anxiety-related behaviour on the elevated plus-maze in LAB males, while local administration of the V1a receptor antagonist reduced social investigation in HAB males during the resident-intruder test. In conclusion, although AVP release patterns within the septum are dependent on the level of aggression, locally released AVP does not seem to be directly involved in the regulation of aggression, but rather modulates non-aggressive social and anxiety-related behaviours.
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“Because AVP typically enhances (Landgraf et al., 1995; Beiderbeck et al., 2007) while OXT reduces (Windle et al., 1997; Ring et al., 2006; Blume et al., 2008) anxiety-like behaviors of rats exposed to novel environments”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“The 3-day recovery period matches that used for other procedures applied routinely in our lab (e.g., intracerebral microdialysis) and was shown not to affect the display of social behavior (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“yet it had a strong anxiogenic effect on elevated plus-maze behavior, confirming previous findings in adult male rats (Landgraf et al., 1995; Beiderbeck et al., 2007; Veenema et al., 2010).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“The lateral septum (LS) is a key brain region involved in social behavior, motivation, and reward (Clarke and File, 1982;Goodson et al., 1997;Beiderbeck et al., 2007;Scotti et al., 2011;Luo et al., 2011;McDonald et al., 2012;Veenema et al., 2012;Lukas et al., 2013;Harasta et al., 2015).”
From Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum (2025) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“Importantly, we do not find effects of surgery and cannula or probe implantation after two days on behavior in various behavioral tests (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“extracellular AVP release in the LS decreased during intermale aggression in rats showing high levels of aggression (Beiderbeck, Neumann, & Veenema, 2007).”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Beiderbeck et al., 2007
In the citing paper
“Taken together, these studies suggest that the role of AVP in this circuit largely depends on individual differences in innate levels of intermale aggression, and that higher AVP-ir may not directly translate to higher levels of aggression.”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Beiderbeck et al., 2007
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Metadata
- Authors
- Beiderbeck, D. I., Neumann, I. D., & Veenema, A. H.
- Affiliations
- University of Regensburg (DE)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 26
- Issue
- 12
- Pages
- 3597-3605
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1653039463
- Cited by
- 142
- References
- 48
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 9
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, male-male aggression, lateral septum, anxiety-like behavior, resident-intruder test, V1a receptor, d(CH2)5Tyr(Me)AVP, c-Fos neuronal activation, social investigation, elevated plus maze, intracerebral microdialysis
- MeSH terms
- Aggression, Animals, Anxiety, Arginine Vasopressin, Behavior, Animal, Breeding, Exploratory Behavior, Fear, Female, Male, Septal Nuclei, Social Behavior, Territoriality, Proto-Oncogene Proteins c-fos, Rats, Wistar, Microdialysis, Maze Learning, Rats, Antidiuretic Hormone Receptor Antagonists
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