Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats

Engelmann, Mario; Landgraf, Rainer

doi:10.1016/0031-9384(94)90022-1

Cited by 225Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats

Engelmann, Mario, Landgraf, Rainer·1994·Physiology & Behavior

DOI 10.1016/0031-9384(94)90022-1

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Abstract

The role of septal arginine vasopressin (AVP) in a social recognition test was investigated in both homozygous Brattleboro (HO-DI) and normal Long-Evans rats. To do this, the duration of investigation of conspecific juveniles by untreated adult males of both rat strains was measured before and after inter exposure intervals of 30 and 120 min. Additionally, a microdialysis administration technique was used to administer synthetic AVP (0.2 or 2.0 ng) or its V1 receptor antagonist d(CH2)5Tyr(Me)AVP (5.0 ng) into the mediolateral septum concomitantly with the behavioral test. Untreated HO-DI rats showed an impaired social recognition compared with untreated Long-Evans rats. A similarly impaired performance was observed after V1 receptor antagonist treatment of Long-Evans rats. Microdialysis administration of synthetic AVP, on the other hand, significantly improved social recognition in both rat strains. The data suggest that endogenous AVP in the septal brain area is critically involved in the acquisition, storage, and/or recall of olfactory cues in rats.

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Blockade of the AVP V1A receptor in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it.
“Here, blockade of the AVP V1A receptor (V1AR) in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it (Dantzer et al., 1988; Engelmann & Landgraf, 1994; Everts & Koolhaas, 1997; Lukas, Toth, Veenema, & Neumann, 2013; Veenema et al., 2012).”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Engelmann & Landgraf, 1994
Administration of AVP into the septum improves social recognition in male Brattleboro rats, a mutant rat strain that naturally lacks AVP.
“administration of AVP into the septum improves social recognition in male Brattleboro rats, a mutant rat strain that naturally lacks AVP [64].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [64]

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“Here, blockade of the AVP V1A receptor (V1AR) in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it (Dantzer et al., 1988; Engelmann & Landgraf, 1994; Everts & Koolhaas, 1997; Lukas, Toth, Veenema, & Neumann, 2013; Veenema et al., 2012).”
Background
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Authors: Engelmann, M., & Landgraf, R.
Affiliations: Leipzig University (DE)
Max Planck Society (DE)
Corresponding author: Landgraf, Rainer
ORCID: Engelmann, Mario
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 1994-01
Volume: 55
Issue: 1
Pages: 145-149
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/0031-9384(94)90022-1
OpenAlex: W2079258652
Cited by: 225
References: 41
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 8
FWCI: 7.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: vasopressin, septum, social recognition, Brattleboro rats, V1 vasopressin receptor, d(CH2)5Tyr(Me)AVP, microdialysis, olfactory cues, social behavior, hypothalamic-pituitary dysfunction
MeSH terms: Animals, Arginine Vasopressin, Brain Mapping, Male, Rats, Brattleboro, Mental Recall, Septum Pellucidum, Social Behavior, Social Environment, Species Specificity, Microdialysis, Rats

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Microdialysis administration of vasopressin into the septum improves social recognition in Brattleboro rats

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