Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas

Shen, Xiang Jun; Rawls, John F.; Randall, Thomas A.; Burcall, Lauren; Mpande, Caroline; Jenkins, Natascha; Jovov, Biljana; Abdo, Zaid; Sandler, Robert S.; Keku, Temitope O.

doi:10.4161/gmic.1.3.12360

Cited by 418Gut microbiota and healthColorectal Cancer Screening and DetectionOral microbiology and periodontitis research

Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas

Open access

Shen, Xiang Jun, Rawls, John F., Randall, Thomas A., Burcall, Lauren, Mpande, Caroline, Jenkins, Natascha, Jovov, Biljana, Abdo, Zaid +2 more·2010·Gut Microbes

DOI 10.4161/gmic.1.3.12360PMC PMC2927011

Open this paper in CoChat — free account Open PDF

Abstract

The human large bowel is colonized by complex and diverse bacterial communities. However, the relationship between commensal bowel bacteria and adenomas (colorectal cancer precursors) is unclear. This study aimed to characterize adherent bacteria in normal colon and evaluate differences in community composition associated with colorectal adenomas. We evaluated adherent bacteria in normal colonic mucosa of 21 adenoma and 23 non-adenoma subjects enrolled in a cross sectional study. Terminal restriction fragment length polymorphism, clone sequencing and fluorescent in-situ hybridization analysis of the 16S rRNA genes were used to characterize adherent bacteria. A total of 335 clones were sequenced and processed for phylogenetic and taxonomic analysis. Differences in bacterial composition between cases and controls were evaluated by UniFrac and analysis of similarity matrix. Overall, Firmicutes (62%), Bacteroidetes (26%) and Proteobacteria (11%) were the most dominant phyla. The bacterial composition differed significantly between cases and controls (UniFrac p < 0.001). We observed significantly higher abundance of Proteobacteria (p < 0.05) and lower abundance of Bacteroidetes (p < 0.05) in cases compared to controls. At the genus level, case subjects showed increased abundance of Dorea spp. (p < 0.005), Faecalibacterium spp. (p < 0.05) and lower proportions of Bacteroides spp. (p < 0.03) and Coprococcus spp. (p < 0.05) than controls. Cases had higher bacterial diversity and richness than controls. These findings reveal that alterations in bacterial community composition associated with adenomas may contribute to the etiology of colorectal cancer. Extension of these findings could lead to strategies to manipulate the microbiota to prevent colorectal adenomas and cancer as well as to identify individuals at high risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.4161/gmic.1.3.12360

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Colonic polyps demonstrate higher bacterial diversity and richness when compared with control patients, with higher abundance of mucosal Proteobacteria and lower abundance of Bacteroidetes.
“colonic polyps demonstrate higher bacterial diversity and richness when compared with control patients, with higher abundance of mucosal Proteobacteria and lower abundance of Bacteroidetes.92”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [92]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Change in marine communities : an approach to statistical analysis and interpretation
Clarke, K. R., & Warwick, R. M. (2001) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 12,075 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Quantitative and Qualitative β Diversity Measures Lead to Different Insights into Factors That Structure Microbial Communities
Lozupone, C., Hamady, M., Kelley, S. T., & Knight, R. D. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01996-06 · Cited by 2,717 · see citing works
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436 · see citing works
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Global patterns in bacterial diversity
Lozupone, C., & Knight, R. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611525104 · Cited by 1,832 · see citing works
Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490 · see citing works
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works
UniFrac – An online tool for comparing microbial community diversity in a phylogenetic context
Lozupone, C., Hamady, M., & Knight, R. D. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-371 · Cited by 1,454 · see citing works
Developmental microbial ecology of the neonatal gastrointestinal tract
Mackie, R. I., Sghir, A., & Gaskins, H. R. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1035s · Cited by 1,360 · see citing works
NAST: a multiple sequence alignment server for comparative analysis of 16S rRNA genes
DeSantis, T. Z., Hugenholtz, P., Keller, K., Brodie, E., Larsen, N., Piceno, Y. M., Phan, R., & Andersen, G. L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl244 · Cited by 1,028 · see citing works
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993 · see citing works
Mucosa-Associated Bacteria in the Human Gastrointestinal Tract Are Uniformly Distributed along the Colon and Differ from the Community Recovered from Feces
Zoetendal, E. G., von Wright, A., Vilpponen-Salmela, T., Ben-Amor, K., Akkermans, A. D. L., & de Vos, W. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.7.3401-3407.2002 · Cited by 868 · see citing works
Altered intestinal function in patients with chronic heart failure
Sandek, A., Bauditz, J., Swidsinski, A., Buhner, S., Weber-Eibel, J., von Haehling, S., Schroedl, W., Karhausen, T., Doehner, W., Rauchhaus, M., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.016 · Cited by 661 · see citing works
Phylogenetic Approaches for Describing and Comparing the Diversity of Microbial Communities
Martin, A. P. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.8.3673-3682.2002 · Cited by 519 · see citing works
Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA
Huycke, M. M., Abrams, V., & Moore, D. R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.529 · Cited by 489 · see citing works
Phylogenetic Analysis of the Human Gut Microbiota Using 16S rDNA Clone Libraries and Strictly Anaerobic Culture‐Based Methods
Hayashi, H., Sakamoto, M., & Benno, Y. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02731.x · Cited by 458 · see citing works
Statistical methods for characterizing diversity of microbial communities by analysis of terminal restriction fragment length polymorphisms of 16S rRNA genes
Abdo, Z., Schütte, U. M. E., Bent, S. J., Williams, C. J., Forney, L. J., & Joyce, P. (2005) · Environmental Microbiology · doi:10.1111/j.1462-2920.2005.00959.x · Cited by 407 · see citing works
Self-citation
Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?
Sonnenburg, J. L., Angenent, L. T., & Gordon, J. I. (2004) · Nature Immunology · doi:10.1038/ni1079 · Cited by 406 · see citing works
Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity
Liévin, V, Peiffer, I., Hudault, S., Rochat, F., Brassart, D., Neeser, J.-R., & Servin, A. L. (2000) · Gut · doi:10.1136/gut.47.5.646 · Cited by 397 · see citing works
Comparative study of the intestinal mucus barrier in normal and inflamed colon
Swidsinski, A. V., Loening-Baucke, V. A., Theissig, F., Engelhardt, H., Bengmark, S., Koch, S., Lochs, H. H., & Dörffel, Y. (2006) · Gut · doi:10.1136/gut.2006.098160 · Cited by 365 · see citing works
Enterococcus faecalis Induces Inflammatory Bowel Disease in Interleukin-10 Knockout Mice
Balish, E., & WARNER, T. F. C. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61172-8 · Cited by 352 · see citing works
Terminal Restriction Fragment Length Polymorphism Data Analysis for Quantitative Comparison of Microbial Communities
Blackwood, C. B., Marsh, T. L., Kim, S.-H., & Paul, E. A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.2.926-932.2003 · Cited by 341 · see citing works
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
Packey, C. D., & Sartor, R. B. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832a8a5d · Cited by 319 · see citing works
Hydrogen Sulfide Induces Direct Radical-Associated DNA Damage
Attene‐Ramos, M. S., Wagner, E. D., Gaskins, H. R., & Plewa, M. J. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0439 · Cited by 276 · see citing works
Biodiversity of the Mucosa-Associated Microbiota Is Stable Along the Distal Digestive Tract in Healthy Individuals and Patients With Ibd
Lepage, P., Seksik, P., Sutren, M., de la Cochetière, M.-F., Jian, R., Marteau, P., & Doré, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000159662.62651.06 · Cited by 270 · see citing works
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01503.x · Cited by 245 · see citing works
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
Huycke, M. M., & Gaskins, H. R. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900702 · Cited by 244 · see citing works
Early Intestinal Bacterial Colonization and Necrotizing Enterocolitis in Premature Infants: The Putative Role of Clostridium
de la Cochetière, M.-F., Piloquet, H., Robert, C. D., Darmaun, D., Galmiche, J., & Rozé, J. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000134251.45878.d5 · Cited by 224 · see citing works
Analysis of bacterial bowel communities of IBD patients: What has it revealed?
Sokol, H., Lay, C., Seksik, P., & Tannock, G. W. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20392 · Cited by 220 · see citing works
Bacteria as the cause of ulcerative colitis
Campieri, M., & Gionchetti, P. (2001) · Gut · doi:10.1136/gut.48.1.132 · Cited by 215 · see citing works
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.
Engle, S. J., Ormsby, I., Pawlowski, S. A., Boivin, G. P., Croft, J., Balish, E., & Doetschman, T. C. (2002) · PubMed · Cited by 199 · see citing works
Role of intestinal epithelial cells in the innate immune defence of the pig intestine
Oswald, I. P. (2006) · Veterinary Research · doi:10.1051/vetres:2006006 · Cited by 165 · see citing works
Bacterial Population Analysis of Human Colon and Terminal Ileum Biopsies with 16S rRNA-based Fluorescent Probes: Commensal Bacteria Live in Suspension and Have No Direct Contact with Epithelial Cells
van der Waaij, L. A., Harmsen, H. J. M., Madjipour, M., Kroese, F. G. M., Zwiers, M., van Dullemen, H. M., de Boer, N. K., Welling, G. W., & Jansen, P. L. M. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000179212.80778.d3 · Cited by 141 · see citing works
Effect of Colonic Bacterial Metabolites on Caco-2 Cell Paracellular Permeability In Vitro
Hughes, R., Kurth, M. J., McGilligan, V., McGlynn, H., & Rowland, I. R. (2008) · Nutrition and Cancer · doi:10.1080/01635580701649644 · Cited by 139 · see citing works
Microbiomic analysis of the bifidobacterial population in the human distal gut
Turroni, F., Marchesi, J. R., Foroni, E., Gueimonde, M., Shanahan, F., Margolles, A., van Sinderen, D., & Ventura, M. (2009) · The ISME Journal · doi:10.1038/ismej.2009.19 · Cited by 137 · see citing works
Colorectal carcinogenesis in germ-free and conventionally reared rats: Different intestinal environments affect the systemic immunity
Vannucci, L. E., Štëpánková, R., Kozáková, H., Fišerová, A., Rossmann, P., & Tlaskalová-Hogenová, H. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.3.609 · Cited by 128 · see citing works
Dysbiosis in Pouchitis: Evidence of Unique Microfloral Patterns in Pouch Inflammation
Komanduri, S., Gillevet, P. M., Sikaroodi, M., Mutlu, E., & Keshavarzian, A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.01.001 · Cited by 120 · see citing works
Microvessel quantification and its possible relation with liver metastasis in colorectal cancer
Tomisaki, S., Ohno, S., Ichiyoshi, Y., Kuwano, H., Maehara, Y., & Sugimachi, K. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960415)77:8 · Cited by 118 · see citing works
Comparison of Four Microbial Enzymes in Clostridia and Bacteroides Isolated from Human Feces
Nakamura, J., Kubota, Y., Miyaoka, M., Saitoh, T., Mizuno, F., & Benno, Y. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02723.x · Cited by 109 · see citing works
Role of bacteria in experimental colitis
Guarner, F., & Malagelada, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00068-4 · Cited by 96 · see citing works
Patterns and Scales in Gastrointestinal Microbial Ecology
Camp, J. G., Kanther, M., Semova, I., & Rawls, J. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.075 · Cited by 84 · see citing works
Self-citation
Molecular Analysis of Cytolysin A (ClyA) in Pathogenic Escherichia coli Strains
Ludwig, A., von Rhein, C., Bauer, S., Hüttinger, C., & Goebel, W. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.16.5311-5320.2004 · Cited by 82 · see citing works
[16] Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences
Schmidt, T. M., & Relman, D. A. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)35142-2 · Cited by 77 · see citing works
Characterization of Microbial Communities Found in the Human Vagina by Analysis of Terminal Restriction Fragment Length Polymorphisms of 16S rRNA Genes
Coolen, M. J. L., Post, E., Davis, C., & Forney, L. J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8729-8737.2005 · Cited by 63 · see citing works
Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study
Horie, H., Kanazawa, K., Okada, M., Narushima, S., Itoh, K., & Terada, A. (1999) · European Journal of Cancer Prevention · doi:10.1097/00008469-199906000-00012 · Cited by 51 · see citing works
Anaerobic bacterial populations on normal and diseased human biopsy tissue obtained at colonoscopy
Edmiston, C. E., Avant, G. R., & Wilson, F. A. (1982) · Applied and Environmental Microbiology · doi:10.1128/aem.43.5.1173-1181.1982 · Cited by 50 · see citing works
A Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune Responses
Hasegawa, M., Kawasaki, A., Yang, K., Fujimoto, Y., Masumoto, J., Breukink, E. J., Núñez, G., Fukase, K., & Inohara, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700846200 · Cited by 47 · see citing works
The Effects of Maturation on the Colonic Microflora in Infancy and Childhood
Enck, P., Zimmermann, K., Rusch, K., Schwiertz, A., Klosterhalfen, S., & Frick, J.-S. (2009) · Gastroenterology Research and Practice · doi:10.1155/2009/752401 · Cited by 41 · see citing works
Management of small intestinal bacterial overgrowth
Citters, G. W. V., & Lin, H. C. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0025-x · Cited by 34 · see citing works
Impact of commensal microbiota on murine gastrointestinal tract gene ontologies
Mutch, D. M., Simmering, R., Donnicola, D., Fotopoulos, G., Holzwarth, J. A., Williamson, G., & Corthesy-Theulaz, I. E. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00105.2004 · Cited by 30 · see citing works
Gut flora in gastrointestinal disease.
Shanahan, F. (2002) · PubMed · Cited by 17 · see citing works
Factors involved in the production of tissue damage by endotoxins derived from Gram-negative micro-organisms.
Ra, G., Fw, D., Rt, S., et al. (1953) · PubMed · Cited by 1 · see citing works
Untitled work
Kanazawa (1996) · doi:10.1002/(sici)1097-0142(19960415)77:8+

Flagged first, then by citations

Sorted by citations

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462 · see citing works
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302 · see citing works
“92 This may in part be explained by the mucosal defensive strategies designed to manage the commensal microbiota.”
Background
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
Dysbiosis of the gut microbiota in disease
Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.26191 · Cited by 1,710 · see citing works
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults
Weir, T. L., Manter, D. K., Sheflin, A. M., Barnett, B. A., Heuberger, A. L., & Ryan, E. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070803 · Cited by 642 · see citing works
The role of the microbiome in cancer development and therapy
Bhatt, A. P., Redinbo, M. R., & Bultman, S. J. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21398 · Cited by 653 · see citing works
Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity
Long, X., Wong, C. C., Tong, L., Chu, E. S. H., Ho Szeto, C., Go, M. Y. Y., Coker, O. O., Chan, A. W. H., Chan, F. K. L., Sung, J. J. Y., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0541-3 · Cited by 557 · see citing works
Towards the Human Colorectal Cancer Microbiome
Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020447 · Cited by 552 · see citing works
Microbiota disbiosis is associated with colorectal cancer
Gao, Z., Guo, B., Gao, R., Zhu, Q., & Qin, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00020 · Cited by 537 · see citing works
Colonization of the Human Gut by E. coli and Colorectal Cancer Risk
Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works
Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer
Arthur, J. C., Gharaibeh, R. Z., Mühlbauer, M., Perez-Chanona, E., Uronis, J. M., McCafferty, J., Fodor, A. A., & Jobin, C. (2014) · Nature Communications · doi:10.1038/ncomms5724 · Cited by 392 · see citing works
Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions
Baxter, N. T., Ruffin, M. T., Rogers, M. A. M., & Schloss, P. D. (2016) · Genome Medicine · doi:10.1186/s13073-016-0290-3 · Cited by 354 · see citing works
Structure of the gut microbiome following colonization with human feces determines colonic tumor burden
Baxter, N. T., Zackular, J. P., Chen, G. Y., & Schloss, P. D. (2014) · Microbiome · doi:10.1186/2049-2618-2-20 · Cited by 299 · see citing works
Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
Carroll, I. M., Ringel-Kulka, T., Keku, T. O., Chang, Y.-H., Packey, C. D., Sartor, R. B., & Ringel, Y. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2011 · Cited by 292 · see citing works
Self-citation
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
Tomkovich, S., Yang, Y., Winglee, K., Gauthier, J., Mühlbauer, M., Sun, X., Mohamadzadeh, M., Liu, X., Martin, P., Wang, G. P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3472 · Cited by 252 · see citing works
The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis
Rodriguez-Palacios, A., Harding, A., Menghini, P., Himmelman, C., Retuerto, M., Nickerson, K. P., Lam, M., Croniger, C. M., McLean, M. H., Durum, S. K., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy060 · Cited by 225 · see citing works
Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients
Li, Y.-Y., Ge, Q.-X., Cao, J., Zhou, Y.-J., Du, Y.-L., Shen, B., Wan, Y.-J. Y., & Nie, Y.-Q. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3227 · Cited by 175 · see citing works
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer
Arthur, J. C., Gharaibeh, R. Z., Uronis, J. M., Perez-Chanona, E., Sha, W., Tomkovich, S., Mühlbauer, M., Fodor, A. A., & Jobin, C. (2013) · Scientific Reports · doi:10.1038/srep02868 · Cited by 118 · see citing works
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works
A Novel Non-Digestible, Carrot-Derived Polysaccharide (cRG-I) Selectively Modulates the Human Gut Microbiota while Promoting Gut Barrier Integrity: An Integrated In Vitro Approach
Van den Abbeele, P., Verstrepen, L., Ghyselinck, J., Albers, R., Marzorati, M., & Mercenier, A. (2020) · Nutrients · doi:10.3390/nu12071917 · Cited by 73 · see citing works
Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00774 · Cited by 67 · see citing works
Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk
Kato, I., Boleij, A., Kortman, G. A. M., Roelofs, R., Djuric, Z., Severson, R. K., & Tjalsma, H. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.748922 · Cited by 46 · see citing works
A metagenomic study of the preventive effect ofLactobacillus rhamnosusGG on intestinal polyp formation in ApcMin/+mice
Ni, Y., Wong, V. H. Y., Tai, W. C. S., Li, J., Wong, W. Y., Lee, M. M. L., Fong, F. L. Y., El-Nezami, H., & Panagiotou, G. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13386 · Cited by 29 · see citing works
The role of host molecules in communication with the resident and pathogenic microbiota: A review
White, J. R., Dauros-Singorenko, P., Hong, J., Vanholsbeeck, F., Phillips, A., & Swift, S. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100005 · Cited by 21 · see citing works

Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population
Andoh, A., Nishida, A., Takahashi, K., Inatomi, O., Imaeda, H., Bamba, S., Kito, K., Sugimoto, M., & Kobayashi, T. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-152 · Cited by 256 · see citing works
Comparative analysis of the fecal microbiome and metabolomics of healthy versus captive South China tigers with mild diarrhea
Yuan, Y., Wu, H., & Pan, H. (2022) · Canadian Journal of Microbiology · doi:10.1139/cjm-2022-0115 · Cited by 5 · see citing works
Statistical Prediction Models for Identifying the Microbial Diversity and Interactions Due to Fixed Periodontal Appliances
Chandrababu, S., Bastola, D. K., & Premaraj, S. (2021) · International Conference on Bioinformatics Research and Applications (ICBRA) · doi:10.1145/3487027.3487031
Association study of gut flora in Wilson's disease through high-throughput sequencing
Geng, H., Shu, S., Dong, J., Li, H., Xu, C., Han, Y., Hu, J., Han, Y., Yang, R., & Cheng, N. (2018) · Medicine · doi:10.1097/md.0000000000011743 · Cited by 34 · see citing works
Analysis of the intestinal microbiome in colorectal cancer
Gataullin, B. I., Гатауллин, И. Г., Nga, N. T., et al. (2021) · Kazan medical journal · doi:10.17816/kmj2021-185 · Cited by 1 · see citing works

Authors: Shen, X. J., Rawls, J. F., Randall, T. A., Burcall, L., Mpande, C., Jenkins, N., Jovov, B., Abdo, Z., Sandler, R. S., & Keku, T. O.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Idaho (US)
Corresponding author: Keku, Temitope O.
ORCID: Shen, Xiang Jun
Rawls, John F.
Randall, Thomas A.
Abdo, Zaid
Sandler, Robert S.
Keku, Temitope O.
Venue: Gut Microbes
Publisher: Informa UK Limited
Published: 2010-05
Volume: 1
Issue: 3
Pages: 138-147
ISSN: 1949-0976 (ISSN-L)
1949-0984
DOI: 10.4161/gmic.1.3.12360
PMC: PMC2927011
OpenAlex: W2013354102
Cited by: 418
References: 62
Citations by year: 2026: 7 · 2025: 13 · 2024: 26 · 2023: 37 · 2022: 32 · 2021: 27 · 2020: 26 · 2019: 34 · 2018: 28 · 2017: 25 · 2016: 30 · 2015: 37 · 2014: 23 · 2013: 37 · 2012: 21
FWCI: 9.50
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Gut Microbes (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health (DK-34987, CA106991)
National Cancer Institute (R01CA136887, K01CA093654, P50CA106991, R01CA044684, R01-CA-44684)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081426, P30‐DK34987, P30DK034987, K01DK073695)
National Institute of Environmental Health Sciences (P30ES010126)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: colorectal adenoma, colonic mucosa, adherent bacteria, gut microbiota, bacterial community composition, colorectal cancer risk, Proteobacteria, Bacteroidetes, Firmicutes, Faecalibacterium, Dorea, Bacteroides, Coprococcus, bacterial diversity, 16S rRNA gene sequencing
MeSH terms: Adenoma, Bacteria, Bacterial Adhesion, Colon, Cross-Sectional Studies, DNA, Bacterial, Humans, Intestinal Mucosa, Male, Middle Aged, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S, Colorectal Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks