The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes
Abstract
High‐volume endurance exercise (END) improves glycaemic control in type 2 diabetes (T2D) but many individuals cite ‘lack of time’ as a barrier to regular participation. High‐intensity interval training (HIT) is a time‐efficient method to induce physiological adaptations similar to END, but little is known regarding the effect of HIT in T2D. Using continuous glucose monitoring (CGM), we examined the 24‐h blood glucose response to one session of HIT consisting of 10 × 60 s cycling efforts at ∼90% maximal heart rate, interspersed with 60 s rest. Seven adults with T2D underwent CGM for 24‐h on two occasions under standard dietary conditions: following acute HIT and on a non‐exercise control day (CTL). HIT reduced hyperglycaemia measured as proportion of time spent above 10 mmol/l (HIT: 4.5 ± 4.4 vs. CTL: 15.2 ± 12.3%, p = 0.04). Postprandial hyperglycaemia, measured as the sum of post‐meal areas under the glucose curve, was also lower after HIT vs. CTL (728 ± 331 vs. 1142 ± 556 mmol/l·9 h, p = 0.01). These findings highlight the potential for HIT to improve glycaemic control in T2D.
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In the citing paper
“we and others [8,60], have demonstrated that it is possible, after a familiarization period, for previously untrained persons to successfully perform this kind of training”
From High-Intensity Interval Resistance Training (HIRT) influences resting energy expenditure and respiratory ratio in non-dieting individuals (2012) · cites this paper as [60]
In the citing paper
“For example, time-efficient HIIT has been shown to rapidly improve glucose control in individuals with prediabetes [13, 14] and T2D [12, 15].”
From High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes (2015) · cites this paper as [15]
Citations
Cites
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Snowling, N. J., & Hopkins, W. G. (2006) · Diabetes Care · doi:10.2337/dc06-1317 · Cited by 813
Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., Jung, M. E., & Gibala, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00921.2011 · Cited by 787
Self-citationGibala, M. J., & McGee, S. L. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318168ec1f · Cited by 682
Self-citationColberg (2010) · doi:10.2337/dc10-1548 · Cited by 656
Postprandial Glucose Regulation and Diabetic Complications
Ceriello, A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.19.2090 · Cited by 362 · cited 2×
“Postprandial hyperglycaemia is a major contributor to type 2 diabetes (T2D)-related complications, including cardiovascular disease [1].”
BackgroundStatistical Tools to Analyze Continuous Glucose Monitor Data
Clarke, W. L., & Kovatchev, B. P. (2009) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2008.0138 · Cited by 248
Low-Intensity Exercise Reduces the Prevalence of Hyperglycemia in Type 2 Diabetes
MANDERS, R. J. F., VAN DIJK, J.-W. M., & VAN LOON, L. J. C. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181b3b16d · Cited by 180
The effect of intense exercise on postprandial glucose homeostasis in type II diabetic patients
Larsen, J. J. S., Dela, F., Madsbad, S., & Galbo, H. (1999) · Diabetologia · doi:10.1007/s001250051440 · Cited by 112
Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes
PRAET, S. F., MANDERS, R. J., LIEVERSE, A. G., KUIPERS, H., STEHOUWER, C. D., KEIZER, H. A., & VAN LOON, L. J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000235352.09061.1d · Cited by 85
Exercise-Induced Alterations in Muscle Lipid Metabolism Improve Insulin Sensitivity
Horowitz, J. F. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318156e084 · Cited by 68
Tjønna, A. E., Rognmo, Ø., Bye, A., Stølen, T., & Wisløff, U. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181fb4809 · Cited by 50
Manders, R., van Dijk, J.-W., Hartgens, F., & van Loon, L. (2009) · Surrey Research Insight Open Access (The University of Surrey) · Cited by 1
Cited by
Sorted by citations
Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991
Self-citationKANALEY, J. A., COLBERG, S. R., CORCORAN, M. H., MALIN, S. K., RODRIGUEZ, N. R., CRESPO, C. J., KIRWAN, J. P., & ZIERATH, J. R. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002800 · Cited by 931
Gillen, J. B., & Gibala, M. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0187 · Cited by 552
Self-citationJung, M. E., Bourne, J. E., & Little, J. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114541 · Cited by 331
Self-citationAmerican Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Eichorst, B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s005 · Cited by 305
Metadata
- Authors
- Gillen, J. B., Little, J. P., Punthakee, Z., Tarnopolsky, M. A., Riddell, M. C., & Gibala, M. J.
- Affiliations
- McMaster University (CA)
- York University (CA)
- Corresponding author
- Gibala, M. J.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2012-02-20
- Volume
- 14
- Issue
- 6
- Pages
- 575-577
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W1987329229
- Cited by
- 272
- References
- 13
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 21 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 23 · 2017: 21 · 2016: 22 · 2015: 20 · 2014: 18 · 2013: 39 · 2012: 6
- FWCI
- 21.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Diabetes Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- high-intensity interval training, type 2 diabetes, postprandial blood glucose, hyperglycemia, glycemic control, acute exercise, continuous glucose monitoring, time-efficient exercise, endurance exercise
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Hyperglycemia, Male, Middle Aged, Time Factors, Blood Glucose Self-Monitoring, Exercise, Prevalence, Postprandial Period
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