Low-Intensity Exercise Reduces the Prevalence of Hyperglycemia in Type 2 Diabetes
Abstract
INTRODUCTION: Glycemic instability is a severely underestimated problem in type 2 diabetes treatment. Therapeutic targets should aim to reduce postprandial blood glucose excursions. Exercise prescription can effectively improve glucose homeostasis and reduce the risk of cardiovascular complications. AIM: To assess the impact of a single, isoenergetic bout of low- (LI) and high-intensity (HI) exercise on the prevalence of hyperglycemia throughout the subsequent 24-h postexercise period in longstanding type 2 diabetes patients. METHODS: Nine sedentary, male type 2 diabetes patients (age = 57 +/- 2 yr, body mass index = 29.0 +/- 1.0 kg x m(-2), Wmax = 2.2 +/- 0.2 W x kg(-1) body weight) were selected to participate in a randomized crossover study. Subjects performed an isoenergetic bout of endurance-type exercise for 60 min at 35% Wmax (LI) or 30 min at 70% Wmax (HI) or no exercise at all (NE). Thereafter, glycemic control was assessed during the subsequent 24-h postexercise period by continuous glucose monitoring under strict dietary standardization but otherwise free-living conditions. RESULTS: Average 24-h glucose concentrations were reduced after the LI exercise bout (7.8 +/- 0.9 mmol x L(-1)) when compared with the control experiment (9.4 +/- 0.8 mmol x L(-1); P < 0.05). The HI exercise bout did not significantly lower mean glucose concentrations (8.7 +/- 0.7 mmol x L(-1); P = 0.14). Hyperglycemia was prevalent for as much as 35% +/- 9% throughout the day (NE). A single bout of exercise reduced the prevalence of hyperglycemia by 50% +/- 4% (P < 0.05) and 19% +/- 9% (P = 0.13) in the LI and HI exercise experiments, respectively. CONCLUSIONS: A single bout of LI, as opposed to HI, exercise substantially reduces the prevalence of hyperglycemia throughout the subsequent 24-h postexercise period in longstanding type 2 diabetes patients.
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Light exercise for 60 minutes daily reduced hyperglycemic episodes within 24 hours by about 50% compared with no exercise, while high-intensity cycling for 30 minutes daily did not significantly reduce hyperglycemic episodes.
“Similarly, light exercise for 60 minutes daily reduced hyperglycemic episodes within 24 hours by around 50% compared to no exercise, while high intensity cycling for 30 minutes daily did not have a significant reduction in number of hyperglycemic episodes compared to the same control.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [89]
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The Impact of Physical Activity in Patients With Type 2 Diabetes
Bassin, S. R., & Srinath, R. (2025) · American Journal of Lifestyle Medicine · doi:10.1177/15598276231180541 · Cited by 17 · see citing works
- Authors
- MANDERS, R. J. F., VAN DIJK, J.-W. M., & VAN LOON, L. J. C.
- Affiliations
- Maastricht University Medical Centre (NL)
- ORCID
- MANDERS, RALPH J. F.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2010-02
- Volume
- 42
- Issue
- 2
- Pages
- 219-225
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1999780357
- Cited by
- 180
- References
- 39
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 20 · 2015: 16 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- type 2 diabetes, low-intensity exercise, high-intensity exercise, hyperglycemia, glycemic control, endurance exercise, continuous glucose monitoring, postprandial blood glucose, single bout exercise, sedentary patients
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Male, Middle Aged, Netherlands, Physical Endurance, Exercise, Cross-Over Studies, Glycemic Index
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