Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
Open accessAbstract
Glucose is the primary energetic substrate of the brain, and measurements of its metabolism are the basis of major functional cerebral imaging methods. Contrary to the general view that neurons are fueled solely by glucose in proportion to their energetic needs, recent in vitro and ex vivo analyses suggest that glucose preferentially feeds astrocytes. However, the cellular fate of glucose in the intact brain has not yet been directly observed. We have used a real-time method for measuring glucose uptake in astrocytes and neurons in vivo in male rats by imaging the trafficking of the nonmetabolizable glucose analog 6-deoxy-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-aminoglucose (6-NBDG) using two-photon microscopy. During resting conditions we found that astrocytes and neurons both take up 6-NBDG at the same rate in the barrel cortex of the rat. However, during intense neuronal activity triggered by whisker stimulation, astrocytes rapidly accelerated their uptake, whereas neuronal uptake remained almost unchanged. After the stimulation period, astrocytes returned to their preactivation rates of uptake paralleling the neuronal rate of uptake. These observations suggest that glucose is taken up primarily by astrocytes, supporting the view that functional imaging experiments based on glucose analogs extraction may predominantly reflect the metabolic activity of the astrocytic network.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
6-NBDG cannot be phosphorylated by hexokinase because the 6 position is occupied by the fluorophore.
“The first study (Chuquet et al., 2010) used the fluorescent glucose analogue 6-NBDG; because it cannot be phosphorylated by hexokinase (given that the 6 position was already occupied by the fluorophore), this analogue’s accumulation may not correspond with the actual rate of glucose utilization, and it has been shown in some cases to correlate negatively with glucose utilization (DiNuzzo et al., 2”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
Two recent in vivo studies monitoring glucose analogue accumulation in somatosensory cortex during whisker stimulation used two different glucose analogues and obtained opposite results.
“Two recent in vivo studies monitored glucose analogue accumulation in somatosensory cortex during whisker stimulation; they used two different glucose analogues and obtained opposite results.”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
6-NBDG accumulation may not correspond with the actual rate of glucose utilization.
“The first study (Chuquet et al., 2010) used the fluorescent glucose analogue 6-NBDG; because it cannot be phosphorylated by hexokinase (given that the 6 position was already occupied by the fluorophore), this analogue’s accumulation may not correspond with the actual rate of glucose utilization, and it has been shown in some cases to correlate negatively with glucose utilization (DiNuzzo et al., 2”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
Upon whisker stimulation in anesthetized rats, 6-NBDG uptake into both cell types tended to increase, though only significantly for astrocytes.
“Baseline accumulation of the analogue into astrocytes and neurons was similar; upon whisker stimulation in anesthetized rats, uptake into both cell types tended to increase, though only significantly for astrocytes (Chuquet et al., 2010).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
Baseline accumulation of 6-NBDG into astrocytes and neurons was similar.
“Baseline accumulation of the analogue into astrocytes and neurons was similar; upon whisker stimulation in anesthetized rats, uptake into both cell types tended to increase, though only significantly for astrocytes (Chuquet et al., 2010).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In vivo measurements of stimulated glucose analog uptake have given conflicting results.
“In vivo measurements to learn which cell type shows greater stimulated uptake of glucose analogs have given conflicting results (Chuquet et al., 2010; Lundgaard et al., 2015)”
From Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake (2017) · cites this paper as Chuquet et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 861 · see citing works
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb03919.x · Cited by 807 · see citing works
Activity-dependent regulation of energy metabolism by astrocytes: an update
Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805 · see citing works
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. D., & Helmchen, F. (2004) · Nature Methods · doi:10.1038/nmeth706 · Cited by 784 · see citing works
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750 · see citing works
Astrocyte Responses to CNS Injury
Norenberg, M. D. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199405000-00001 · Cited by 589 · see citing works
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587 · see citing works
Chung, S., Li, X., & Nelson, S. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00659-1 · Cited by 530 · cited 2× · see citing works
“sponses to sustained whisker deflection (Chung et al., 2002) we”
BackgroundAlmeida, A., Almeida, J., Bolaños, J. P., & Moncada, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261560998 · Cited by 423 · see citing works
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408 · see citing works
Patel, A. B., de Graaf, R. A., Mason, G. F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501703102 · Cited by 343 · see citing works
Contreras, D., & Steriade, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021133 · Cited by 329 · see citing works
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293 · see citing works
Loaiza, A., Porras, O. H., & Barros, L. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07337.2003 · Cited by 254 · see citing works
Sibson, N. R., Mason, G. F., Shen, J., Cline, G. W., Herskovits, A. Z., Wall, J. E. M., Behar, K. L., Rothman, D. L., & Shulman, R. G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00074.x · Cited by 239 · see citing works
Neuroglial Metabolism in the Awake Rat Brain: CO2Fixation Increases with Brain Activity
Öz, G., Berkich, D. A., Henry, P., Xu, Y., LaNoue, K. F., Hutson, S. M., & Rolf Gruetter, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3564-04.2004 · Cited by 215 · see citing works
Yamada, K., Nakata, M., Horimoto, N., Saito, M., Matsuoka, H., & Inagaki, N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908048199 · Cited by 191 · see citing works
Mangia, S., Simpson, I. A., Vannucci, S. J., & Carruthers, A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06003.x · Cited by 189 · see citing works
Bioenergetics of cerebral ischemia: A cellular perspective
Hertz, L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.023 · Cited by 187 · see citing works
Schmidt, M. (2009) · Frontiers in Neuroenergetics · doi:10.3389/neuro.14.001.2009 · Cited by 171 · see citing works
Magistretti, P. J., & Pellerin, L. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34449.x · Cited by 159 · see citing works
The redox switch/redox coupling hypothesis
Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146 · see citing works
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139 · see citing works
Computer simulations of neuron-glia interactions mediated by ion flux
Somjen, G. G., Kager, H., & Wadman, W. J. (2008) · Journal of Computational Neuroscience · doi:10.1007/s10827-008-0083-9 · Cited by 130 · see citing works
Lopes‐Cardozo, M., Larsson, O. M., & Schousboe, A. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13039.x · Cited by 124 · see citing works
Nehlig, A., Wittendorp-Rechenmann, E., & Dao Lam, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000128533.84196.d8 · Cited by 111 · see citing works
Asymmetric transport of a fluorescent glucose analogue by human erythrocytes
Speizer, L. A., Haugland, R. P., & Kutchai, H. C. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90476-6 · Cited by 100 · see citing works
Cellular pathways of energy metabolism in the brain: Is glucose used by neurons or astrocytes?
Nehlig, A., & Coles, J. A. (2007) · Glia · doi:10.1002/glia.20376 · Cited by 92 · see citing works
The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies.
Magistretti, P. J., & Pellerin, L. (1996) · PubMed · Cited by 89 · see citing works
Cruz, N. F., Lasater, A., Zielke, H. R., & Dienel, G. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02935.x · Cited by 88 · see citing works
Deciphering neuron-glia compartmentalization in cortical energy metabolism
Jolivet, R. (2009) · Frontiers in Neuroenergetics · doi:10.3389/neuro.14.004.2009 · Cited by 87 · see citing works
Barros, L. F., Courjaret, R. J., Jakoby, P., Loaiza, A., Lohr, C., & Deitmer, J. W. (2008) · Glia · doi:10.1002/glia.20820 · Cited by 83 · see citing works
Determinants of Deoxyglucose Uptake in Cultured Astrocytes: The Role of the Sodium Pump
Brookes, N., & Yarowsky, P. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb05438.x · Cited by 77 · see citing works
Fluorometric Determination of Glucose Utilization in Neurons <i>in Vitro</i> and <i>in Vivo</i>
Itoh, Y., Abe, T., Takaoka, R., & Tanahashi, N. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000127661.07591.de · Cited by 72 · see citing works
Wyss, M. T., Weber, B., Treyer, V., Heer, S., Pellerin, L., Magistretti, P. J., & Buck, A. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.86 · Cited by 44 · see citing works
Flow cytometric analysis of glucose transport by rat brain cells
Aller, C. B., Ehmann, S., Gilman‐Sachs, A., & Snyder, A. K. (1997) · Cytometry · doi:10.1002/(sici)1097-0320(19970301)27:3 · Cited by 22 · see citing works
McCasland, J. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(96)00063-5 · Cited by 18 · see citing works
Regional differences in glucose transport in the mouse hippocampus
Shimada, M., Kawamoto, S., Hirose, Y., Nakanishi, M., Watanabe, H., & Watanabe, M. (1994) · The Histochemical Journal · doi:10.1007/bf02388435 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298 · see citing works
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285 · see citing works
Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., Chow, A., O’Connor, S. T. F., Li, S., Chin, A. R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3094 · Cited by 1,118 · see citing works
Brain Glucose Metabolism: Integration of Energetics with Function.
Dienel, G. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 806 · see citing works
Pellerin, L., & Magistretti, P. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.149 · Cited by 726 · see citing works
Methylglyoxal, the dark side of glycolysis
Allaman, I., Bélanger, M., & Magistretti, P. J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00023 · Cited by 551 · see citing works
Glucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558 · see citing works
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Newman, L. A., Korol, D. L., & Gold, P. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028427 · Cited by 473 · see citing works
Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake
Díaz-García, C. M., Mongeon, R., Lahmann, C., Koveal, D., Zucker, H., & Yellen, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.021 · Cited by 466 · see citing works
“In vivomeasurements to learn which cell type shows greater stimulated uptake of glucose analogs have given conflicting results (Chuquet et al., 2010; Lundgaard et al., 2015), perhaps because the fluorescent glucose derivatives used are substantially different from glucose in structure and size;…”
In Vivo Evidence for Lactate as a Neuronal Energy Source
Wyss, M. T., Jolivet, R., Buck, A., Magistretti, P. J., & Weber, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0415-11.2011 · Cited by 438 · see citing works
Targeting LDH enzymes with a stiripentol analog to treat epilepsy
Sada, N., Lee, S., Katsu, T., Otsuki, T., & Inoue, T. (2015) · Science · doi:10.1126/science.aaa1299 · Cited by 413 · see citing works
Immune cell regulation of glia during CNS injury and disease
Greenhalgh, A. D., David, S., & Bennett, F. C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0263-9 · Cited by 398 · see citing works
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7807 · Cited by 381 · see citing works
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
Yellen, G. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803152 · Cited by 371 · see citing works
“The first study (Chuquet et al., 2010) used the fluorescent glucose analogue 6-NBDG; because it cannot be phosphorylated by hexokinase (given that the 6 position was already occupied by the fluorophore), this analogue’s accumulation may not correspond with the actual rate of glucose utilization, and it has been shown…”
BackgroundInfluentialAstrocyte Biomarkers in Alzheimer’s Disease
Carter, S. F., Herholz, K., Rosa-Neto, P., Pellerin, L., Nordberg, A., & Zimmer, E. R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.11.006 · Cited by 355 · see citing works
Metabolic signaling by lactate in the brain
Barros, L. F. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.002 · Cited by 326 · see citing works
Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works
Astrocyte glycogen and lactate: New insights into learning and memory mechanisms
Alberini, C. M., Cruz, E., Descalzi, G., Bessières, B., & Gao, V. (2017) · Glia · doi:10.1002/glia.23250 · Cited by 286 · see citing works
Falkowska, A., Gutowska, I., Goschorska, M., Nowacki, P., Chlubek, D., & Baranowska-Bosiacka, I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125939 · Cited by 277 · see citing works
Emerging role for astroglial networks in information processing: from synapse to behavior
Pannasch, U., & Rouach, N. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.004 · Cited by 251 · see citing works
Fan, Z., Aman, Y., Ahmed, I., Chetelat, G., Landeau, B., Ray Chaudhuri, K., Brooks, D. J., & Edison, P. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.016 · Cited by 212 · see citing works
Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203 · see citing works
The Astrocyte: Powerhouse and Recycling Center
Weber, B., & Barros, L. F. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020396 · Cited by 195 · see citing works
Bittner, C. X., Valdebenito, R., Ruminot, I., Loaiza, A., Larenas, V., Sotelo-Hitschfeld, T., Moldenhauer, H. J., Martín, A. S., Gutiérrez, R., Zambrano, M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5311-10.2011 · Cited by 186 · see citing works
Fueling and Imaging Brain Activation
Dienel, G. A. (2012) · ASN NEURO · doi:10.1042/an20120021 · Cited by 175 · see citing works
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease
Price, B. R., Johnson, L. A., & Norris, C. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101335 · Cited by 173 · see citing works
Dienel, G. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24015 · Cited by 168 · see citing works
Age-dependent rescue by simvastatin of Alzheimer’s disease cerebrovascular and memory deficits
Tong, X.-K., Lecrux, C., & Hamel, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0169-12.2012 · Cited by 160 · see citing works
Frontiers in Optical Imaging of Cerebral Blood Flow and Metabolism
Devor, A., Sakadžić, S., Srinivasan, V. J., Yaseen, M. A., Nizar, K., Saisan, P. A., Tian, P., Dale, A. M., Vinogradov, S. A., Franceschini, M. A., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.195 · Cited by 154 · see citing works
Barros, L. F., & Weber, B. (2018) · The Journal of Physiology · doi:10.1113/jp274944 · Cited by 154 · see citing works
Wu, A., Lee, D., & Xiong, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713398 · Cited by 152 · see citing works
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect
Demetrius, L., Magistretti, P. J., & Pellerin, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2014.00522 · Cited by 142 · see citing works
Metabolic and inflammatory adaptation of reactive astrocytes: role of PPARs
Iglesias, J., Morales, L., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9833-2 · Cited by 137 · see citing works
Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection
Bélanger, M., Yang, J.-Y., Petit, J.-M., Laroche, T., Magistretti, P. J., & Allaman, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1249-11.2011 · Cited by 137 · see citing works
Harrison, N. A., Cooper, E., Dowell, N. G., Keramida, G., Voon, V., Critchley, H. D., & Cercignani, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.023 · Cited by 129 · see citing works
Steinman, M. Q., Gao, V., & Alberini, C. M. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2016.00010 · Cited by 122 · see citing works
Lactate as a biomarker for sleep
Naylor, E., Aillon, D. V., Barrett, B. S., Wilson, G. S., Johnson, D. A., Johnson, D. A., Harmon, H. P., Gabbert, S., & Petillo, P. A. (2012) · SLEEP · doi:10.5665/sleep.2072 · Cited by 112 · see citing works
Neurons rely on glucose rather than astrocytic lactate during stimulation
Díaz‐García, C. M., & Yellen, G. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24374 · Cited by 107 · see citing works
Jakoby, P., Schmidt, E. M., Ruminot, I., Gutierrez, R., Barros, L. F., & Deitmer, J. W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs309 · Cited by 107 · see citing works
Datson, N. A., van den Oever, J. M. E., Korobko, O. B., Magariños, A. M., de Kloet, E. R., & McEwen, B. S. (2013) · Endocrinology · doi:10.1210/en.2012-2233 · Cited by 105 · see citing works
Tadi, M., Allaman, I., Lengacher, S., Grenningloh, G., & Magistretti, P. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141568 · Cited by 106 · see citing works
Unraveling the complex metabolic nature of astrocytes
Bouzier-Sore, A.-K., & Pellerin, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00179 · Cited by 134 · see citing works
Jolivet, R., Coggan, J. S., Allaman, I., & Magistretti, P. J. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004036 · Cited by 105 · see citing works
Brix, B., Mesters, J. R., Pellerin, L., & Jöhren, O. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0879-12.2012 · Cited by 103 · see citing works
The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity
Calì, C., Tauffenberger, A., & Magistretti, P. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00082 · Cited by 101 · see citing works
Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity
Karagiannis, A., Gallopin, T., Lacroix, A., Plaisier, F., Piquet, J., Geoffroy, H., Hepp, R., Naudé, J., Gac, B. L., Egger, R., et al. (2021) · eLife · doi:10.7554/elife.71424 · Cited by 102 · see citing works
Newington, J. T., Harris, R. A., & Cumming, R. C. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/234572 · Cited by 101 · see citing works
Díaz‐García, C. M., Lahmann, C., Martínez‐François, J. R., Li, B., Koveal, D., Nathwani, N., Rahman, M., Keller, J. P., Marvin, J. S., Looger, L. L., et al. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24433 · Cited by 97 · see citing works
Lourenço, C. F., Ledo, A., Barbosa, R. M., & Laranjinha, J. A. N. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.026 · Cited by 99 · see citing works
Regenold, W. T., Pratt, M., Nekkalapu, S., Shapiro, P. S., Kristián, T., & Fiskum, G. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.018 · Cited by 96 · see citing works
Henn, R. E., Noureldein, M. H., Elzinga, S. E., Kim, B., Savelieff, M. G., & Feldman, E. L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105766 · Cited by 97 · see citing works
Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
Fernandez, A. M., Hernández-Garzón, E., Pérez‐Domper, P., Pérez‐Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Sáiz, Á., García‐Guerra, L., Pose‐Utrilla, J., et al. (2016) · Diabetes · doi:10.2337/db16-0861 · Cited by 94 · see citing works
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle
Petit, J.-M., & Magistretti, P. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.007 · Cited by 92 · see citing works
Mangia, S., DiNuzzo, M., Giove, F., Carruthers, A., Simpson, I. A., & Vannucci, S. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.29 · Cited by 92 · see citing works
Kreft, M., Bak, L. K., Waagepetersen, H. S., & Schousboe, A. (2012) · ASN Neuro · doi:10.1042/an20120007 · Cited by 88 · see citing works
Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair
Hart, C. G., & Karimi‐Abdolrezaee, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24922 · Cited by 85 · see citing works
Kim, W. H., Lee, J., Jung, D., & Williams, D. R. (2012) · Sensors · doi:10.3390/s120405005 · Cited by 83 · see citing works
Virtuoso, A., Giovannoni, R., Luca, C. D., Gargano, F., Cerasuolo, M., Maggio, N., Lavitrano, M., & Papa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073301 · Cited by 80 · see citing works
A Metabolic Landscape for Maintaining Retina Integrity and Function
Viegas, F., & Neuhauss, S. C. F. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.656000 · Cited by 81 · see citing works
Vezzoli, E., Calì, C., De Roo, M., Ponzoni, L., Sogne, E., Gagnon, N., Francolini, M., Braida, D., Sala, M., Muller, D., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz226 · Cited by 79 · see citing works
Papadopoulos, P., Rosa‐Neto, P., Rochford, J. M., & Hamel, É. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068612 · Cited by 75 · see citing works
Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism
Dong, J., Chen, X., Cui, M., Yu, X., Pang, Q., & Sun, J.-P. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9742-4 · Cited by 65 · see citing works
Rodriguez‐Rodriguez, P., Almeida, Á., & Bolaños, J. P. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.005 · Cited by 74 · see citing works
McDougal, D. H., Hermann, G. E., & Rogers, R. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2855-11.2011 · Cited by 71 · see citing works
The insulin‐like growth factor I receptor regulates glucose transport by astrocytes
Hernández-Garzón, E., Fernandez, A. M., Pérez‐Alvarez, A., Genı́s, L., Bascuñana, P., de la Rosa, R. F., Delgado, M., Pozo, M. A., Moreno, E., McCormick, P. J., et al. (2016) · Glia · doi:10.1002/glia.23035 · Cited by 70 · see citing works
Wang, Y., Li, P., Xu, Y., Feng, L., Fang, Y., Song, G., Li, X., Zhu, Z., Wang, W., Mei, Q., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03303-4 · Cited by 71 · see citing works
Hertz, L. (2011) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2011.04.013 · Cited by 70 · see citing works
Ruminot, I., Schmälzle, J., Leyton, B., Barros, L. F., & Deitmer, J. W. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17737012 · Cited by 70 · see citing works
Functional magnetic resonance imaging
Buchbinder, B. R. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53485-9.00004-0 · Cited by 69 · see citing works
Lactate Supply Overtakes Glucose When Neural Computational and Cognitive Loads Scale Up
Dembitskaya, Y., Piette, C., Siaume‐Perez, S., Berry, H., Magistretti, P. J., & Venance, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212004119 · Cited by 68 · see citing works
Small is fast: astrocytic glucose and lactate metabolism at cellular resolution
Barros, L. F., Martín, A. S., Sotelo-Hitschfeld, T., Lerchundi, R., Fernández‐Moncada, I., Ruminot, I., Gutiérrez, R., Valdebenito, R., Ceballo, S., Alegría, K., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00027 · Cited by 61 · see citing works
Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice
Harris, R. A., Lone, A., Lim, H., Martínez, F. M., Frame, A. K., Scholl, T. J., & Cumming, R. C. (2019) · eNeuro · doi:10.1523/eneuro.0389-18.2019 · Cited by 60 · see citing works
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Elsayed, M., & Magistretti, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00468 · Cited by 59 · see citing works
Sonnay, S., Poirot, J., Just, N., Clerc, A., Rolf Gruetter, A., Rainer, G., & Duarte, J. M. N. (2017) · Glia · doi:10.1002/glia.23259 · Cited by 57 · see citing works
Single-cell imaging tools for brain energy metabolism: a review
Martín, A. S., Sotelo-Hitschfeld, T., Lerchundi, R., Fernández‐Moncada, I., Ceballo, S., Valdebenito, R., Baeza‐Lehnert, F., Alegría, K., Contreras‐Baeza, Y., Garrido-Gerter, P., et al. (2014) · Neurophotonics · doi:10.1117/1.nph.1.1.011004 · Cited by 57 · see citing works
Metabolism navigates neural cell fate in development, aging and neurodegeneration
Traxler, L., Lagerwall, J., Eichhorner, S., Stefanoni, D., D’Alessandro, A., & Mertens, J. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048993 · Cited by 57 · see citing works
Castro, V., Skowrońska, M., Lombardi, J., He, J., Seth, N., Velichkovska, M., & Toborek, M. J. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17720816 · Cited by 56 · see citing works
Current technical approaches to brain energy metabolism
Barros, L. F., Bolaños, J. P., Bonvento, G., Bouzier‐Sore, A., Brown, A. M., Hirrlinger, J., Kasparov, S., Kirchhoff, F., Murphy, A. N., Pellerin, L., et al. (2017) · Glia · doi:10.1002/glia.23248 · Cited by 56 · see citing works
Neuron-oligodendroglia interactions: Activity-dependent regulation of cellular signaling
Thornton, M. A., & Hughes, E. G. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134916 · Cited by 54 · see citing works
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 52 · see citing works
Robertson, J. M. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.09.021 · Cited by 50 · see citing works
Regulation of memory – From the adrenal medulla to liver to astrocytes to neurons
Gold, P. E. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.12.012 · Cited by 48 · see citing works
Müller, M. S., Fouyssac, M., & Taylor, C. W. (2018) · Current Biology · doi:10.1016/j.cub.2018.08.060 · Cited by 47 · see citing works
Near‐critical GLUT1 and Neurodegeneration
Barros, L. F., Martín, A. S., Ruminot, I., Sandoval, P. Y., Fernández‐Moncada, I., Baeza‐Lehnert, F., Arce‐Molina, R., Contreras‐Baeza, Y., Cortés‐Molina, F., Galaz, A., et al. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23998 · Cited by 47 · see citing works
Sleep and Wake Affect Glycogen Content and Turnover at Perisynaptic Astrocytic Processes
Bellesi, M., de Vivo, L., Koebe, S. D., Tononi, G., & Cirelli, C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00308 · Cited by 46 · see citing works
Modulation of multiple memory systems: From neurotransmitters to metabolic substrates
Gold, P. E., Newman, L. A., Scavuzzo, C. J., & Korol, D. L. (2013) · Hippocampus · doi:10.1002/hipo.22182 · Cited by 45 · see citing works
Yang, W., Pang, D., Chen, M., Du, C., Jia, L., Wang, L., He, Y., Jiang, W., Luo, L., Yu, Z., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.022 · Cited by 45 · see citing works
Mazuel, L., Blanc, J., Repond, C., Bouchaud, V., Raffard, G., Déglon, N., Bonvento, G., Pellerin, L., & Bouzier-Sore, A.-K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174990 · Cited by 44 · see citing works
Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders
Mitra, S., Banik, A., Saurabh, S., Maulik, M., & Khatri, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0998-21.2022 · Cited by 44 · see citing works
High-resolution in vivo optical imaging of stroke injury and repair
Sakadžić, S., Lee, J., Boas, D. A., & Ayata, C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.044 · Cited by 44 · see citing works
Gerkau, N. J., Rakers, C., Petzold, G. C., & Rose, C. R. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23995 · Cited by 44 · see citing works
Colucci, A. C. M., Tassinari, I. D., Loss, E. D. S., & de Fraga, L. S. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.06.022 · Cited by 42 · see citing works
DiNuzzo, M., Giove, F., Maraviglia, B., & Mangia, S. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2048-0 · Cited by 42 · see citing works
Gold, P. E., & Korol, D. L. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00116 · Cited by 41 · see citing works
Glucose and lactate metabolism in the awake and stimulated rat: a 13C-NMR study
Sampol, D., Ostrofet, E., Jobin, M., Raffard, G., Sanchez, S., Bouchaud, V., Franconi, J., Bonvento, G., & Bouzier‐Sore, A. (2013) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2013.00005 · Cited by 39 · see citing works
Reprogramming energetic metabolism in Alzheimer's disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.033 · Cited by 37 · see citing works
Qi, G., Mi, Y., & Yin, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01531 · Cited by 37 · see citing works
Interferon-alpha-Induced changes in NODDI predispose to the development of fatigue
Dowell, N. G., Bouyagoub, S., Tibble, J., Voon, V., Cercignani, M., & Harrison, N. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.040 · Cited by 36 · see citing works
- Authors
- Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-11-10
- Volume
- 30
- Issue
- 45
- Pages
- 15298-15303
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2997269
- OpenAlex
- W2009966509
- Cited by
- 217
- References
- 42
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 13 · 2023: 18 · 2022: 12 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 23 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC009947)
- National Institute of Neurological Disorders and Stroke (R01NS034994)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, neurons, glucose uptake, somatosensory cortex, barrel cortex, whisker stimulation, neuronal activation, two-photon microscopy, brain energy metabolism, functional neuroimaging
- MeSH terms
- Analysis of Variance, Animals, Astrocytes, Biological Transport, Glucose, Male, Neurons, Somatosensory Cortex, Vibrissae, Rats, Sprague-Dawley, Microscopy, Fluorescence, Multiphoton, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
