Cited by 133Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeuroscience and Neuropharmacology Research

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The α4β2α5 nicotinic cholinergic receptor in rat brain is resistant to up‐regulation by nicotine in vivo

Mao, Danyan, Perry, David C., Yasuda, Robert P., Wolfe, Barry B., Kellar, Kenneth J.·2008·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2007.05011.x

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Abstract

We used immunoprecipitation with subunit-specific antibodies to examine the distribution of heteromeric neuronal nicotinic acetylcholine receptors (nAChRs) that contain the alpha5 subunit in the adult rat brain. Among the regions of brain we surveyed, the alpha5 subunit is associated in approximately 37% of the nAChRs in the hippocampus, approximately 24% of the nAChRs in striatum, and 11-16% of the receptors in the cerebral cortex, thalamus, and superior colliculus. Sequential immunoprecipitation assays demonstrate that the alpha5 subunit is associated with alpha4beta2* nAChRs exclusively. Importantly, in contrast to alpha4beta2 nAChRs, which are increased by 37-85% after chronic administration of nicotine, the alpha4beta2alpha5 receptors are not increased by nicotine treatment. These data thus indicate that the alpha4beta2alpha5 nAChRs in rat brain are resistant to up-regulation by nicotine in vivo, which suggests an important regulatory role for the alpha5 subunit. To the extent that nicotine-induced up-regulation of alpha4beta2 nAChRs is involved in nicotine addiction, the resistance of the alpha4beta2alpha5 subtype to up-regulation may have important implications for nicotine addiction.

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Authors: Mao, D., Perry, D. C., Yasuda, R. P., Wolfe, B. B., & Kellar, K. J.
Affiliations: Georgetown University (US)
George Washington University (US)
Corresponding author: Kellar, Kenneth J.
ORCID: Perry, David C.
Kellar, Kenneth J.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2007-09-26
Volume: 104
Issue: 2
Pages: 446-456
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2007.05011.x
OpenAlex: W1976309270
Cited by: 133
References: 57
Citations by year: 2026: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 14
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R01DA015767, DA015767, DA 12976)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nicotinic acetylcholine receptors, alpha5 subunit, receptor up-regulation, nicotine, receptor subunit composition, hippocampus, striatum, cerebral cortex, thalamus, superior colliculus, nicotine dependence, rat brain
MeSH terms: Animals, Binding Sites, Brain, Nicotine, Pyridines, Receptors, Nicotinic, Up-Regulation, Rats, Sprague-Dawley, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic, Protein Subunits, Immunoprecipitation, Rats

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The α4β2α5 nicotinic cholinergic receptor in rat brain is resistant to up‐regulation by nicotine in vivo

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