Nicotinic alteration of decision-making
Abstract
Addiction to nicotine is characterized by impulses, urges and lack of self-control towards cigarettes. A key element in the process of addiction is the development of habits oriented towards nicotine consumption that surpass flexible systems as a consequence of a gradual adaptation to chronic drug exposure. However, the long-term effects of nicotine on brain circuits also induce wide changes in decision-making processes, affecting behaviors unrelated to cigarettes. This review aims at providing an update on the implications of nicotine on general decision-making processes, with an emphasis on impulsivity and risk-taking. As impulsivity is a rather ambiguous behavioral trait, we build on economic and normative theories to better characterize these nicotine-induced alterations in decision-making. Nonetheless, experimental data are sparse and often contradictory. We will discuss how the latest findings on the neurobiological basis of choice behavior may help disentangling these issues. We focus on the role of nicotine acetylcholine receptors and their different subunits, and on the spatio-temporal dynamics (i.e. diversity of the neural circuits, short- and long-term effects) of both endogenous acetylcholine and nicotine action. Finally, we try to link these neurobiological results with neuro-computational models of attention, valuation and action, and of the role of acetylcholine in these decision processes. This article is part of the Special Issue entitled 'The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition'.
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ACh provides complex regulation of reward and motivation behaviors through its actions on dopamine circuitry.
“ACh provides a complex regulation of reward and motivation behaviors through its actions on dopamine (DA) circuitry [68–72].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [70]
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“Moreover, both chronic nicotine exposure and withdrawal durably affect dopamine release in the striatum (Rahman et al., 2004; Zhang et al., 2013), probably affecting a wide range of decision processes.”
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Self-citationNicotine consumption is regulated by a human polymorphism in dopamine neurons
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Acute nicotine increases both impulsive choice and behavioural disinhibition in rats
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Neurophysiology of Nicotine Addiction
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Prefrontal neuromodulation by nicotinic receptors for cognitive processes
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Imbalanced Decision Hierarchy in Addicts Emerging from Drug-Hijacked Dopamine Spiraling Circuit
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Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors
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Nicotine and the behavioral mechanisms of intertemporal choice
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Self-citationCost–Benefit Decision Circuitry
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High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses
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Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior
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A Preliminary Investigation on Smokeless Tobacco Use and Its Cognitive Effects Among Athletes
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Vape and Aviate: Electronic-Cigarette Use and Misuse in Naval Aviation
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Optogenetic Control of Mammalian Ion Channels with Chemical Photoswitches
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Mesolimbic Neural Response Dynamics Predict Future Individual Alcohol Drinking in Mice
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Minimal Circuit Model of Reward Prediction Error Computations and Effects of Nicotinic Modulations
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Acetylcholine reflects uncertainty during hidden state inferencePreprint
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From Genes to Behavior: Mouse Models of the Cholinergic System
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- Authors
- Naudé, J., Dongelmans, M., & Faure, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 96
- Issue
- Pt B
- Pages
- 244-254
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2053373709
- Cited by
- 39
- References
- 167
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- ATIP programme
- Agence Nationale pour la Recherche
- Neuropole de Recherche Francilien (NeRF) of Ile de France
- Bettencourt Schueller Foundation
- Ecole des Neurosciences de Paris (ENP)
- Fondation pour la recherche Médicale (Equipe FRM (DEQ20130326488)
- Fondation pour le cerveau (FRC et les Rotariens de France, “Espoir en tête” 2012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, decision-making, impulsivity, risk-taking, nicotine dependence, acetylcholine receptor, acetylcholine, choice behavior, neurocomputational model, valuation, attention, neural circuits
- MeSH terms
- Acetylcholine, Animals, Brain, Decision Making, Humans, Impulsive Behavior, Neurons, Nicotine, Receptors, Nicotinic, Risk-Taking, Tobacco Use Disorder, Nicotinic Agonists, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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