Cited by 39Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

Nicotinic alteration of decision-making

Naudé, Jérémie, Dongelmans, Malou, Faure, Philippe·2015·Neuropharmacology

Abstract

Addiction to nicotine is characterized by impulses, urges and lack of self-control towards cigarettes. A key element in the process of addiction is the development of habits oriented towards nicotine consumption that surpass flexible systems as a consequence of a gradual adaptation to chronic drug exposure. However, the long-term effects of nicotine on brain circuits also induce wide changes in decision-making processes, affecting behaviors unrelated to cigarettes. This review aims at providing an update on the implications of nicotine on general decision-making processes, with an emphasis on impulsivity and risk-taking. As impulsivity is a rather ambiguous behavioral trait, we build on economic and normative theories to better characterize these nicotine-induced alterations in decision-making. Nonetheless, experimental data are sparse and often contradictory. We will discuss how the latest findings on the neurobiological basis of choice behavior may help disentangling these issues. We focus on the role of nicotine acetylcholine receptors and their different subunits, and on the spatio-temporal dynamics (i.e. diversity of the neural circuits, short- and long-term effects) of both endogenous acetylcholine and nicotine action. Finally, we try to link these neurobiological results with neuro-computational models of attention, valuation and action, and of the role of acetylcholine in these decision processes. This article is part of the Special Issue entitled 'The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition'.

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Crossref · 10.1016/j.neuropharm.2014.11.021

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Authors
Naudé, J., Dongelmans, M., & Faure, P.
Affiliations
Centre National de la Recherche Scientifique (FR)
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2015-09
Volume
96
Issue
Pt B
Pages
244-254
ISSN
0028-3908 (ISSN-L)
OpenAlex
W2053373709
Cited by
39
References
167
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Centre National de la Recherche Scientifique
  • ATIP programme
  • Agence Nationale pour la Recherche
  • Neuropole de Recherche Francilien (NeRF) of Ile de France
  • Bettencourt Schueller Foundation
  • Ecole des Neurosciences de Paris (ENP)
  • Fondation pour la recherche Médicale (Equipe FRM (DEQ20130326488)
  • Fondation pour le cerveau (FRC et les Rotariens de France, “Espoir en tête” 2012)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
nicotine, decision-making, impulsivity, risk-taking, nicotine dependence, acetylcholine receptor, acetylcholine, choice behavior, neurocomputational model, valuation, attention, neural circuits
MeSH terms
Acetylcholine, Animals, Brain, Decision Making, Humans, Impulsive Behavior, Neurons, Nicotine, Receptors, Nicotinic, Risk-Taking, Tobacco Use Disorder, Nicotinic Agonists, Dopaminergic Neurons

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