Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.

Raybuck, Jonathan D.; Portugal, George S.; Lerman, Caryn; Gould, Thomas J.

doi:10.1037/a0012601

Cited by 62Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationMemory and Neural Mechanisms

Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.

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Raybuck, Jonathan D., Portugal, George S., Lerman, Caryn, Gould, Thomas J.·2008·Behavioral Neuroscience

DOI 10.1037/a0012601PMC PMC2683368

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Abstract

Varenicline, a partial agonist for a4ss2 nicotinic acetylcholine receptors (nAChRs) and full agonist for a7 nAChRs, has been approved for the treatment of smoking cessation. Although recent clinical trials support the efficacy of varenicline for managing global nicotine withdrawal symptoms and for smoking cessation, its effects on animal models of specific withdrawal-associated behaviors have not been tested. The present study evaluated the effects of varenicline on contextual fear conditioning and its effects on nicotine (6.3 mg/kg/day) withdrawal-induced deficits in contextual fear conditioning. Varenicline (0.01, 0.1, 1.0 mg/kg) had no effect on contextual fear conditioning when administered alone, but (0.1 mg/kg) prevented nicotine withdrawal-associated deficits in contextual fear conditioning. These data demonstrate, for the first time, that varenicline reverses nicotine withdrawal-induced deficits in an animal model and suggest that varenicline may be effective at treating nicotine withdrawal-associated deficits in learning and memory.

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Both sazetidine-A and varenicline ameliorate cognitive withdrawal symptoms.
“both sazetidine-A and varenicline ameliorate cognitive with- drawal symptoms (Raybuck et al, 2008; Rezvani et al, 2011)”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Raybuck et al, 2008
Nicotine, varenicline, and bupropion reduce nicotine withdrawal-associated deficits in hippocampus-dependent learning.
“It has been shown that nicotine, varenicline, and bupropion ameliorate nicotine withdrawal-associated deficits in hippocampus-dependent learning (Davis et al., 2005; Portugal and Gould, 2007; Raybuck et al., 2008).”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Raybuck et al., 2008

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Authors: Raybuck, J. D., Portugal, G. S., Lerman, C., & Gould, T. J.
Affiliations: Temple University (US)
Abramson Cancer Center (US)
ORCID: Raybuck, Jonathan D.
Lerman, Caryn
Gould, Thomas J.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2008
Volume: 122
Issue: 5
Pages: 1166-1171
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/a0012601
PMC: PMC2683368
OpenAlex: W1980507550
Cited by: 62
References: 77
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 12 · 2013: 7 · 2012: 8
FWCI: 1.92
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (DA017949 TG)
National Cancer Institute/National Institute on Drug Abuse (P5084718 PI)
National Institutes of Health (T32DA07237)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: varenicline, nicotine withdrawal, contextual fear conditioning, learning deficits, memory impairment, nicotinic acetylcholine receptors, smoking cessation, C57BL/6 mice
MeSH terms: Varenicline, Animals, Behavior, Animal, Benzazepines, Conditioning, Psychological, Disease Models, Animal, Dose-Response Relationship, Drug, Fear, Learning Disabilities, Male, Mice, Inbred C57BL, Quinoxalines, Tobacco Use Disorder, Nicotinic Agonists, Freezing Reaction, Cataleptic, Mice

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Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.

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