Cited by 115Sleep and Wakefulness ResearchMemory and Neural MechanismsNeural dynamics and brain function

Learning-Dependent, Transient Increase of Activity in Noradrenergic Neurons of Locus Coeruleus during Slow Wave Sleep in the Rat: Brain Stem–Cortex Interplay for Memory Consolidation?

Eschenko, Oxana, Sara, Susan J.·2008·Cerebral Cortex

Abstract

Memory consolidation during sleep is regaining attention due to a wave of recent reports of memory improvements after sleep or deficits after sleep disturbance. Neuromodulators have been proposed as possible players in this putative off-line memory processing, without much experimental evidence. We recorded neuronal activity in the rat noradrenergic nucleus locus coeruleus (LC) using chronically implanted movable microelectrodes while monitoring the behavioral state via electrocorticogram and online video recording. Extracellular recordings of physiologically identified noradrenergic neurons of LC were made in freely behaving rats for 3 h before and after olfactory discrimination learning. On subsequent days, if LC recording remained stable, additional learning sessions were made within the olfactory discrimination protocol, including extinction, reversals, learning new odors. Contrary to the long-standing dogma about the quiescence of noradrenergic neurons of LC, we found a transient increase in LC activity in trained rats during slow wave sleep (SWS) 2 h after learning. The discovery of learning-dependent engagement of LC neurons during SWS encourages exploration of brain stem-cortical interaction during this delayed phase of memory consolidation and should bring new insights into mechanisms underlying memory formation.

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Crossref · 10.1093/cercor/bhn020

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  • A specific sleep-related window of increased LC burst activity about 120 min after learning of odor-reward associations has been identified in rats.

    “Moreover, a specific sleep-related window of increased LC burst activity ϳ120 min after learning of odor-reward associations has been identified in rats (356).”

    From About Sleep's Role in Memory (2013) · cites this paper as [356]

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Authors
Eschenko, O., & Sara, S. J.
Affiliations
Centre National de la Recherche Scientifique (FR)
Venue
Cerebral Cortex
Published
2008-03-04
Volume
18
Issue
11
Pages
2596-2603
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2146958231
Cited by
115
References
40
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 13 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 11 · 2012: 8
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
locus coeruleus, noradrenergic neurons, slow-wave sleep, memory consolidation, olfactory discrimination learning, sleep-dependent memory processing, neuromodulation, sleep spindles
MeSH terms
Animals, Cerebral Cortex, Discrimination Learning, Electrodes, Implanted, Electrophysiology, Extinction, Psychological, Locus Coeruleus, Male, Memory, Neuronal Plasticity, Norepinephrine, Olfactory Pathways, Reversal Learning, Sleep, Rats, Sprague-Dawley, Rats

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