Epigenetic mechanisms in anti-cancer actions of bioactive food components—the implications in cancer prevention
Open accessAbstract
The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in the absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails and regulation by non‐coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies have provided evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one‐carbon metabolism, such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine and methionine, affect DNA methylation by regulating the levels of S‐adenosyl‐L‐methionine, a methyl group donor, and S‐adenosyl‐L‐homocysteine, which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non‐coding RNAs such as vitamin D, which recruits histone acetylases, or resveratrol, which activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro‐RNAs. As epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti‐cancer therapy.
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Many bioactive molecules in food and herbs, in addition to folate, can influence epigenetics and have been proposed as potential chemopreventative agents.
“There are many bioactive molecules present in food and herbs, in addition to folate, that are capable of influencing epigenetics and that have been touted as potential chemopreventative agents. Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Stefanska et al., 2012
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Vitamin D for health: a global perspective
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“Epigenetic modification refers to heritable changes in gene expression that are not mediated by alterations in DNA sequence.(52) This hypothesis, first articulated by Barker et al,(53) postulated that in utero epigenetic fetal programming (as a result of environmental events during pregnancy) induced specific genes an…”
Influence of Metabolism on Epigenetics and Disease
Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920 · see citing works
“Examples include various B vitamins, retinoic acid, vitamin D3, reservatrol, genistein and daidzein, epigallocatechin-3-gallate (EGCG), and curcumin (Gerhauser, 2013; Stefanska et al., 2012).”
Potential Health Benefits of Olive Oil and Plant Polyphenols
Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656 · see citing works
“There are many studies pointing out an essential role of polyphenolic compounds as derived from vegetables, fruits, or herbs in the regulation of epigenetic modifications, resulting in the antiproliferative protection [61].”
BackgroundSeven sirtuins for seven deadly diseases ofaging
Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 380 · see citing works
“L-homocysteine, an inhibitor of DNA methylation enzymes [587].”
BackgroundGene methylation in gastric cancer
Qu, Y., Dang, S., & Hou, P. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.002 · Cited by 374 · see citing works
Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms
Sinha, D., Sarkar, N., Biswas, J., & Bishayee, A. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.11.001 · Cited by 263 · see citing works
One-carbon metabolism and epigenetics
Friso, S., Udali, S., Santis, D. D., & Choi, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.007 · Cited by 251 · see citing works
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
Mahmoud, A. M., & Ali, M. M. (2019) · Nutrients · doi:10.3390/nu11030608 · Cited by 249 · see citing works
Natural Products for the Management and Prevention of Breast Cancer
Mitra, S., & Dash, R. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/8324696 · Cited by 249 · see citing works
VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases
Shoshan‐Barmatz, V., Shteinfer‐Kuzmine, A., & Verma, A. (2020) · Biomolecules · doi:10.3390/biom10111485 · Cited by 232 · see citing works
Grady, W. M., Yu, M., & Markowitz, S. D. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.058 · Cited by 217 · see citing works
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
Gerhauser, C. (2012) · Topics in Current Chemistry · doi:10.1007/128_2012_360 · Cited by 194 · see citing works
“The available information on the topic has been summarized in several recent review articles [20–36, 121, 122, 203, 204].”
BackgroundMartin, C. R., Zhang, Y., Tonelli, C., & Petroni, K. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120142 · Cited by 167 · see citing works
Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition
Shankar, S., Kumar, D., & Srivastava, R. K. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.002 · Cited by 162 · see citing works
Epigenetic modifications of gene expression by lifestyle and environment
Abdul, Q. A., Yu, B. P., Chung, H. Y., Jung, H. A., & Choi, J. S. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0973-3 · Cited by 157 · see citing works
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
Anwar, M. A., Disi, S. S. A., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00050 · Cited by 140 · see citing works
Childhood Leukemia and Primary Prevention
Whitehead, T. P., Metayer, C., Wiemels, J. L., Singer, A. W., & Miller, M. D. (2016) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2016.08.004 · Cited by 136 · see citing works
“Maternal intake of folate and other nutrients involved in one-carbon metabolism may influence childhood leukemia risk due to the importance of these nutrients for DNA synthesis and repair, chromosomal integrity, and epigenetic processes that determine gene expression and influence cancer risk, including histone modifi…”
BackgroundGenetic and epigenetic factors influencing vitamin D status
Bahrami, A., Sadeghnia, H. R., Tabatabaeizadeh, S., Bahrami‐Taghanaki, H., Behboodi, N., Esmaily, H., Ferns, G. A., Ghayour‐Mobarhan, M., & Avan, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26216 · Cited by 138 · see citing works
Curcumin: An epigenetic regulator and its application in cancer
Ming, T., Tao, Q., Tang, S., Zhao, H., Yang, H., Liu, M., Ren, S., & Xu, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113956 · Cited by 141 · see citing works
Epigenetics and cancer metabolism
Johnson, C., Warmoes, M. O., Shen, X., & Locasale, J. W. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.043 · Cited by 106 · see citing works
“Bioactive food compounds such as polyphenols found in plants are claimed to regulate DNMT expression and activity, increase HAT activity, and activate sirtuins to elicit antioxidative, anti-tumorigenic, and anti-metastatic properties [72,73].”
BackgroundEpigenetic Effects of Green Tea Polyphenols in Cancer
Henning, S. M., Wang, P., Carpenter, C. L., & Heber, D. (2013) · Epigenomics · doi:10.2217/epi.13.57 · Cited by 105 · see citing works
Phytochemistry and Pharmacology of Phyllanthus niruri L.: A Review
Kaur, N., Kaur, B., & Sirhindi, G. (2017) · Phytotherapy Research · doi:10.1002/ptr.5825 · Cited by 109 · see citing works
Zeitelhofer, M., Adzemovic, M. Z., Gómez-Cabrero, D., Bergman, P., Hochmeister, S., N’diaye, M., Paulson, A., Ruhrmann, S., Almgren, M., Tegner, J. N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615783114 · Cited by 102 · see citing works
Aziz, N. A. A., & Jalil, A. M. M. (2019) · Foods · doi:10.3390/foods8030096 · Cited by 103 · see citing works
“There are many studies pointing out an essential role of polyphenolic compounds as derived from vegetables, fruits, or herbs in the regulation of epigenetic modifications, resulting in the antiproliferative protection [64].”
BackgroundPresent and future of anti-ageing epigenetic diets
Bacalini, M. G., Friso, S., Olivieri, F., Pirazzini, C., Giuliani, C., Capri, M., Santoro, A., Franceschi, C., & Garagnani, P. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.006 · Cited by 94 · see citing works
“(Stefanska et al., 2012), while the effects of folate administration on ageing are less well characterized.”
DNA Damage, DNA Repair and Cancer
Bernstein, C., Anil, R., Nfonsam, V. N., & Bernstei, H. (2013) · InTech eBooks · doi:10.5772/53919 · Cited by 94 · see citing works
“Dietary agents also have been shown to affect DNA methylation or histone modification by numerous path‐ ways [13].”
BackgroundHistone Modifications as an Intersection Between Diet and Longevity
Molina‐Serrano, D., Kyriakou, D., & Kirmizis, A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00192 · Cited by 91 · see citing works
Necrosis-Driven Systemic Immune Response Alters SAM Metabolism through the FOXO-GNMT Axis
Obata, F., Kuranaga, E., Tomioka, K., Ming, M., Takeishi, A., Chen, C., Soga, T., & Miura, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.046 · Cited by 92 · see citing works
Dietary polyphenols and chromatin remodeling
Russo, G. L., Vastolo, V., Ciccarelli, M., Albano, L., Macchia, P. E., & Ungaro, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1062353 · Cited by 88 · see citing works
“The effects of resveratrol on cancer prevention and treatment via the interference on epigenetic changes have been largely documented (Link et al., 2010, Stefanska et al., 2012).”
BackgroundWang, B., Sun, J., Li, X., Zhou, Q., Bai, J., Shi, Y., & Le, G. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.07.016 · Cited by 80 · see citing works
“[1] Stefanska B, Karlic H, Varga F, Fabianowska-Majewska K, Haslberger A.”
BackgroundEpigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
Khan, M. A., Tania, M., & Fu, J. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.007 · Cited by 78 · see citing works
Nutritive vitamins as epidrugs
Nur, S. M., Rath, S., Ahmad, V., Ahmad, A., Ateeq, B., & Khan, M. I. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1712674 · Cited by 78 · see citing works
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure
Badary, O. A., Hamza, M. S., & Tikamdas, R. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s308863 · Cited by 76 · see citing works
A comprehensive review on high -fat diet-induced diabetes mellitus: an epigenetic view
Prasad, M., Rajagopal, P., Devarajan, N., Veeraraghavan, V. P., Palanisamy, C. P., Cui, B., Patil, S., & Jayaraman, S. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109037 · Cited by 76 · see citing works
Chemopreventive role of food-derived proteins and peptides: A review
Hernández‐Ledesma, B., & Hsieh, C. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1057632 · Cited by 75 · see citing works
“By modulating and improving physiological functions, these bioactive peptides may provide new therapeutic applications for the prevention and/or treatment of chronic diseases, such as cancer (Suarez-Jimenez et al., 2012).”
BackgroundPhytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation
Pop, S., Enciu, A., Ţârcomnicu, I., Gille, E., & Tănase, C. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09627-x · Cited by 73 · see citing works
Lubecka, K., Kaufman‐Szymczyk, A., Stefañska, B., Cebula‐Obrzut, B., Smolewski, P., & Fabianowska‐Majewska, K. (2015) · Lifestyle Genomics · doi:10.1159/000439111 · Cited by 72 · see citing works
Self-citationThe contributions of cancer cell metabolism to metastasis
Pascual, G., Domínguez, D., & Benitah, S. A. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.032920 · Cited by 71 · see citing works
“Increasing data supports the importance of diet in the crosstalk between metabolism and epigenetic regulation (Stefanska et al., 2012), and the extent to which epigenomic changes occur in metastasis (Wong et al., 2017).”
Remely, M., Stefañska, B., Lovrečić, L., Magnet, U., & Haslberger, A. G. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000180 · Cited by 70 · see citing works
Self-citationFabianowska‐Majewska, K., Kaufman‐Szymczyk, A., Szymanska-Kolba, A., Jakubik, J., Majewski, G., & Lubecka, K. (2021) · Nutrients · doi:10.3390/nu13020332 · Cited by 69 · see citing works
“The literature data indicated that more than 100 genes have been hypermethylated in primary breast tumors and breast cancer cell lines, i.e., PTEN (Phosphatase And Tensin Homolog), RARB (Retinoic Acid Receptor Beta), APC (APC Regulator Of WNT Signaling Pathway), CDKN2A (P16; Cyclin Dependent Kinase Inhibitor 2A), CDH1…”
BackgroundInfluentialSelf-citationEpigenetic modifications from arsenic exposure: A comprehensive review
Chakraborty, A., Ghosh, S., Biswas, B., Pramanik, S., Nriagu, J. O., & Bhowmick, S. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151218 · Cited by 69 · see citing works
Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming
Mathias, P. C. D. F., Elmhiri, G., de Oliveira, J. C., Delayre‐Orthez, C., Barella, L. F., Tófolo, L. P., Fabricio, G. S., Chango, A., & Abdennebi‐Najar, L. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0654-7 · Cited by 68 · see citing works
Caradonna, F., Consiglio, O., Luparello, C., & Gentile, C. (2020) · Nutrients · doi:10.3390/nu12061748 · Cited by 67 · see citing works
“Their ability to alter epigenetic patterns may depend on direct interaction with the enzymes responsible for adding or removing epigenetic marks or, indirectly, on the regulation of the expression of genes that encode proteins implicated in the epigenetic machinery [51].”
BackgroundFarhan, M., Ullah, M. F., Faisal, M., Farooqı, A. A., Sabitaliyevich, U. Y., Biersack, B., & Ahmad, A. (2019) · Medicines · doi:10.3390/medicines6010024 · Cited by 64 · see citing works
“BRCA-1 Breast Reduced promotor DNA methylation in vitro [36] Reduced promotor DNA methylation in vivo [37] NRF2 Breast Reduced promotor DNA methylation [38]”
BackgroundAnticancer Natural Compounds as Epigenetic Modulators of Gene Expression
Ratovitski, E. A. (2017) · Current Genomics · doi:10.2174/1389202917666160803165229 · Cited by 64 · see citing works
“Potential anticancer natural compounds have been shown causing epigenetic alterations and facilitating the inhibition of cancer growth [83-97, 100].”
BackgroundInfluentialEpigenetic therapy as a novel approach in hepatocellular carcinoma
Anestopoulos, I., Voulgaridou, G.-P., Georgakilas, A. G., Franco, R., Pappa, A., & Panayiotidis, M. I. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.005 · Cited by 61 · see citing works
Rising Rates of Colorectal Cancer among Younger Iranians: Is Diet to Blame?
Arani, S. H., & Kerachian, M. A. (2017) · Current Oncology · doi:10.3747/co.23.3226 · Cited by 61 · see citing works
Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health
Ionescu, V., Popa, A., Alexandru, A., Manole, E., Neagu, M., & Pop, S. (2021) · Antioxidants · doi:10.3390/antiox10121893 · Cited by 62 · see citing works
Rawson, J. B., Sun, Z., Dicks, E. L., Daftary, D., Parfrey, P. S., Green, R. C., Gallinger, S., McLaughlin, J. R., Wang, P., Knight, J. A., et al. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.711418 · Cited by 58 · see citing works
“Vitamin D is an emerging protective factor for CRC (22) that mediates expression of numerous cancer genes through conventional binding of the internalized vitamin D receptor to gene promoters or through epigenetic mediation of these gene promoters including histone modification and gene methylation (23).”
BackgroundBenninghoff, A. D., Hintze, K. J., Monsanto, S. P., Rodriguez, D. M., Hunter, A., Phatak, S., Pestka, J. J., Wettere, A. J. V., & Ward, R. E. (2020) · Nutrients · doi:10.3390/nu12020544 · Cited by 58 · see citing works
“Choline, folate, and vitamins B6 and B12 are essential in cellular biosynthetic pathways due to their roles as donors of methyl groups for one carbon-metabolism [58], and consequently influence DNA methylation, cycling of s-adenosylmethionine, activity of DNA methyltransferases and miRNAs with both oncogenic and tumor…”
BackgroundDietary components as epigenetic-regulating agents against cancer
Chang, L., & Yu, Y. (2016) · Biomedicine · doi:10.7603/s40681-016-0002-8 · Cited by 57 · see citing works
“Epigenetic modifications include DNA methylation, histone modification (acetylation, methylation, and phosphorylation), and microRNA expression, playing a critical role in many cellular processes [1-4].”
BackgroundInfluentialCardiovascular health and cancer risk associated with plant based diets: An umbrella review
Capodici, A., Mocciaro, G., Gori, D., Landry, M. J., Masini, A., Sanmarchi, F., Fiore, M., Coa, A. A., Castagna, G., Gardner, C. D., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300711 · Cited by 62 · see citing works
Coffee consumption and cardiometabolic health: a comprehensive review of the evidence
Ungvari, Z., & Kunutsor, S. (2024) · GeroScience · doi:10.1007/s11357-024-01262-5 · Cited by 51 · see citing works
“Bioactive compounds, such as chlorogenic acid and caffeic acid, have been shown to modulate DNA methylation patterns [184–186].”
BackgroundUpdates on the Effect of Mycotoxins on Male Reproductive Efficiency in Mammals
Khoury, D. E., Fayjaloun, S., Nassar, M., Sahakian, J., & Aad, P. Y. (2019) · Toxins · doi:10.3390/toxins11090515 · Cited by 58 · see citing works
“In addition to the different regulatory mechanisms, epigenetic patterns can also be altered directly on the DNA by bioactive compounds or indirectly by affecting the enzymes that catalyze DNA methylation and histone modification [157,158], which would explain the diversity of epigenetic responses.”
BackgroundLubecka, K., Kaufman‐Szymczyk, A., Stefañska, B., & Fabianowska‐Majewska, K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.103 · Cited by 55 · see citing works
Self-citationBingula, R., Dupuis, C., Pichon, C., Berthon, J., Filaire, M., Pigeon, L., & Filaire, E. (2016) · Journal of Oncology · doi:10.1155/2016/8162952 · Cited by 56 · see citing works
Grady, W. M. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.006 · Cited by 52 · see citing works
Interplay Between Inflammation and Epigenetic Changes in Cancer
Maiuri, A. R., & O’Hagan, H. M. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.09.002 · Cited by 50 · see citing works
“Whereas DNMT1, a maintenance methyltransferase, methylates hemimethylated DNA in order to maintain the methylation pattern initiated by the de novo DNMTs.”
BackgroundInfluentialCancer Chemotherapy via Natural Bioactive Compounds
Pathak, K., Pathak, M. P., Saikia, R., Gogoi, U., Sahariah, J. J., Zothantluanga, J. H., Samanta, A., & Das, A. (2022) · Current Drug Discovery Technologies · doi:10.2174/1570163819666220331095744 · Cited by 50 · see citing works
Song, L., Du, A., Xiong, Y., Jiang, J., Zhang, Y., Tian, Z., & Yan, H. (2016) · Tumor Biology · doi:10.1007/s13277-016-5367-5 · Cited by 49 · see citing works
“A number of studies have demonstrated that certain natural bioactive compounds found in food and herbs can modulate the expression of tumor suppressor genes [3].”
BackgroundTargeted metabolomics for serum amino acids and acylcarnitines in patients with lung cancer
Ni, J., Xu, L., Li, W., Zheng, C., & Wu, L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7533 · Cited by 48 · see citing works
“Methionine may affect DNA methylation by regulating the levels of S-adenosyl-L-methionine, a methyl group donor, in addition to S-adenosyl-L-homocysteine, an inhibitor of enzymes catalyzing the DNA methylation reaction (46).”
BackgroundLiaudanskas, M., Viškelis, P., Jakštas, V., Raudonis, R., Kviklys, D., Milašius, A., & Janulis, V. (2014) · Journal of Chemistry · doi:10.1155/2014/542121 · Cited by 48 · see citing works
Effects of Dietary Components on Cancer of the Digestive System
Zanini, S., Marzotto, M., Giovinazzo, F., Bassi, C., & Bellavite, P. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.732126 · Cited by 47 · see citing works
“Several nutrients have been shown to affect DNA methylation, target histone modification and regulate oncogenic and tumor suppressor micro-RNAs (Stefanska et al., 2012).”
BackgroundImpact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer
Dammann, R., Richter, A. M., Jiménez, A. P., Woods, M., Küster, M. M., & Witharana, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102160 · Cited by 47 · see citing works
“A number of studies have provided evidence that several natural compounds found in food and herbs can inhibit DNMT activity or downregulate DNMT expression (Table 1) and modulate DNA methylation of tumor suppressor genes, like RASSF1A or p16/CDKNA2 [68,69].”
BackgroundDetermination of the Phenolic Composition and Antioxidant Activity of Pear Extracts
Liaudanskas, M., Zymonė, K., Viškelis, J., Klevinskas, A., & Janulis, V. (2017) · Journal of Chemistry · doi:10.1155/2017/7856521 · Cited by 46 · see citing works
Effects of Dietary Nutrients on Epigenetic Changes in Cancer
Andreescu, N. I., Puiu, M., & Niculescu, M. D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8751-1_7 · Cited by 45 · see citing works
Lactylation in cancer: metabolic mechanism and therapeutic strategies
Sui, Y., Shen, Z., Wang, Z., Feng, J., & Zhou, G. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02349-4 · Cited by 49 · see citing works
“These reversible changes enable cells to adapt and regulate gene functions in response to environmental stress [6, 7].”
Naselli, F., Belshaw, N. J., Gentile, C., Tutone, M., Tesoriere, L., Livrea, M. A., & Caradonna, F. (2015) · Lifestyle Genomics · doi:10.1159/000439382 · Cited by 41 · see citing works
Food Components in Health Promotion and Disease Prevention
Langhans, W. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02121 · Cited by 39 · see citing works
Verma, M. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328361dc70 · Cited by 38 · see citing works
Gianfredi, V., Nucci, D., Vannini, S., Villarini, M., & Moretti, M. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1359322 · Cited by 38 · see citing works
Epigenetic alterations in cancer and personalized cancer treatment
Miozzo, M. R., Vaira, V., & Sirchia, S. M. (2015) · Future Oncology · doi:10.2217/fon.14.237 · Cited by 37 · see citing works
Epigenetic regulation of mi RNA ‐cancer stem cells nexus by nutraceuticals
Ahmad, A., Li, Y., Bao, B., Kong, D., & Sarkar, F. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300528 · Cited by 37 · see citing works
Molecular mechanisms of action of Trehalose in cancer: A comprehensive review
Chaitanya, N. S. N., Devi, A., Sahu, S., & Alugoju, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118968 · Cited by 37 · see citing works
Calcagno, D. Q., Wisnieski, F., Mota, E. R. D. S., de Sousa, S. B. M., da Silva, J. M. C., Leal, M. F., Gigek, C. O., Santos, L. C., Rasmussen, L. T., de Assumpção, P. P., et al. (2019) · Epigenomics · doi:10.2217/epi-2018-0081 · Cited by 35 · see citing works
Nava, A. C., Cojoc, M., Peitzsch, C., Cirillo, G., Kurth, I., Fuessel, S., Erdmann, K., Kunhardt, D., Vittorio, O., Hampel, S., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29614 · Cited by 34 · see citing works
“A number of studies have provided evidence that some natural bioactive components of food and plants can target cancer cells by regulating different elements of the epigenetic machinery, which modulates gene expression and intracellular signaling.(31,32) Diverse tea polyphenols including catechin and its derivatives C…”
BackgroundEpigenetic reprogramming in breast cancer: From new targets to new therapies
Katz, T. A., Huang, Y., Davidson, N. E., & Jankowitz, R. C. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.923740 · Cited by 33 · see citing works
Boughanem, H., Cabrera-Mulero, A., Hernández‐Alonso, P., Clemente‐Postigo, M., Casanueva, F. F., Tinahones, F. J., Morcillo, S., Crujeiras, A. B., & Macías‐González, M. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00875-9 · Cited by 32 · see citing works
Resveratrol Inhibits Sodium/Iodide Symporter Gene Expression and Function in Rat Thyroid Cells
Giuliani, C., Bucci, I., Santo, S. D., Rossi, C., Grassadonia, A., Mariotti, M., Piantelli, M., Monaco, F., & Napolitano, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107936 · Cited by 32 · see citing works
Nutritional Epigenetic Regulators in the Field of Cancer
Schnekenburger, M., & Diederich, M. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800206-3.00018-5 · Cited by 32 · see citing works
Stefañska, B., & MacEwan, D. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13136 · Cited by 32 · see citing works
“Apart from catechol compounds that reduce intracellular SAM pools available for DNA and histone methylation, polyphenols lack a direct link with the epigenetic machineries and the mechanisms underlying their epigenetic action are yet to be determined.”
InfluentialCurcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism
Zhang, W., Cui, N., Ye, J., Yang, B., Sun, Y., & Kuang, H. (2022) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.11.003 · Cited by 31 · see citing works
Dietary macro- and micro-nutrients intake adequacy at 6th and 12th month post-bariatric surgery
Ziadlou, M., Hosseini‐Esfahani, F., Khosravi, H. M., Hosseinpanah, F., Barzin, M., Khalaj, A., & Valizadeh, M. (2020) · BMC Surgery · doi:10.1186/s12893-020-00880-y · Cited by 30 · see citing works
Shteinfer‐Kuzmine, A., Verma, A., Arif, T., Aizenberg, O., Paul, A., & Shoshan‐Barmatz, V. (2020) · IUBMB Life · doi:10.1002/iub.2407 · Cited by 31 · see citing works
Beckett, E., Martin, C., Choi, J., King, K., Niblett, S. H., Boyd, L., Duesing, K., Yates, Z. R., Veysey, M. J., & Lucock, M. D. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.06.006 · Cited by 30 · see citing works
“It is recognized thatmethyldonor diet can influence methylation status, and therefore cancer risk [33].”
BackgroundCucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer
Sikander, M., Malik, S., Chauhan, N., Κhan, P., Kumari, S., Kashyap, V. K., Khan, S., Ganju, A., Halaweish, F. T., Yallapu, M. M., et al. (2019) · Cancers · doi:10.3390/cancers11030364 · Cited by 30 · see citing works
The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link
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“Several investigations have indicated that dietary phytochemicals exhibiting anticancer characteristics are able to target disrupted cellular epigenetic systems and play crucial roles [43].”
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“Nowadays epigenetics is making an increasingly important impact in cancer research [2-4].”
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“RF has multiple protective effects with anti-oxidant, anti-aging, anti-inflammatory, and anticancer properties (Powers 2003; Stefanska et al. 2012).”
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Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress
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“Abnormal miRNA expression is driven by genetic and epigenetic factors, which are implicated in cancer occurrence and development, and this may be reversed by a variety of dietary components [72].”
Background
- Authors
- Stefanska, B., Karlic, H., Varga, F., Fabianowska‐Majewska, K., & Haslberger, A.
- Affiliations
- Hanusch Hospital (AT)
- Medical University of Lodz (PL)
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-08-22
- Volume
- 167
- Issue
- 2
- Pages
- 279-297
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC3481038
- OpenAlex
- W1753288383
- Cited by
- 200
- References
- 252
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 22 · 2018: 8 · 2017: 22 · 2016: 18 · 2015: 20 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Łódzki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- epigenetics, cancer prevention, dietary bioactive compounds, DNA methylation, histone modifications, non-coding RNA, one-carbon metabolism, S-adenosylmethionine, folic acid, resveratrol, sirtuins, histone acetyltransferase, vitamin D, microRNA, cancer therapy
- MeSH terms
- Antineoplastic Agents, Food Analysis, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Epigenesis, Genetic
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