The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Zinc in wound healing: Theoretical, experimental, and clinical aspects
Abstract
Zinc is an essential trace element in the human body and its importance in health and disease is appreciated. It serves as a cofactor in numerous transcription factors and enzyme systems including zinc‐dependent matrix metalloproteinases that augment autodebridement and keratinocyte migration during wound repair. Zinc confers resistance to epithelial apoptosis through cytoprotection against reactive oxygen species and bacterial toxins possibly through antioxidant activity of the cysteine‐rich metallothioneins. Zinc deficiency of hereditary or dietary cause can lead to pathological changes and delayed wound healing. Oral zinc supplementation may be beneficial in treating zinc‐deficient leg ulcer patients, but its therapeutic place in surgical patients needs further clarification. Topical administration of zinc appears to be superior to oral therapy due to its action in reducing superinfections and necrotic material via enhanced local defense systems and collagenolytic activity, and the sustained release of zinc ions that stimulates epithelialization of wounds in normozincemic individuals. Zinc oxide in paste bandages (Unna boot) protects and soothes inflamed peri‐ulcer skin. Zinc is transported through the skin from these formulations, although the systemic effects seem insignificant. We present here the first comprehensive account of zinc in wound management in relation to current concepts of wound bed preparation and the wound‐healing cascade. This review article suggests that topical zinc therapy is underappreciated even though clinical evidence emphasizes its importance in autodebridement, anti‐infective action, and promotion of epithelialization.
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Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5578 · Cited by 1,475
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Role of Zinc in Plasma Membrane Function
O'Dell, B. L. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1432s · Cited by 212
Causes and effects of the chronic inflammation in venous leg ulcers.
Ågren, M., Eaglstein, W., Ferguson, M., Harding, K., Moore, K., Saarialho-Kere, U., & Schultz, G. S. (2000) · Acta Dermato-Venereologica · doi:10.1080/00015555210317 · Cited by 113 · cited 1×
“MMP-3 and MMP-10 have a wide range of substrates in the wound bed.(89,93) Characteristically, MMPs are up-regulated following injury.”
BackgroundSelf-citationRaffoul, W., Far, M. S., Cayeux, M.-C., & Berger, M. M. (2006) · Nutrition · doi:10.1016/j.nut.2005.04.014 · Cited by 75
Pirot, F., Millet, J., Kalia, Y. N., & Humbert, P. (2009) · Skin Pharmacology · doi:10.1159/000211423 · Cited by 73
Zinc in epidermis and dermis in healthy subjects
Michaëlsson, G., Ljunghall, K., & Danielson, B. (1980) · Acta Dermato Venereologica · doi:10.2340/0001555560295299 · Cited by 61
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Zinc in Wound Healing Modulation
Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J. (2017) · Nutrients · doi:10.3390/nu10010016 · Cited by 643
Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems
Lee, S. R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9156285 · Cited by 458
The Role of Nutrition in Periodontal Health: An Update
Najeeb, S., Zafar, M., Khurshid, Z., Zohaib, S., & Almas, K. (2016) · Nutrients · doi:10.3390/nu8090530 · Cited by 235
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Nutrients · doi:10.3390/nu10020199 · Cited by 214
Miele, E., Shamir, R., Aloi, M., Assa, A., Braegger, C., Bronsky, J., de Ridder, L., Escher, J. C., Hojsak, I., Kolaček, S., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001896 · Cited by 191
Nazarizadeh, A., & Asri-Rezaie, S. (2016) · AAPS PharmSciTech · doi:10.1208/s12249-015-0405-y · Cited by 135
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132
Ogawa, Y., Kawamura, T., & Shimada, S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.003 · Cited by 123
Interaction of mineral salts with the skin: A literature survey
Polefka, T. G., Bianchini, R. J., & Shapiro, S. (2012) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2012.00731.x · Cited by 56
Research scholar, D. O. B., Devi, C. B., Nandakishore, T., N, S., Basar, G., Devi, N. O., Jamir, S., & Singh, M. A. (2014) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-13721823 · Cited by 28
Assessment of Mineral Pathophysiology in Patients with Diabetic Foot Ulcer
Yadav, C., Srikantiah, R. M., Manjrekar, P., Shenoy, M. T., & Chaudhury, D. (2020) · Biological Trace Element Research · doi:10.1007/s12011-019-01868-3 · Cited by 24
Efthymakis, K., & Neri, M. (2022) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2022.101954 · Cited by 23
Geletzke, A. K., Rinaldi, J. M., Phillips, B. E., Mobley, S. B., Miller, J., Dykes, T., Hollenbeak, C., Kelleher, S. L., & Soybel, D. I. (2014) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2431-y · Cited by 14
Metadata
- Authors
- Lansdown, A. B. G., Mirastschijski, U., Stubbs, N., Scanlon, E., & Ågren, M. S.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 15
- Issue
- 1
- Pages
- 2-16
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2088956282
- Cited by
- 709
- References
- 7
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- closed
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