Cited by 199Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

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Candida albicans iron acquisition within the host

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Almeida, Ricardo S., Wilson, Duncan, Hube, Bernhard·2009·FEMS Yeast Research

DOI 10.1111/j.1567-1364.2009.00570.x

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Abstract

As a commensal and opportunistic pathogen, Candida albicans possesses a range of determinants that contribute to survival, persistence and virulence. Among this repertoire of fitness and virulence attributes are iron acquisition factors and pathways, which allow fungal cells to gain this essential mineral in the iron-poor environment of the host. The aim of this review is to present the strategies used by C. albicans to exploit host iron reservoirs and their impact on C. albicans pathogenicity. Because iron in the human host is mostly linked to host proteins, pathogens such as C. albicans must possess mechanisms to gain iron from these proteins. Here, we introduce the most important groups of human proteins, including haemoglobin, transferrin, lactoferrin and ferritin, which contain iron and that are potential iron sources for invading microorganisms. We then summarize and discuss the known and proposed strategies by which C. albicans exploits or may exploit iron from host proteins and compare these with strategies from other pathogenic microorganisms.

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Authors: Almeida, R. S., Wilson, D., & Hube, B.
Affiliations: Universidade de São Paulo (BR)
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Corresponding author: Hube, Bernhard
ORCID: Almeida, Ricardo S.
Wilson, Duncan
Hube, Bernhard
Venue: FEMS Yeast Research
Publisher: Oxford University Press (OUP)
Published: 2009-11
Volume: 9
Issue: 7
Pages: 1000-1012
ISSN: 1567-1356 (ISSN-L)
1567-1364
DOI: 10.1111/j.1567-1364.2009.00570.x
OpenAlex: W2160042020
Semantic Scholar: 4b748f190f18862bde0e478cf1e0d43e77d953bd
Cited by: 199
References: 120
Citations by year: 2026: 2 · 2025: 13 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 10 · 2019: 10 · 2018: 5 · 2017: 17 · 2016: 9 · 2015: 14 · 2014: 18 · 2013: 21 · 2012: 11
FWCI: 1.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Yeast Research (publishedVersion)
PubMed (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Candida albicans, iron acquisition, fungal virulence, hemoglobin, transferrin, lactoferrin, ferritin, host-pathogen interaction, fungal pathogenicity
MeSH terms: Candida albicans, Humans, Iron, Models, Biological, Virulence

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Candida albicans iron acquisition within the host

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