Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 691

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease

Bugianesi, Elisabetta, Gentilcore, Elena, Manini, Rita, Natale, Stefania, Vanni, Ester, Villanova, Nicola, David, Ezio, Rizzetto, Mario, Marchesini, Giulio·2005·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2005.41583.x
Open this paper in CoChat — free account

Abstract

OBJECTIVES: Metformin proved useful in the treatment of nonalcoholic fatty liver disease (NAFLD), but its superiority over nutritional treatment and antioxidants has never been demonstrated. We aimed to compare the usefulness of metformin versus prescriptive diet or vitamin E. METHODS: In an open label, randomized trial, nondiabetic NAFLD patients were given metformin (2 g/day; n = 55) for 12 months. The control cases were given either vitamin E (800 IU/day; n = 28) or were treated by a prescriptive, weight-reducing diet (n = 27). Outcome measures were liver enzymes, insulin resistance (homeostasis model assessment), parameters of the metabolic syndrome, and histology. RESULTS: Aminotransferase levels improved in all groups, in association with weight loss. The effects in the metformin arm were larger (p < 0.0001), and alanine aminotransferase normalized in 56% of cases (odds ratio (OR) versus. controls, 3.11; 95% confidence interval (CI), 1.56-6.20; p= 0.0013). In multivariate analysis, metformin treatment was associated with higher rates of aminotransferase normalization, after correction for age, gender, basal aminotransferases, and change in body mass index (OR, 5.98; 95% CI, 2.05-17.45). Differences were maintained when the two control groups were separately analyzed. The distribution of positive criteria for the metabolic syndrome was reduced only in the metformin arm (p= 0.001, signed rank test). A control biopsy in 17 metformin-treated cases (14 nonresponders) showed a significant decrease in liver fat (p= 0.0004), necroinflammation, and fibrosis (p= 0.012 for both). No side effects were observed during metformin treatment. CONCLUSIONS: Metformin treatment is better than a prescriptive diet or vitamin E in the therapy of NAFLD patients receiving nutritional counseling. Limited histological data support an association between improved aminotransferases and biopsy findings, which require confirmation in a double-blind trial with appropriate statistical power based on liver histology.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1572-0241.2005.41583.x

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Research works printed but not linked: 25

  1. 10.1053/jhep.2003.50193 · DOI · Paper page
  2. Sanyal AJ, 2001, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256 · DOI · Paper page
  3. 10.1053/jhep.2003.50161 · DOI · Paper page
  4. Andersen T, 1991, J Hepatol, 12, 224, 10.1016/0168-8278(91)90942-5 · DOI · Paper page
  5. 10.1016/S0168-8278(97)80287-5 · DOI · Paper page
  6. 10.1136/gut.2003.027581 · DOI · Paper page
  7. 10.1111/j.1365-2036.2004.01888.x · DOI · Paper page
  8. 10.1053/jhep.2003.50420 · DOI · Paper page
  9. 10.1016/S0168-8278(03)00027-8 · DOI
  10. 10.1067/mpd.2000.106566 · DOI
  11. 10.1111/j.1572-0241.2003.08699.x · DOI · Paper page
  12. Vajro P, 2004, J Pediatr Gastroenterol Nutr, 38, 48, 10.1097/00005176-200401000-00012 · DOI
  13. 10.1016/j.amjgastroenterol.2003.08.001 · DOI
  14. 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S · DOI
  15. World Health Organization, 2000, WHO technical report series, 1
  16. Kris-Etherton P, 2001, Circulation, 103, 1823, 10.1161/01.CIR.103.13.1823 · DOI · Paper page
  17. Knobler H, 1999, Q J Med, 92, 73, 10.1093/qjmed/92.2.73 · DOI
  18. 10.1001/jama.285.19.2486 · DOI · Paper page
  19. 10.1111/j.1572-0241.1999.01377.x · DOI · Paper page
  20. Magalotti D, 2004, Dig Liver Dis, 36, 406
  21. 10.1046/j.1365-2036.2001.01083.x · DOI · Paper page
  22. 10.1053/jhep.2003.50229 · DOI · Paper page
  23. 10.1001/archinte.164.10.1066 · DOI · Paper page
  24. Maison P, 2001, Diabetes Care, 24, 1758, 10.2337/diacare.24.10.1758 · DOI
  25. 10.1038/sj.ijo.0801837 · DOI

Cited by

Metadata

Authors
Bugianesi, E., Gentilcore, E., Manini, R., Natale, S., Vanni, E., Villanova, N., David, E., Rizzetto, M., & Marchesini, G.
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-05
Volume
100
Issue
5
Pages
1082-1090
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1111/j.1572-0241.2005.41583.x
OpenAlex
W2039800528
Cited by
691
References
11
FWCI
37.52
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.