Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota
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Background: Previous studies suggest a link between gut microbiota and the development of ulcerative colitis (UC) and irritable bowel syndrome (IBS). Our aim was to investigate any quantitative differences in faecal bacterial compositions in UC and IBS patients compared to healthy controls, and to identify individual bacterial species that contribute to these differences. Methods: Faecal microbiota of 13 UC patients, 11 IBS patients and 22 healthy volunteers were analysed by PCR-Denaturing Gradient Gel Electrophoresis (DGGE) using universal and Bacteroides specific primers. The data obtained were normalized using in-house developed statistical method and interrogated by multivariate approaches. The differentiated bands were excised and identified by sequencing the V3 region of the 16S rRNA genes. Results: Band profiles revealed that number of predominant faecal bacteria were significantly different between UC, IBS and control group (p < 10-4). By assessing the mean band numbers in UC (37 ± 5) and IBS (39 ± 6), compared to the controls (45 ± 3), a significant decrease in bacterial species is suggested (p = 0.01). There were no significant differences between IBS and UC. Biodiversity of the bacterial species was significantly lower in UC (μ = 2.94, σ = 0.29) and IBS patients (μ = 2.90, σ = 0.38) than controls (μ = 3.25, σ = 0.16; p = 0.01). Moreover, similarity indices revealed greater biological variability of predominant bacteria in UC and IBS compared to the controls (median Dice coefficients 76.1% (IQR 70.9 - 83.1), 73.8% (IQR 67.0 - 77.5) and 82.9% (IQR 79.1 - 86.7) respectively). DNA sequencing of discriminating bands suggest that the presence of Bacteroides vulgatus, B. ovatus, B. uniformis, and Parabacteroides sp. in healthy volunteers distinguishes them from IBS and UC patients. DGGE profiles of Bacteroides species revealed a decrease of Bacteroides community in UC relative to IBS and controls. Conclusion: Molecular profiling of faecal bacteria revealed abnormalities of intestinal microbiota in UC and IBS patients, while different patterns of Bacteroides species loss in particular, were associated with UC and IBS.
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Bacteroides and Prevotella have been found to be increased in other colitis models or patients with IBD.
“We also found higher relative abundances of the genera Bacteroides and Prevotella in mice with less developed mucus, bacteria that have been found to be increased also in other colitis models or patients with IBD 39, 43.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [43]
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A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb00917.x · Cited by 49,574 · see citing works
The Mathematical Theory of Communication
Shannon, C. E., Weaver, W., & Wiener, N. (1950) · Physics Today · doi:10.1063/1.3067010 · Cited by 9,875 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Mathematical Theory of Communication
Dubitzky, W., Olaf Wolkenhauer, A., Cho, K.-H., & Yokota, H. (2013) · Springer eBooks · doi:10.1007/978-1-4419-9863-7_100015 · Cited by 3,291 · see citing works
Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis
Schroeder, K. W., Tremaine, W. J., & Ilstrup, D. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712243172603 · Cited by 3,037 · see citing works
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059 · see citing works
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works
Molecular Microbial Ecology Manual
Microbioly, N. S. I. (1996) · Springer eBooks · doi:10.1007/978-94-009-0215-2 · Cited by 1,692 · see citing works
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311 · see citing works
Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156 · see citing works
Molecular Microbial Ecology Manual
Akkermans, A. D. L., van Elsas, J. D., & de Bruijn, F. J. (1995) · Springer eBooks · doi:10.1007/978-94-011-0351-0 · Cited by 1,049 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., Taurog, J. D., Hammer, R. E., Wilson, K. H., & Sartor, R. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118878 · Cited by 833 · see citing works
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766 · see citing works
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
Epidemiology of inflammatory bowel disease
Loftus, E. V., & Sandborn, W. J. (2002) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(01)00002-4 · Cited by 542 · see citing works
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473 · see citing works
Yu, Z., & Morrison, M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.8.4800-4806.2004 · Cited by 470 · see citing works
Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
Conte, M. P., Schippa, S., Zamboni, I., Penta, M., Chiarini, F., Seganti, L., Osborn, J., Falconieri, P., Borrelli, O., & Cucchiara, S. (2006) · Gut · doi:10.1136/gut.2005.078824 · Cited by 383 · see citing works
Scanlan, P. D., Shanahan, F., O'Mahony, C., & Marchesi, J. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00312-06 · Cited by 330 · see citing works
Takaishi, H., Matsuki, T., Nakazawa, A., Takada, T., Kado, S., Asahara, T., Kamada, N., Sakuraba, A., Yajima, T., Higuchi, H., et al. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.07.016 · Cited by 325 · see citing works
BACTEROIDES OF THE HUMAN LOWER INTESTINAL TRACT
Salyers, A. A. (1984) · Annual Review of Microbiology · doi:10.1146/annurev.mi.38.100184.001453 · Cited by 309 · see citing works
Mättö, J., Maunuksela, L., Kajander, K., Palva, A., Korpela, R., Kassinen, A., & Saarela, M. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.08.009 · Cited by 301 · see citing works
A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome
Hoveyda, N., Heneghan, C., Mahtani, K. R., Perera, R., Roberts, N., & Glasziou, P. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-15 · Cited by 297 · see citing works
Rath, H. C., Wilson, K. H., & Sartor, R. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2969-2974.1999 · Cited by 276 · see citing works
Neut, C., Bulois, P., Desreumaux, P., Membré, J., Lederman, E., Gambiez, L. P., Cortot, A., Quandalle, P. A., Kruiningen, H. J. V., & Colombel, J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05613.x · Cited by 274 · see citing works
(1982) · PubMed · Cited by 251 · see citing works
Mylonaki, M., Langmead, L., Pantes, A., Johnson, F., & Rampton, D. S. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000131040.38607.09 · Cited by 241 · see citing works
Waidmann, M., Bechtold, O., Frick, J.-S., Lehr, H.-A., Schubert, S., Dobrindt, U., Loeffler, J., Bohn, E., & Autenrieth, I. B. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00672-3 · Cited by 234 · see citing works
Attar, A., Flourié, B., Rambaud, J., Franchisseur, C., Ruszniewski, P. B., & Bouhnik, Y. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70336-7 · Cited by 228 · see citing works
Analysis of bacterial bowel communities of IBD patients: What has it revealed?
Sokol, H., Lay, C., Seksik, P., & Tannock, G. W. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20392 · Cited by 220 · see citing works
Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission
Martinez, C., Antolin, M., Santos, J., Torrejon, A., Casellas, F., Borruel, N., Guarner, F., & Malagelada, J.-R. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01592.x · Cited by 208 · see citing works
Simpson, J. M., McCracken, V. J., Gaskins, H. R., & Mackie, R. I. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.11.4705-4714.2000 · Cited by 191 · see citing works
Poultry digestive microflora biodiversity as indicated by denaturing gradient gel electrophoresis
Hume, M. E., Kubena, L., Edrington, T., Donskey, C. J., Moore, R. W., Ricke, S. C., & Nisbet, D. J. (2003) · Poultry Science · doi:10.1093/ps/82.7.1100 · Cited by 159 · see citing works
Sokol, H., Lepage, P., Seksik, P., Dore, J. M., & Marteau, P. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.02600-05 · Cited by 140 · see citing works
Zoetendal, E. G., Amor, K. B., Akkermans, A. D. L., Abee, T., & de Vos, W. M. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00060 · Cited by 137 · see citing works
Alonso, C., Guilarte, M., Vicario, M., Ramos, L., Ramadan, Z., Antolín, M., Martínez, C., Rezzi, S., Saperas, E., Kochhar, S., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.036 · Cited by 128 · see citing works
Nielsen, D. S., Hønholt, S., Tano‐Debrah, K., & Jespersen, L. (2005) · Yeast · doi:10.1002/yea.1207 · Cited by 126 · see citing works
Genetics of inflammatory bowel disease: progress and prospects
Mathew, C. G. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh079 · Cited by 124 · see citing works
Mucosal cytokine network in inflammatory bowel disease
Andoh, A., Yagi, Y., Shioya, M., Nishida, A., Tsujikawa, T., & Fujiyama, Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5154 · Cited by 117 · see citing works
Hirasaki, S., Kozu, T., Yamamoto, H., Sano, Y., Yahagi, N., Oyama, T., Shimoda, T., Sugano, K., Tajiri, H., Takekoshi, T., et al. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-1 · Cited by 93 · see citing works
Multivariate techniques and their application in nutrition: a metabolomics case study
Kemsley, E. K., Gall, G. L., Dainty, J. R., Watson, A. D., Harvey, L. J., Tapp, H. S., & Colquhoun, I. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507685365 · Cited by 78 · see citing works
Self-citationKishi, D., Takahashi, I., Kai, Y., Tamagawa, H., Iijima, H., Obunai, S., Nezu, R., Ito, T., Matsuda, H., & Kiyono, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5891 · Cited by 65 · see citing works
Influence of Infant Diets on the Ecology of the Intestinal Tract of Human Flora-Associated Mice
Hentges, D. J., Marsh, W. W., Petschow, B. W., Thai, W. R., & Carter, M. K. (1992) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199202000-00005 · Cited by 59 · see citing works
Genetic determination of irritable bowel syndrome.
Hoţoleanu, C., Popp, R., Trifa, A., Nedelcu, L., & Dumitrascu, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6636 · Cited by 53 · see citing works
Saarela, M., Maukonen, J., von Wright, A., Vilpponen-Salmela, T., Patterson, A. J., Scott, K. P., Hämynen, H., & Mättö, J. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2006.09.020 · Cited by 48 · see citing works
Hudcovic, T., Kozáková, H., Kolinska, J., Štëpánková, R., Hrnčíř, T., & Tlaskalová-Hogenová, H. (2009) · Physiological Research · doi:10.33549/physiolres.931340 · Cited by 43 · see citing works
Tourlomousis, P., Kemsley, E. K., Ridgway, K. P., Toscano, M. J., Humphrey, T. J., & Narbad, A. (2009) · Microbial Ecology · doi:10.1007/s00248-009-9613-x · Cited by 36 · see citing works
Self-citationSydora, B. C., Tavernini, M. M., Doyle, J. S. G., & Fedorak, R. N. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2663-0 · Cited by 27 · see citing works
Postinfectious irritable bowel syndrome
Gwee, K. (2001) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-001-0053-z · Cited by 16 · see citing works
Pathophysiology in irritable bowel syndrome
Camilleri, M. (2001) · Drug News & Perspectives · doi:10.1358/dnp.2001.14.5.704648 · Cited by 10 · see citing works
Pimentel, M., Chow, E. J., Bonorris, G., Hallegua, D. S., Wallace, D. J., & Lin, H. C. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)83764-6 · Cited by 1 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works
Li, B., Ding, Y., Cheng, X., Sheng, D., Xu, Z., Rong, Q., Wu, Y., Zhao, H., Ji, X., & Zhang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125492 · Cited by 711 · see citing works
The composition of the gut microbiota shapes the colon mucus barrier
Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works
“The class Deltaproteobacteria contains sulphur-reducing bacteria (SRB) that are also found at higher frequencies in patients with IBD as compared to healthy individuals [41].”
Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01891.x · Cited by 425 · see citing works
Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome
Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Meerveld, B. G., & Cryan, J. F. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12490 · Cited by 396 · see citing works
Techniques used to characterize the gut microbiota: a guide for the clinician
Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385 · see citing works
Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission
Rajilić-Stojanović, M. D., Shanahan, F., Guarner, F., & de Vos, W. M. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31827fec6d · Cited by 355 · see citing works
Le Gall, G., Noor, S. O., Ridgway, K., Scovell, L., Jamieson, C., Johnson, I. T., Colquhoun, I. J., Kemsley, E. K., & Narbad, A. (2011) · Journal of Proteome Research · doi:10.1021/pr2003598 · Cited by 348 · see citing works
Self-citationIrritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Dziarski, R., Park, S. Y., Kashyap, D. R., Dowd, S. E., & Gupta, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146162 · Cited by 332 · see citing works
Role of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · see citing works
Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G. E. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.05.015 · Cited by 244 · see citing works
Irritable Bowel Syndrome, Gut Microbiota and Probiotics
Lee, B. J., & Bak, Y. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.252 · Cited by 229 · see citing works
Bruzzese, E., Callegari, M. L., Raia, V., Viscovo, S., Scotto, R., Ferrari, S., Morelli, L., Buccigrossi, V., Vecchio, A. L., Ruberto, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087796 · Cited by 217 · see citing works
Liu, S., Liu, X., Jialin, G., Yang, R., Wang, H., Sun, Y., Chen, B., & Dong, R. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c04706 · Cited by 220 · see citing works
Zhu, L., Xu, L., Zhao, S., Shen, Z., Shen, H., & Zhan, L. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10527-w · Cited by 190 · see citing works
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 181 · see citing works
Biedermann, L., Brülisauer, K., Zeitz, J., Frei, P., Scharl, M., Vavricka, S. R., Fried, M., Loessner, M. J., Rogler, G., & Schuppler, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000129 · Cited by 178 · see citing works
Lamas, B., Breyner, N. M., & Houdeau, É. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00349-z · Cited by 177 · see citing works
Henström, M., Diekmann, L., Bonfiglio, F., Hadizadeh, F., Kuech, E.-M., von Köckritz-Blickwede, M., Thingholm, L. B., Zheng, T., Assadi, G., Dierks, C., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312456 · Cited by 173 · see citing works
Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases
Zhang, M., & Yang, X.-J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i40.8905 · Cited by 165 · see citing works
Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis
Nomura, K., Ishikawa, D., Okahara, K., Ito, S., Haga, K., Takahashi, M., Arakawa, A., Shibuya, T., Osada, T., Kuwahara-Arai, K., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081749 · Cited by 150 · see citing works
The microbiota-gut-brain axis in functional gastrointestinal disorders
De Palma, G., Collins, S. M., & Bercik, P. (2014) · Gut Microbes · doi:10.4161/gmic.29417 · Cited by 157 · see citing works
Liu, B., Piao, X., Niu, W., Zhang, Q., Ma, C., Wu, T., Gu, Q., Cui, T., & Li, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01036 · Cited by 156 · see citing works
Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
Berry, D., & Reinisch, W. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.005 · Cited by 154 · see citing works
Food Starch Structure Impacts Gut Microbiome Composition
Warren, F. J., Fukuma, N. M., Mikkelsen, D., Flanagan, B. M., Williams, B. A., Lisle, A. T., Cuív, P. Ó., Morrison, M., & Gidley, M. J. (2018) · mSphere · doi:10.1128/msphere.00086-18 · Cited by 152 · see citing works
Rangel, I., Sundin, J., Fuentes, S., Repsilber, D., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13399 · Cited by 151 · see citing works
Cheng, H., Liu, J., Zhang, D., Wang, J., Tan, Y., Feng, W., & Peng, C. Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.817600 · Cited by 147 · see citing works
Fu, P., Gao, M., & Yung, K. K. L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00607 · Cited by 145 · see citing works
Microbiome: Should we diversify from diversity?
Johnson, K. V. ‐., & Burnet, P. W. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1241933 · Cited by 142 · see citing works
Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
Bennet, S., Öhman, L., & Simrén, M. (2015) · Gut and Liver · doi:10.5009/gnl14344 · Cited by 143 · see citing works
Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach?
Liao, Y., Peng, Z., Chen, L., Nussler, A. K., Liu, L., & Yang, W. Q. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.01.013 · Cited by 136 · see citing works
Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome
Zhuang, X., Tian, Z., Li, L., Zeng, Z., Chen, M., & Xiong, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01600 · Cited by 137 · see citing works
Wang, Z.-K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14805 · Cited by 132 · see citing works
Villa, C., Ward, W. E., & Comelli, E. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1010034 · Cited by 128 · see citing works
Microbial ecosystems therapeutics: a new paradigm in medicine?
Petrof, E., Claud, E. C., Gloor, G. B., & Allen‐Vercoe, E. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0039 · Cited by 124 · see citing works
Intestinal Microbiota and its Role in Irritable Bowel Syndrome (IBS)
Öhman, L., & Simrén, M. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0323-7 · Cited by 123 · see citing works
Recent developments in the pathophysiology of irritable bowel syndrome
El-Salhy, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7621 · Cited by 111 · see citing works
Tribble, G. D., Kerr, J., & Wang, B.-Y. (2013) · Future Microbiology · doi:10.2217/fmb.13.30 · Cited by 110 · see citing works
Chiu, C.-M., Huang, W.-C., Weng, S.-L., Tseng, H., Liang, C., Wang, W.-C., Yang, T., Yang, T.-L., Weng, C.-T., Chang, T., et al. (2014) · BioMed Research International · doi:10.1155/2014/906168 · Cited by 107 · see citing works
Ke, D., Zheng, J., Liu, X., Xu, X., Zhao, L., Gu, Y., Yang, R., Liu, S., Yang, S., Du, J. C., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104828 · Cited by 116 · see citing works
Schreiber, S., Panés, J., Louis, E. J., Holley, D., Buch, M., & Paridaens, K. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-108 · Cited by 107 · see citing works
Chung, C., Chang, P., Liao, C., Lee, T., Chen, Y., Lee, Y., Wu, M., Wang, H., & Ni, Y. (2015) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1116107 · Cited by 101 · see citing works
Ihekweazu, F. D., Fofanova, T. Y., Queliza, K., Nagy‐Szakal, D., Stewart, C. J., Engevik, M. A., Hultén, K. G., Tatevian, N., Graham, D. Y., Versalovic, J. A., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1560753 · Cited by 98 · see citing works
Shobeiri, P., Kalantari, A., Teixeira, A. L., & Rezaei, N. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00422-6 · Cited by 105 · see citing works
Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease
Cruz, P. P. D., Prideaux, L., Wagner, J., Ng, S. C., McSweeney, C. S., Kirkwood, C. D., Morrison, M., & Kamm, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21751 · Cited by 95 · see citing works
Sensitivity of pathogenic and commensal bacteria from the human colon to essential oils
Thapa, D., Losa, R., Zweifel, B., & Wallace, R. J. (2012) · Microbiology · doi:10.1099/mic.0.061127-0 · Cited by 92 · see citing works
Krogsgaard, L. R., Andersen, L. O., Johannesen, T. B., Engsbro, A. L., Stensvold, C. R., Nielsen, H. V., & Bytzer, P. M. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0027-2 · Cited by 88 · see citing works
The Role of Bacteria in the Pathogenesis of Ulcerative Colitis
Sasaki, M., & Klapproth, J. A. (2012) · Journal of Signal Transduction · doi:10.1155/2012/704953 · Cited by 87 · see citing works
Napolitano, M., Fasulo, E., Ungaro, F., Massimino, L., Sinagra, E., Danese, S., & Mandarino, F. V. (2023) · Microorganisms · doi:10.3390/microorganisms11102369 · Cited by 93 · see citing works
Quigley, E. M. M. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15621230 · Cited by 86 · see citing works
Space Environmental Factor Impacts upon Murine Colon Microbiota and Mucosal Homeostasis
Ritchie, L. E., Taddeo, S. S., Weeks, B. R., Lima, F., Bloomfield, S. A., Azcárate-Peril, M. A., Zwart, S. R., Smith, S. M., & Turner, N. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125792 · Cited by 80 · see citing works
Ritchie, L. E., Sturino, J. M., Carroll, R. J., Rooney, L. W., Azcárate-Peril, M. A., & Turner, N. D. (2015) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiv008 · Cited by 78 · see citing works
He, Q., Wang, L., Wang, F., Wang, C., Tang, C. X., Li, Q., Li, J., & Zhao, Q. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-289 · Cited by 77 · see citing works
Comparison of the Distal Gut Microbiota from People and Animals in Africa
Ellis, R. J., Bruce, K. D., Jenkins, C., Stothard, J. R., Ajarova, L., Mugisha, L., & Viney, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054783 · Cited by 76 · see citing works
Sun, Y., Cui, X., Duan, M., Ai, C., Song, S., & Chen, X. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.05.036 · Cited by 73 · see citing works
Sung, J., Kim, N., Kim, J., Jo, H. J., Park, J. H., Nam, R. H., Seok, Y., Kim, Y.-R., Lee, D. H., & Jung, H. C. (2016) · Journal of Cancer Prevention · doi:10.15430/jcp.2016.21.1.60 · Cited by 73 · see citing works
Sun, S., Korheina, D. K. A., Fu, H., & Ge, X. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137478 · Cited by 72 · see citing works
The Role of the Human Microbiome in the Pathogenesis of Pain
Ustianowska, K., Ustianowski, Ł., Machaj, F., Gorący, A., Rosik, J., Szostak, B., Szostak, J., & Pawlik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113267 · Cited by 75 · see citing works
Gaifem, J., Mendes‐Frias, A., Wolter, M., Steimle, A., Garzón, M. J., Úbeda, C., Nobre, C., González, A., Pinho, S. S., Cunha, C., et al. (2024) · mBio · doi:10.1128/mbio.00078-24 · Cited by 72 · see citing works
Banerjee, A., & Shelver, W. L. (2021) · Journal of Food Protection · doi:10.4315/jfp-21-117 · Cited by 68 · see citing works
Kortman, G. A. M., Mulder, M. L. M., Richters, T. J. W., Shanmugam, N. K. N., Trebicka, E., Boekhorst, J., Timmerman, H. M., Roelofs, R., Wiegerinck, E. T., Laarakkers, C. M., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545642 · Cited by 65 · see citing works
Emerging Treatment Options in Mild to Moderate Ulcerative Colitis.
Lichtenstein, G. R., Hanauer, S. B., & Sandborn, W. J. (2015) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
Khalil, N. A., Walton, G., Gibson, G. R., Tuohy, K. M., & Andrews, S. C. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.825700 · Cited by 66 · see citing works
Liu, J., Lv, M., Sun, A., Ding, J., Wang, Y., Chang, X., & Chen, L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133810 · Cited by 66 · see citing works
Probiotics: The Scientific Evidence in the Context of Inflammatory Bowel Disease
Celiberto, L. S., Bedani, R., Rossi, E. A., & Cavallini, D. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.941457 · Cited by 64 · see citing works
Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
Baritaki, S., de Bree, E., Chatzaki, Ε., & Pothoulakis, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101669 · Cited by 67 · see citing works
A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer
Scott, N. E., Whittle, E., Jeraldo, P., & Chia, N. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100797 · Cited by 62 · see citing works
Ding, R., Ma, Y., Li, T., Sun, M., Sun, Z., & Duan, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163144 · Cited by 64 · see citing works
Simulated microgravity disrupts intestinal homeostasis and increases colitis susceptibility
Li, P., Shi, J.-X., Zhang, P., Wang, K., Li, J., Liu, H., Zhou, Y., Xu, X., Hao, J., Sun, X., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271700 · Cited by 61 · see citing works
Hudcovic, T., Kolinska, J., Klepetar, J., Stepankova, R., Řezanka, T., Šrůtková, D., Schwarzer, M., Erban, V., Du, Z., Wells, J. M., et al. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04498.x · Cited by 60 · see citing works
The Role of the Gastrointestinal Microbiota in Visceral Pain
Rea, K., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_115 · Cited by 62 · see citing works
Understanding the Gut Microbiota in Inflammatory and Functional Gastrointestinal Diseases
Sundin, J., Öhman, L., & Simrén, M. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000470 · Cited by 60 · see citing works
The colonic mucus protection depends on the microbiota
Rodríguez-Piñeiro, A. M., & Johansson, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1086057 · Cited by 56 · see citing works
Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier
Chen, S.-J., Liu, X., Liu, J.-P., Xi-yan, Y., & Lu, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9468 · Cited by 58 · see citing works
Storr, M., Vogel, H. J., & Schicho, R. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328361f488 · Cited by 57 · see citing works
Walujkar, S. A., Kumbhare, S. V., Marathe, N. P., Patangia, D. V., Lawate, P. S., Bharadwaj, R. S., & Shouche, Y. S. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2449-0 · Cited by 56 · see citing works
Kim, J., Kim, N., Jo, H. J., Park, J. H., Nam, R. H., Seok, Y., Kim, Y.-R., Kim, J. S., Kim, J. M., Kim, J. M., et al. (2015) · Helicobacter · doi:10.1111/hel.12214 · Cited by 55 · see citing works
Du, Z., Hudcovic, T., Mrázek, J., Kozáková, H., Šrůtková, D., Schwarzer, M., Tlaskalová‐Hogenová, H., Kostovčík, M., & Kverka, M. (2015) · Gut Pathogens · doi:10.1186/s13099-015-0080-2 · Cited by 54 · see citing works
Carvalho, R. D. D. O., Vaz, A. B. M., Pereira, F. L., Dorella, F. A., Aguiar, E. R. G. R., Chatel, J., Bermúdez‐Humarán, L. G., Langella, P., Fernandes, G. D. R., Figueiredo, H. C. P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33469-w · Cited by 52 · see citing works
The microbiome and childhood diseases: Focus on brain‐gut axis
O’Mahony, S. M., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21118 · Cited by 50 · see citing works
Oral Delivery of Nisin in Resistant Starch Based Matrices Alters the Gut Microbiota in Mice
Gough, R., Cabrera‐Rubio, R., O’Connor, P. M., Crispie, F., Brodkorb, A., Miao, S., Hill, C., Ross, R. P., Cotter, P. D., Nilaweera, K. N., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01186 · Cited by 50 · see citing works
Zeng, W., He, D., Xing, Y., Liu, J., Su, N., Zhang, C., Wang, Y., & Xing, X. (2021) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.02.016 · Cited by 53 · see citing works
Mizuno, S., Ono, K., Mikami, Y., Naganuma, M., Fukuda, T., Minami, K., Masaoka, T., Terada, S., Yoshida, T., Saigusa, K., et al. (2020) · Intestinal Research · doi:10.5217/ir.2019.00084 · Cited by 50 · see citing works
Fernández, J., de la Fuente, V. G., García, M. T. F., Sánchez, J. G., Redondo, B. I., Villar, C. J., & Lombó, F. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01205-x · Cited by 49 · see citing works
Impact of Microplastics on the Ocular Surface
Wu, D., Lim, B. X. H., Seah, I. Y. J., Xie, S., Jaeger, J. E., Symons, R. K., Heffernan, A. L., Curren, E., Leong, S. C. Y., Riau, A. K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043928 · Cited by 44 · see citing works
Song, X., Wang, W., Ding, S., Wang, Y., Ye, L., Chen, X., & Ma, H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.044 · Cited by 44 · see citing works
Bassett, S. A., Young, W., Barnett, M. P. G., Cookson, A. L., McNabb, W. C., & Roy, N. C. (2015) · Nutrients · doi:10.3390/nu7031798 · Cited by 43 · see citing works
Mast Cells in Irritable Bowel Syndrome: A Systematic Review
Krammer, L., Sowa, A. S., & Lorentz, A. (2019) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-229 · Cited by 43 · see citing works
He, Q., Wang, L., Wang, F., & Li, Q. (2014) · Zebrafish · doi:10.1089/zeb.2013.0917 · Cited by 42 · see citing works
Yoon, H., Kim, H., Lee, S. H., Kim, S. J., Chang, Y., Ryu, S., Shin, H., Kim, H.-L., & Lee, J. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-34398-4 · Cited by 41 · see citing works
Intestinal bacteria associated with irritable bowel syndrome and chronic fatigue
El‐Salhy, M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14621 · Cited by 40 · see citing works
Chen, L., He, Z., Iuga, A. C., Martins-Filho, S. N., Faith, J. J., Clemente, J. C., Deshpande, M., Jayaprakash, A. D., Colombel, J., Lafaille, J. J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.034 · Cited by 40 · see citing works
Phenotypic variation in Blastocystis sp. ST3
Ragavan, N. D., Govind, S. K., Chye, T. T., & Mahadeva, S. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-404 · Cited by 40 · see citing works
Prevention of antibiotic‐associated metabolic syndrome in mice by intestinal alkaline phosphatase
Economopoulos, K. P., Ward, N. L., Phillips, C. D., Teshager, A., Patel, P. Y., Mohamed, M. M., Hakimian, S., Cox, S. B., Ahmed, R., Moaven, O., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12645 · Cited by 39 · see citing works
Strain, C., Collins, K. C., Naughton, V. R., McSorley, E. M., Stanton, C., Smyth, T. J., Soler‐Vila, A., Rea, M. C., Ross, R. P., Cherry, P., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01909-6 · Cited by 39 · see citing works
- Authors
- Noor, S. O., Ridgway, K., Scovell, L., Kemsley, E. K., Lund, E. K., Jamieson, C., Johnson, I. T., & Narbad, A.
- Affiliations
- Norwich Research Park (GB)
- Norfolk and Norwich University Hospital (GB)
- Corresponding author
- Narbad, Arjan
- Venue
- BMC Gastroenterology
- Published
- 2010-11-12
- Volume
- 10
- Issue
- 1
- Pages
- 134-134
- ISSN
- 1471-230X (ISSN-L)
- PMC
- PMC3002299
- OpenAlex
- W2086580205
- Cited by
- 227
- References
- 56
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 12 · 2020: 17 · 2019: 22 · 2018: 16 · 2017: 6 · 2016: 15 · 2015: 27 · 2014: 23 · 2013: 15 · 2012: 15
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Gastroenterology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- ulcerative colitis, irritable bowel syndrome, gut microbiota, Bacteroides, Bacteroides vulgatus, Bacteroides ovatus, Bacteroides uniformis, Parabacteroides, bacterial diversity, 16S rRNA gene sequencing, PCR-DGGE, inflammatory bowel disease, dysbiosis
- MeSH terms
- Adult, Bacteroides, Colitis, Ulcerative, Feces, Female, Humans, Male, Middle Aged, Multivariate Analysis, Case-Control Studies, Polymerase Chain Reaction, Gastrointestinal Tract, Irritable Bowel Syndrome, Young Adult, Denaturing Gradient Gel Electrophoresis, Molecular Typing
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