Aspergillus biofilms: clinical and industrial significance
Abstract
The biofilm phenotype is an increasingly important concept in mycological research. Recently, there has been a developing interest in whether Aspergillus species are truly able to form biofilms or not. Industrial mycologists have long been aware of biofilms and their benefit in fermentation processes, whereas clinically their role is uncertain. This review provides an update on the impact that Aspergillus biofilms have medically and industrially, and will discuss biofilm development, and our current understanding of its molecular basis. The role of exopolymeric substance and how this substance relates to antimicrobial recalcitrance will also be discussed.
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Aspergillus is a fungal pathogen of great medical importance that can form biofilms both in vitro and in vivo.
“Aspergillus is a fungal pathogen of great medical importance that can form biofilms both in vitro and in vivo (125, 159).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [159]
Aspergillomas may form as Aspergillus fumigatus continues to proliferate in the respiratory tract, and these structures share many architectural characteristics with biofilms formed by other fungal species.
“Aspergillomas, or dense hyphal balls, may also form as A. fumigatus continues to proliferate in the respiratory tract; these structures share many architectural characteristics with biofilms formed by other fungal species (159).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [159]
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- Authors
- Ramage, G., Rajendran, R., Gutierrez-Correa, M., Jones, B., & Williams, C.
- Affiliations
- University of Glasgow (GB)
- Laboratory of Mycology and Biotechnology; Universidad Nacional Agraria La Molina; Lima; Peru
- Glasgow Royal Infirmary (GB)
- Royal Hospital for Children (GB)
- Corresponding author
- Ramage, Gordon
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-08
- Volume
- 324
- Issue
- 2
- Pages
- 89-97
- ISSN
- 0378-1097 (ISSN-L)
- OpenAlex
- W1994606405
- Cited by
- 136
- References
- 95
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 3 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 7
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Aspergillus, biofilm, exopolysaccharides, antimicrobial resistance, medical mycology, industrial fermentation, biofilm formation
- MeSH terms
- Animals, Anti-Bacterial Agents, Aspergillosis, Aspergillus, Humans, Industrial Microbiology, Biofilms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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