Cited by 80Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

Candida Species: New Insights into Biofilm Formation

Cuéllar-Cruz, Mayra, López-Romero, Everardo, Villagómez-Castro, Julio C, Ruiz-Baca, Estela·2012·Future Microbiology

Abstract

Biofilms of Candida albicans, Candida parapsilosis, Candida glabrata and Candida tropicalis are associated with high indices of hospital morbidity and mortality. Major factors involved in the formation and growth of Candida biofilms are the chemical composition of the medical implant and the cell wall adhesins responsible for mediating Candida-Candida, Candida-human host cell and Candida-medical device adhesion. Strategies for elucidating the mechanisms that regulate the formation of Candida biofilms combine tools from biology, chemistry, nanoscience, material science and physics. This review proposes the use of new technologies, such as synchrotron radiation, to study the mechanisms of biofilm formation. In the future, this information is expected to facilitate the design of new materials and antifungal compounds that can eradicate nosocomial Candida infections due to biofilm formation on medical implants. This will reduce dissemination of candidiasis and hopefully improve the quality of life of patients.

Integrity signals

Registry

Crossref · 10.2217/fmb.12.48

Cites

177 of 177 references verified0 citation errors · 0 not checkable

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  • A majority of manifestations of infections caused by Candida spp are associated with a biofilm etiology.

    “A majority of manifestations of infections caused by Candida spp are associated with a biofilm etiology [5,8,9].”
  • Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which complicates therapy of these infections.

    “Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections.”
  • Among pathogenic fungi, Candida spp. are the most frequently associated with biofilm formation.

    “among pathogenic fungi, Candida spp. are the most frequently associated with biofilm formation [5,8,9].”

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Authors
Cuéllar-Cruz, M., López-Romero, E., Villagómez-Castro, J. C., & Ruiz-Baca, E.
Affiliations
  • Unidad de Biotecnología Médica & Farmacéutica, Centro de Investigación & Asistencia en Tecnología & Diseño del Estado de Jalisco, A.C., Guadalajara, Jalisco, México.
  • Universidad de Guanajuato (MX)
  • Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Durango, México
Venue
Future Microbiology
Published
2012-06
Volume
7
Issue
6
Pages
755-771
ISSN
  • 1746-0913 (ISSN-L)
  • 1746-0921
OpenAlex
W2165010118
Cited by
80
References
176
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 14 · 2014: 7 · 2013: 9 · 2012: 1
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Locations
  • Future Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Guanajuato (UGTO-000165/11, UGTO-00023/11)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida biofilms, biofilm formation, Candida albicans, Candida parapsilosis, Candida glabrata, Candida tropicalis, synchrotron radiation, antifungal materials, nosocomial candidiasis, biomedical implants
MeSH terms
Candida, Candidiasis, Cross Infection, Equipment and Supplies, Humans, Virulence, Biofilms

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