Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder: Aberrant neural incentive processes in OCD

Jung, W. H.; Kang, D.-H.; Han, J. Y.; Jang, J. H.; Gu, B.-M.; Choi, J.-S.; Jung, M. H.; Choi, C.-H.; Kwon, J. S.

doi:10.1111/j.1600-0447.2010.01659.x

Cited by 68Obsessive-Compulsive Spectrum DisordersNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder: Aberrant neural incentive processes in OCD

Jung, W. H., Kang, D.-H., Han, J. Y., Jang, J. H., Gu, B.-M., Choi, J.-S., Jung, M. H., Choi, C.-H. +1 more·2011·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2010.01659.x

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Abstract

OBJECTIVE: Obsessive-compulsive disorder (OCD) is characterized by the dysfunction of control and reward mechanisms. However, only few neuroimaging studies of OCD have examined the reward processing. We examined the neural responses during incentive processing in OCD. METHOD: Twenty unmedicated patients with OCD and 20 age-, sex-, and IQ-matched healthy controls underwent functional magnetic resonance imaging while performing a modified monetary incentive delay task. RESULTS: Compared with controls, patients with OCD showed increased ventral striatal activation in the no-loss minus loss outcome contrast and a significant positive correlation between the ventral striatal activation and compulsion symptom severity. In addition, patients with OCD showed increased activations in the frontostriatal regions in the gain minus no-gain outcomes contrast. During loss anticipation, patients with OCD showed less activations in the lateral prefrontal and inferior parietal cortices. However, during gain anticipation, patients with OCD and healthy controls did not differ in the ventral striatal activation. CONCLUSION: These findings provide neural evidence for altered incentive processing in unmedicated patients with OCD, suggesting an elevated sensitivity to negatively affect stimuli as well as dysfunction of the ventral striatum.

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Jung et al. found increased frontostriatal activation during monetary-reward outcome, decreased lateral prefrontal and inferior parietal cortex activation during loss anticipation, but no group differences during monetary-reward anticipation in OCD.
“Using a monetary incentive-delay task, Jung et al. [515] found increased frontostriatal activation during monetary-reward outcome, and decreased lateral prefrontal and inferior parietal cortex activation during loss anticipation, but no group differences during monetary-reward anticipation.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [515]

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Additional file 1 of Altered neural anticipation of reward and loss but not receipt in adolescents with obsessive-compulsive disorder
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Authors: Jung, W. H., Kang, D.-H., Han, J. Y., Jang, J. H., Gu, B.-M., Choi, J.-S., Jung, M. H., Choi, C.-H., & Kwon, J. S.
Affiliations: Seoul National University (KR)
National Medical Center (KR)
Corresponding author: Kwon, J. S.
ORCID: Jung, W. H.
Kang, D.-H.
Jang, J. H.
Gu, B.-M.
Choi, J.-S.
Jung, M. H.
Choi, C.-H.
Kwon, J. S.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2010-12-22
Volume: 123
Issue: 5
Pages: 376-386
ISSN: 0001-690X (ISSN-L)
DOI: 10.1111/j.1600-0447.2010.01659.x
OpenAlex: W2142897117
Cited by: 68
References: 51
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 5
FWCI: 3.87
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1714 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: obsessive-compulsive disorder, ventral striatum, incentive processing, reward processing, monetary incentive delay task, loss anticipation, unmedicated patients
MeSH terms: Adult, Attention, Basal Ganglia, Brain Mapping, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Motivation, Obsessive-Compulsive Disorder, Reward, Prefrontal Cortex, Anticipation, Psychological

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Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder: Aberrant neural incentive processes in OCD

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