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Randomized trial of Internet-based relapse prevention for partially remitted depression: Preventing relapse in MDD via the Internet
Abstract
OBJECTIVE: To investigate whether Internet-based cognitive behaviour therapy (CBT) can prevent relapse in persons with partially remitted major depression after previous treatment. METHOD: Seventy-one women and 13 men (N = 84) with partially remitted major depression after treatment were randomly assigned to either 10 weeks of Internet-based CBT or to a control group. Self-help material was used in combination with e-mail contact with a personal therapist. Monthly self-ratings of depressive symptoms were made, and diagnostic interviews were conducted before and after the treatment period, as well as 6 months later. RESULTS: Significantly fewer participants in the CBT group experienced relapse (4/38 or 10.5%) compared with those in the control group (14/37 or 37.8%). The difference in relapse rates between groups occurred early in the study period and was still apparent after 6 months. A trend towards a larger reduction in depressive symptoms was observed at post-treatment in the participants who received CBT compared with controls. Reduction in depressive symptoms reduced the risk of relapse. A trend towards a higher remission rate was found in the CBT group at the 6 month follow-up. CONCLUSION: Internet-based CBT seems promising in preventing relapse in persons with partially remitted major depression after previous treatment.
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“Several studies had multiple follow-up points, varying from 26 to 66 months [65–72].”
From Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as [67]
In the citing paper
“Previous studies have combined computerized manuals with face-to-face treatment [20,21], used technological adjuncts in therapy [22], or used the Internet after treatment completion to help prevent relapse [23,24].”
From Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study (2013) · cites this paper as [24]
In the citing paper
“Significantly, fewer participants receiving ICBT experienced relapse compared with those in the control group (10.5 compared with 37.8%), which is in line with previous face-to-face studies [30].”
From Internet-based psychological treatments for depression (2012) · cites this paper as [29]
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Metadata
- Authors
- Holländare, F., Johnsson, S., Randestad, M., Tillfors, M., Carlbring, P., Andersson, G., & Engström, I.
- Affiliations
- Örebro University (SE)
- Umeå University (SE)
- Linköping University (SE)
- Corresponding author
- Holländare, F.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2011-03-14
- Volume
- 124
- Issue
- 4
- Pages
- 285-294
- ISSN
- 0001-690X (ISSN-L)
- OpenAlex
- W1561161729
- Cited by
- 111
- References
- 53
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 18 · 2016: 8 · 2015: 16 · 2014: 12 · 2013: 18 · 2012: 8
- FWCI
- 17.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- relapse prevention, major depressive disorder, internet-based cognitive behavioral therapy, e-therapy, self-help, depressive symptoms, remission, women
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Patient Compliance, Psychiatric Status Rating Scales, Cognitive Behavioral Therapy, Treatment Outcome, Internet, Secondary Prevention
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