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Cited by 117Schizophrenia research and treatmentChild Abuse and TraumaResilience and Mental Health

Adversity and psychosis: a 10‐year prospective study investigating synergism between early and recent adversity in psychosis

Lataster, J., Myin‐Germeys, I., Lieb, R., Wittchen, H.‐U., van Os, J.·2012·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.2011.01805.x
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Abstract

OBJECTIVE: Recent studies have suggested that early adverse events, such as childhood trauma, may promote enduring liability for psychosis whereas more recent adverse events may act as precipitants. Examination of these environmental dynamics, however, requires prospective studies in large samples. This study examines whether the association between recent adverse events and psychosis is moderated by exposure to early adversity. METHOD: A random regional representative population sample of 3021 adolescents and young adults in Munich, Germany, was assessed three times over a period of up to 10 years, collecting information on sociodemographic factors, environmental exposures, and measures of psychopathology and associated clinical relevance. Evidence of statistical non-additivity between early adversity (two levels) and more recent adversity (four levels) was assessed in models of psychotic symptoms. Analyses were a priori corrected for age, gender, cannabis use, and urbanicity. RESULTS: Early and recent adversity were associated with each other (RR = 1.32, 95% CI 1.06-1.66; P = 0.014) and displayed statistical non-additivity at the highest level of exposure to recent adversity (χ(2) = 4.59; P = 0.032). CONCLUSION: The findings suggest that early adversity may impact on later expression of psychosis either by increasing exposure to later adversity and/or by rendering individuals more sensitive to later adversity if it is severe.

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Crossref · 10.1111/j.1600-0447.2011.01805.x

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  • The association between recent adversity and psychotic symptoms was much stronger in individuals exposed to early adversity compared with those who were not.

    “The authors concluded that the association between recent adversity and psychotic symptoms was much stronger in individuals exposed to early adversity compared with those who were not.”

    From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [40]

  • Lataster et al., in a prospective study of over 3000 adolescents, found that both childhood and recent adversity were associated with increased psychotic symptoms and psychotic impairments (defined as either social dysfunction or seeking help for symptoms of psychosis).

    “Lataster et al. , in a prospective study of over 3000 adolescents, found that both childhood and recent adversity were associated with increased psychotic symptoms and psychotic impairments (defined as either social dysfunction or seeking help for symptoms of psychosis) [40] .”

    From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [40]

  • An interaction effect was observed between early adversity, recent adversity and psychosis, with an adjusted odds ratio of 4.1 for symptoms of psychosis and 6.4 for psychotic impairments.

    “Furthermore, an interaction effect was observed between early adversity, recent adversity and psychosis, with an adjusted odds ratio of 4.1 for symptoms of psychosis and 6.4 for psychotic impairments.”

    From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [40]

  • Stressful and adverse experiences are associated with an increased risk of developing a psychotic disorder, although this relationship may be partially mediated by familial risk factors.

    “Stressful and adverse experiences are associated with an increased risk of developing a psychotic disorder(108), although this relationship may be partially mediated by familial risk factors (109).”

    From Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis (2020) · cites this paper as [108]

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Authors
Lataster, J., Myin‐Germeys, I., Lieb, R., Wittchen, H. ‐., & van Os, J.
Affiliations
  • Maastricht University Medical Centre (NL)
  • University of Basel (CH)
Corresponding author
Myin‐Germeys, I.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2011-11-30
Volume
125
Issue
5
Pages
388-399
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.2011.01805.x
OpenAlex
W1791415059
Cited by
117
References
90
Citations by year
2026: 4 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 7 · 2020: 14 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 4 · 2014: 15 · 2013: 9 · 2012: 9
FWCI
7.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Lirias (KU Leuven) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • DSpace (Open University in the Netherlands) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Keywords
psychosis, childhood adversity, childhood trauma, environmental risk factors, synergistic effect, moderation, psychotic symptoms, adolescents and young adults, psychopathology, cannabis use
MeSH terms
Adolescent, Child Abuse, Female, Germany, Humans, Life Change Events, Longitudinal Studies, Male, Marijuana Smoking, Prospective Studies, Psychotic Disorders, Risk Factors, Social Environment, Stress, Psychological, Young Adult

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