Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity
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Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological mechanisms mediating this relationship remain unclear. In parallel, alterations in corticostriatal connectivity and abnormalities in the processing of salience, are seen in psychotic disorders. Aberrant functioning of these mechanisms secondary to chronic stress exposure, could help explain how common environmental exposures are associated with a diverse range of symptoms. In the current study, we recruited two groups of adults, one with a high degree of exposure to chronic psychosocial stressors (the exposed group, n = 20), and one with minimal exposure (the unexposed group, n = 22). All participants underwent a resting state MRI scan, completed the Aberrant Salience Inventory, and performed a behavioural task - the Salience Attribution Test (SAT). The exposed group showed reduced explicit adaptive salience scores (cohen's d = 0.69, p = 0.03) and increased aberrant salience inventory scores (d = 0.65, p = 0.04). The exposed group also showed increased corticostriatal connectivity between the ventral striatum and brain regions previously implicated in salience processing. Corticostriatal connectivity in these regions negatively correlated with SAT explicit adaptive salience (r = -0.48, p = 0.001), and positively correlated with aberrant salience inventory scores (r = 0.42, p = 0.006). Furthermore, in a mediation analysis there was tentative evidence that differences in striato-cortical connectivity mediated the group differences in salience scores.
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This case illustrates the link between ELA and FA which is likely mediated by biological mechanisms including altered DA signaling.
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- Authors
- McCutcheon, R. A., Bloomfield, M. A. P., Dahoun, T., Mehta, M., & Howes, O. D.
- Affiliations
- King's College London (GB)
- University College Hospital (GB)
- Hammersmith Hospital (GB)
- Corresponding author
- Howes, Oliver D.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 213
- Pages
- 56-64
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC6817361
- OpenAlex
- W2904401488
- Cited by
- 35
- References
- 81
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 3
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Schizophrenia Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (200102/Z/15/Z, 094849/Z/10/Z)
- National Institute for Health Research
- Medical Research Council (MC-A656-5QD30)
- South London and Maudsley NHS Foundation Trust
- King’s College London
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- chronic psychosocial stress, salience processing
- MeSH terms
- Adult, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Reward, Stress, Psychological, Visual Perception, Young Adult, Connectome, Ventral Striatum
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